San Diego Padres vs Milwaukee Brewers Prediction, 5/12/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Milwaukee Brewers

Date: Tuesday, May 12, 2026

Location: American Family Field in Milwaukee, WI

TV: Brewers.TV

Odds/Point Spread: San Diego (+125) Milwaukee (-145)

American Family Field is the location where the Milwaukee Brewers (22-16) will attempt to beat the San Diego Padres (24-16) on Tuesday. The line on this contest has San Diego at +125 and Milwaukee is sitting at -145. The total comes in at 8.5. The pitchers taking the mound will be Matt Waldron and Brandon Sproat.

San Diego is slugging .370 and have struck out 333 times, while drawing a walk on 131 occasions. They have accounted for 163 runs batted in in addition to 292 base knocks this season, while their team batting average sits at .223. The Padres have earned 62 doubles as a team and have smacked 39 baseballs out of the park. They have accumulated 170 runs while holding a team OBP of .297. As a squad, the San Diego Padres are putting up 4.3 runs per game, which has them sitting at 20th in the league.

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They have a strikeout to walk ratio of 2.69 and their pitching staff holds a collective WHIP of 1.23. Padres pitchers have given up 35 home runs and 167 runs in total (8th in MLB). San Diego has conceded 312 base knocks (7.8 per 9 innings) as well as 162 earned runs. The Padres have compiled a team earned run average of 4.07 for the season (16th in baseball), and the staff has struck out 350 hitters. Their pitching staff has walked 130 opposing hitters and their FIP comes in at 3.68 as a team for the year.

The Padres have dispatched 134 relief pitchers to the mound for the season. The relievers have inherited 61 runners over the course of the season with 36.1% of those runners ended up crossing the plate. The relievers have racked up 28 holds for the year (6th in MLB). Padres relief pitchers have entered the game with runners on base 36 times as well as having 44 appearances in high leverage situations. They have 14 saves on the campaign and have not converted 7 of their 21 save opportunities. The Padres relief pitchers have accumulated a save rate of 66.7% and stepped onto the hill in 51 save situations.

The Padres have converted 70.7% of balls in play into outs out of 3,222 innings, which has them sitting 11th in the majors. The San Diego Padres have accumulated 1,074 putouts so far this season, as well as 361 assists and 10 errors. Their fielding rate is currently at .993 which has them sitting 2nd in baseball, and they have turned 29 double plays.

Waldron (9-16 win-loss record in his career) is the owner of a FIP of 5.06 and he has faced 909 opposing hitters in the major leagues. He has given up 214 hits (9.2 hits per nine innings) and has had 63 free passes. His ERA is 5.13 (120 earned runs allowed) and he has a WHIP of 1.317. Waldron has thrown 210 innings and has earned 182 K's so far in his career.

The Brewers have a team SLG% of .353 and they average 5.13 runs per contest (5th in MLB). They have recorded 59 two-baggers, while walking 173 times and recording 195 runs. Milwaukee has tallied 26 long balls this season to go along with 187 runs batted in. They have struck out on 302 occasions (28th in MLB) and have 305 base hits. The Milwaukee Brewers are sitting with an OBP of .333 as well as a batting average of .240 so far this season.

The Milwaukee pitching staff have given up 141 runs on the season while having an ERA of 3.43 (129 earned runs relinquished). They have conceded 30 long balls and they surrender 3.75 runs per 9 innings (4th in the league). The Brewers have a team WHIP of 1.245 and have a FIP of 3.45 as a team this year. Their K/BB ratio is 9.70 (366 strikeouts against 140 free passes). They are currently ranked 3rd in the league as a staff in total hits conceded with 281.

They are currently ranked 13th in baseball holding a save rate of 64.7%, and they have dispatched 126 relievers to the hill this season. Their bullpen pitchers have stepped onto the hill 39 times in high leverage situations and also on 34 occasions with runners on. With 38 save situations, the Brewers have 20 holds in addition to 6 blown saves. Milwaukee has had bullpen pitchers enter the game in 17 save chances and they have recorded 11 saves. Milwaukee relievers have an inherited score rate of 36.5% out of their 52 inherited runners.

In their 3,045 innings played, the Brewers have earned a efficiency on defense of 69.6% (20th in professional baseball). The Milwaukee Brewers have turned 30 double plays and own a fielding percentage of .987 (11th in professional baseball). The Brewers have recorded 302 assists, 17 errors and have accumulated 1,015 putouts during this campaign.

Sproat (0-4 career record) has a 5.54 earned run average and has conceded 8.4 hits per 9 innings. His strikeout to walk ratio is 1.88 and he has faced 215 opposing hitters so far in his career. He has allowed 31 ER's while holding a WHIP of 1.429 and being the owner of a FIP of 5.5. During his career, Sproat has given up 47 hits while he has tallied 47 punch outs in 50 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take San Diego (+125)

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