San Diego Padres vs Pittsburgh Pirates Prediction, 4/6/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Pittsburgh Pirates

Date: Monday, April 6, 2026

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: San Diego (+125) Pittsburgh (-145)

The Pittsburgh Pirates (5-3) welcome the San Diego Padres (3-5) at PNC Park on Monday. The odds on this game have the Padres at +125 while the Pirates are priced at -145. The total has been set at 8.5. The starting pitchers will be German Marquez and Bubba Chandler.

San Diego has a slugging % of .287 and have struck out 66 times, while being walked on 27 occasions. They have 21 RBI's in addition to 49 hits for the year, and their average at the plate is .190. The Padres have accumulated 14 doubles as a unit and have knocked 3 balls out of the stadium. They have notched a total of 24 runs scored and hold an OBP of .267. As a squad, the San Diego Padres are putting up 3.0 runs per outing, which has them at 29th in baseball.

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The Padres have a team ERA of 3.93 over the course of the season (15th in MLB), and the staff has struck out 76 hitters. Padres pitchers have yielded 6 long balls in addition to 33 runs (13th in the league). They have walked 26 opposing batters and their FIP comes in at 3.32 as a squad on the year. San Diego has allowed 63 base hits (8.0 per 9 innings) as well as 31 earned runs. Their strikeout to walk ratio is 2.92 and the pitching staff has recorded a WHIP of 1.25.

Padres pitchers have stepped onto the hill with players on base 5 times as well as having 7 appearances in high leverage situations. The bullpen have a total of 4 holds on the season (19th in MLB). The bullpen pitchers have inherited 9 base runners so far this year and 88.9% of them earned a run for their team. The Padres have sent 25 relief pitchers to the mound on the year.

The Padres have turned 68.5% of baseballs in play into outs in their 639 innings on the field, ranking them 20th in pro baseball. The San Diego Padres have a tally of 213 putouts for the season, as well as 65 assists and 3 errors. Their fielding rate sits at .989 which has them ranked 9th in professional baseball, and have earned 7 double plays.

Marquez has taken the hill for 1,149 innings and has earned 1,070 strikeouts so far in his pro baseball career. His ERA is 4.69 (599 ER's allowed) and he has a career WHIP of 1.338. He has given up 1,183 hits (9.3 hits per 9 innings) with 355 free passes. Marquez (68-73 career mark) is the owner of a FIP of 4.62 and he has gone up against 4,925 hitters during his time in the majors.

Pittsburgh has knocked in 10 home runs on the year to go along with 37 RBIs. They have hit 12 doubles, while getting a free base 37 times as well as scoring 37 runs. The Pittsburgh Pirates have earned an on-base percentage of .326 in addition to a batting average of .232 for the season. The Pirates have a team slugging percentage of .384 and they earn 4.62 runs per game (12th in MLB). They have been called out on strikes on 76 instances (12th in MLB) and have tallied 64 base hits.

The Pittsburgh pitching staff have allowed 32 runs this year while holding an ERA of 3.50 (28 earned runs yielded). They have yielded 7 HR's and they give up 4.00 runs per 9 innings (9th in baseball). The Pirates have a WHIP of 1.389 and have a FIP of 4.21 as a staff this season. Their strikeout to walk ratio sits at 9.90 (79 strikeouts against 44 walks). They sit at 9th in baseball as a pitching staff in total hits given up with 56.

They are currently ranked 16th in MLB holding a save rate of 66.7%, and they have sent 32 relief pitchers to the mound so far this year. Their relievers have stepped onto the mound 14 times in high leverage situations in addition to 10 occasions with base runners.

Out of their 648 innings played, the Pirates hold a defensive efficiency of 71.5% (11th in professional baseball). The Pittsburgh Pirates have gotten 6 double plays and own a fielding percentage of .989 (10th in MLB). The Pirates have recorded 58 assists, 3 errors and have earned a total of 216 putouts for the year.

Chandler (4-1 record in his career) has a 3.58 ERA while giving up 6.4 hits per nine innings. He has a strikeout to walk ratio of 3.70 and he has faced 143 batters in his MLB career. He has surrendered a total of 14 earned runs while earning a WHIP of 0.994 and having a FIP of 3.5. So far in his career, Chandler has surrendered 25 hits and he has 37 strikeouts in 35 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (+125)

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