San Diego Padres vs Colorado Rockies Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Colorado Rockies

Date: Wednesday, April 22, 2026

Location: Coors Field in Denver, CO

TV: Rockies.TV

Odds/Point Spread: San Diego (-144) Colorado (+120)

The San Diego Padres (15-7) are traveling to Coors Field on Wednesday where they will attempt to defeat the Colorado Rockies (9-14). The line on this contest has San Diego at -144 while Colorado opens at +120. The over/under has been set at 8.5. The pitchers taking the mound will be Walker Buehler and Tomoyuki Sugano.

As a unit, the San Diego Padres are knocking in 4.4 runs per game, which has them at 15th in the league. They have accounted for 96 runs scored and hold an on-base percentage of .310. The Padres have hit 44 doubles as a squad and have smacked 17 balls out of the park. They have accrued 91 RBI's and 168 hits so far this year, and their team batting average is .232. San Diego has a slugging percentage of .369 and have struck out 171 times, while drawing a walk on 78 occasions.

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The Padres hold a team ERA of 3.36 on the campaign (5th in the league), and the staff has struck out 212 batters. Padres pitchers have allowed 13 home runs in addition to 79 runs in total (3rd in MLB). Their pitching staff has walked 76 opposing batters and their FIP is 3.19 as a team for the year. San Diego has surrendered 168 base hits (7.6 per 9 innings) as well as 74 earned runs. Their K/BB ratio is 2.79 and their pitching staff holds a WHIP of 1.23.

The Padres have dispatched 77 relievers to the hill on the year. The relief pitchers have inherited 37 runners on the year and 43.2% of them crossing the plate. The bullpen have a total of 18 holds so far this season (7th in baseball). Padres bullpen pitchers have entered the game with runners on 21 times in addition to having 25 appearances in high leverage situations. They have compiled 9 saves for the year and have blown 5 of their 14 save chances. The Padres relievers have earned a save percentage of 64.3% and stepped onto the hill in 34 save situations.

The Padres have converted 69.1% of baseballs in play into outs out of their 1,782 innings on the field, which has them sitting 22nd in professional baseball. The San Diego Padres have earned a total of 594 putouts so far this season, in addition to 184 assists and 6 errors. Their fielding percentage is at .992 which ranks 3rd in professional baseball, and have accumulated 19 double plays.

Buehler has taken the ball for 856 innings and has totaled 864 strikeouts during his MLB career. His ERA is 3.54 (337 ER's allowed) and he has a career WHIP of 1.157. He has given up 734 base knocks (7.7 hits per 9 innings) and has 257 free passes. Buehler (58-30 win-loss mark in his career) sits with a FIP of 3.49 and he has gone up against 3,540 batters during his time in the majors.

Colorado has recorded 23 long balls on the campaign and 89 runs batted in. They have tallied 40 doubles, while getting a free base 66 times and scoring 92 runs. The Colorado Rockies have compiled a team on-base percentage of .310 as well as a batting average of .244 so far this year. The Rockies have a slugging percentage of .390 and they are recording 4.00 runs per game (22nd in the league). They have struck out on 221 occasions (4th in baseball) and have notched a total of 188 base hits.

The Rockies have a WHIP of 1.425 in addition to having a FIP of 4.84 as a staff so far this year. They currently have a K/BB ratio of 7.60 (170 strikeouts against 77 free passes). They are sitting at 27th in the league as a pitching staff in total hits allowed with 211. They have conceded 32 home runs and they allow 4.94 runs per 9 innings (22nd in the league). The Colorado pitching staff have allowed 111 runs over the course of the season while holding a team ERA of 4.41 (99 earned runs relinquished).

With 17 save situations, the Rockies have earned 8 holds and also 2 blown saves. Colorado has called on bullpen pitchers to enter the game in 9 save chances and they have tallied 7 saves. Colorado relievers hold an inherited score percentage of 15.8% out of their 38 inherited runners. Their relief pitchers have stepped onto the hill 27 times in high leverage situations and also on 24 occasions with runners on. They are currently ranked 5th in baseball with a save rate of 77.8%, and they have dispatched 69 relievers to the hill this year.

In their 1,821 innings on the diamond, the Rockies are sitting with a defensive efficiency of 68.8% (23rd in MLB). The Colorado Rockies have gotten 21 double plays and own a fielding percentage of .985 (16th in MLB). The Rockies have accrued 199 assists, 12 errors and have accumulated 607 putouts this year.

So far in his career, Sugano has surrendered 192 hits and he has 121 strikeouts in 177 innings. Sugano (11-11 mark in his career) has a 4.57 ERA while allowing 9.8 hits per 9 innings. He has allowed 90 earned runs while earning a WHIP of 1.315 and having a FIP of 4.5. He has a strikeout to walk ratio of 2.95 and he has faced 761 opposing batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take San Diego (-144)

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