San Diego Padres vs Los Angeles Dodgers Prediction, 9/23/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Los Angeles Dodgers

Date: Wednesday, September 23, 2026

Location: Dodger Stadium in Los Angeles, CA

TV: Spectrum SportsNet LA

Odds/Point Spread: San Diego (+150) Los Angeles (-182)

The Los Angeles Dodgers (96-60) will compete against the San Diego Padres (87-69) at Dodger Stadium on Wednesday. The odds on this game have San Diego at +150 and Los Angeles is at -182. The over/under comes in at 8. The starting pitchers are Robbie Ray and Yoshinobu Yamamoto.

The Padres have accounted for 228 doubles as a squad and have hit 179 balls out of the park. San Diego is slugging .400 and have struck out 1,257 times, while drawing a walk on 536 occasions. As a team, the San Diego Padres are recording 4.4 runs per contest, which is 18th in MLB. They have recorded 665 runs batted in as well as 1,261 hits on the year, and their team batting average sits at .244. They have earned 690 runs scored while holding a team on-base percentage of .319.

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They have accumulated a K/BB ratio of 2.40 and the pitching staff has a collective WHIP of 1.29. Padres pitchers have yielded 174 long balls and also 649 runs in total (9th in the league). San Diego has conceded 1,252 hits (8.1 per 9 innings) and 605 earned runs. The Padres have an ERA of 3.94 so far this season (10th in MLB), and their staff has rung up 1,267 hitters. Their pitching staff has walked 528 opposing hitters and their FIP comes in at 4.18 as a squad on the campaign.

Padres relief pitchers have entered the contest with players on base 150 times in addition to having 184 appearances in high leverage situations. The bullpen have accumulated 102 holds on the campaign (6th in the league). The Padres relief pitchers have accumulated a save percentage of 71.2% and stepped onto the hill in 172 save situations. They have earned 47 saves this season and have not converted 19 out of their 66 save opportunities. The bullpen pitchers have inherited 243 runners on the campaign and 31.3% of those runners ended up scoring. The Padres have sent 529 relief pitchers to the mound so far this year.

The San Diego Padres have a total of 4,150 putouts this season, as well as 1,381 assists and 63 errors. Their fielding rate is holding at .989 which puts them in 3rd in MLB, and they have turned 126 double plays. The Padres have transformed 70.7% of balls hit into play into outs out of 12,450 innings, which has them ranked 10th in the majors.

Ray has taken the ball for 1,480 frames and has tallied 1,765 strikeouts in his MLB career. His earned run average is 3.98 (654 ER's allowed) and his WHIP is 1.294. He has surrendered 1,282 hits (7.8 hits per nine innings) and has had 634 walks. Ray (91-83 career win-loss mark) is the owner of a FIP of 3.92 and he has faced 6,270 opposing hitters in the major leagues.

The Dodgers have a slugging percentage of .426 and they average 5.00 runs per game (4th in the league). They have hit 258 doubles, while getting a free base 607 times and earning 780 runs. Los Angeles is sitting with 197 HRs this season and 736 RBIs. They have been called out on strikes on 1,215 occasions (27th in the league) and have tallied 1,349 hits. The Los Angeles Dodgers have compiled a team OBP of .339 as well as a team batting average of .257 so far this year.

The Dodgers have a team WHIP of 1.155 and are the owners of a FIP of 3.77 as a squad so far this season. They rank 1st in the league as a staff in total hits relinquished with 1,123. The Los Angeles pitching staff have surrendered 587 runs this year and come in with a team ERA of 3.62 (555 earned runs yielded). Their strikeout to walk ratio sits at 9.50 (1,450 strikeouts against 471 walks). They have given up 171 home runs and they surrender 3.83 runs per 9 innings (2nd in the league).

They are ranked 13th in baseball holding a save rate of 66.7%, and they have dispatched 512 relief pitchers to the hill this year. Their relievers have come in 166 times in high leverage situations and also on 110 occasions with runners on base. Sitting with 166 save situations, the Dodgers have recorded 99 holds and 22 blown saves. Los Angeles has had bullpen pitchers take the mound in 66 save chances and they have come away with 44 saves. Los Angeles relievers have an inherited score percentage of 35.0% out of 177 inherited base runners.

The Los Angeles Dodgers have gotten 87 double plays and have a fielding percentage of .989 (4th in MLB). The Dodgers have recorded 1,243 assists, 62 errors and have a tally of 4,142 putouts this year. In their 12,426 innings on the diamond, the Dodgers have a efficiency on defense of 72.1% (2nd in MLB).

During his MLB career, Yamamoto has surrendered 305 hits while he has accumulated 484 punch outs in 442 innings pitched. Yamamoto (33-18 record in his career) holds a 2.61 earned run average while giving up 6.2 hits per 9 innings. He has conceded a total of 128 earned runs while holding a WHIP of 0.966 and a FIP of 2.6. He has a strikeout to walk ratio of 3.97 and he has faced 1,734 batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Los Angeles (-182)

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