San Diego Padres vs Los Angeles Dodgers Prediction, 9/22/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Los Angeles Dodgers

Date: Tuesday, September 22, 2026

Location: Dodger Stadium in Los Angeles, CA

TV: Spectrum SportsNet LA

Odds/Point Spread: San Diego (+126) Los Angeles (-152)

Dodger Stadium is the location where the Los Angeles Dodgers (96-60) will take on the San Diego Padres (87-69) on Tuesday. The moneyline on this contest has the Padres at +126 and the Dodgers are priced at -152. The over/under is 8. The pitchers taking the mound are Michael King and Roki Sasaki.

The Padres have tallied 228 doubles as a squad and have hit 179 balls out of the stadium. San Diego is slugging .400 and have struck out 1,257 times, while taking a walk on 536 occasions. As a unit, the San Diego Padres are notching 4.4 runs per outing, which ranks them 18th in the league. They have compiled 665 runs batted in and 1,261 hits so far this season, while their batting average is at .244. They have accumulated 690 runs scored and have an OBP of .319.

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The Padres have a team ERA of 3.94 on the campaign (10th in the league), and the staff has struck out 1,267 hitters. Padres pitchers have allowed 174 home runs in addition to 649 runs in total (9th in MLB). Their pitching staff has walked 528 opposing players and their FIP is 4.18 as a unit on the season. San Diego has allowed 1,252 base knocks (8.1 per 9 innings) as well as 605 earned runs. They have earned a strikeout to walk ratio of 2.40 and their pitching staff has a collective WHIP of 1.29.

The Padres relief pitchers have a save rate of 71.2% and have stepped onto the mound in 172 save situations. They have earned 47 saves for the season and have missed out on 19 of 66 save opportunities. The relief pitchers have inherited 243 base runners on the season and 31.3% of them ended up scoring. Padres relief pitchers have stepped onto the hill with runners on base 150 times in addition to having 184 appearances in high leverage situations. The Padres have dispatched 529 relief pitchers to the hill so far this season. The relievers have a total of 102 holds on the year (5th in the league).

The Padres have turned 70.7% of balls hit into play into outs in their 12,450 innings, which has them sitting 10th in pro baseball. The San Diego Padres are sitting with 4,150 putouts for the season, as well as 1,381 assists and 63 errors. Their fielding percentage is currently at .989 which puts them in 3rd in MLB, and have 126 double plays.

King (43-38 career mark) has a FIP of 3.14 and he has gone up against 2,805 hitters in the major leagues. He has given up 560 base hits (7.5 hits per nine innings) and has had 240 free passes. His earned run average is 3.19 (239 ER's allowed) and his WHIP is 1.185. King has taken the hill for 675 frames and is sitting with 713 punch outs in his pro baseball career.

The Los Angeles Dodgers hold a team on-base percentage of .339 and a team batting average of .257 for the year. They have been rung up on 1,215 occasions (27th in baseball) and have recorded 1,349 hits. Los Angeles has recorded 197 HRs for the year to go along with 736 runs batted in. The Dodgers hold a slugging % of .426 and they score 5.00 runs per game (4th in baseball). They have 258 doubles, while getting a free base 607 times as well as scoring 780 runs.

The Los Angeles pitching staff have given up 587 runs for the season while having an ERA of 3.62 (555 earned runs relinquished). They have given up 171 homers and they surrender 3.83 runs per 9 innings (2nd in baseball). The Dodgers hold a team WHIP of 1.155 with a FIP of 3.77 as a pitching staff for the year. Their strikeout to walk ratio sits at 9.50 (1,450 strikeouts vs 471 bases on balls). They are sitting at 1st in baseball as a staff in total hits given up with 1,123.

They are ranked 13th in the league with a save rate of 66.7%, and they have sent 512 relievers to the mound over the course of the season. Their relief pitchers have stepped onto the hill 166 times in high leverage situations and also on 110 occasions with runners on. Sitting with 166 save situations, the Dodgers have earned 99 holds and also 22 blown saves. Los Angeles has had relief pitchers enter the contest in 66 save opportunities and they have converted 44 saves. Los Angeles bullpen pitchers hold an inherited score percentage of 35.0% of 177 inherited runners.

The Los Angeles Dodgers have turned 87 double plays and own a fielding percentage of .989 (4th in professional baseball). The Dodgers have racked up 1,243 assists, 62 errors and have earned 4,142 putouts this season. In 12,426 innings on the field, the Dodgers have earned a efficiency on defense of 72.1% (2nd in professional baseball).

During his career, Sasaki has given up 141 hits while earning 145 strikeouts in 155 innings. Sasaki (6-6 career mark) is the owner of a 4.58 ERA while allowing 8.2 hits per 9 innings. He has given up a total of 79 ER's while holding a WHIP of 1.360 and being the owner of a FIP of 4.5. His K/BB ratio is 2.07 and he has gone up against 672 hitters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (+126)

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