San Diego Padres vs Pittsburgh Pirates Prediction, 4/7/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Pittsburgh Pirates

Date: Tuesday, April 7, 2026

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: San Diego (+125) Pittsburgh (-150)

The San Diego Padres (4-5) are on their way to PNC Park on Tuesday where they will compete against the Pittsburgh Pirates (6-3). The line on this matchup has San Diego at +125 and Pittsburgh is priced at -150. The total is 9. The pitchers expected to start will be Nick Pivetta and Paul Skenes.

San Diego is slugging .324 and have been rung up 73 times, while being walked on 30 occasions. They have recorded 29 RBI's and 61 hits so far this season, while their batting average comes in at .208. The Padres have accrued 17 doubles as a squad and have knocked 5 baseballs out of the stadium. They have accumulated 32 runs scored while having a team on-base percentage of .281. As a squad, the San Diego Padres are earning 3.6 runs per game, which ranks them 24th in baseball.

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Their strikeout to walk ratio sits at 2.87 and their pitching staff holds a collective WHIP of 1.28. Padres pitchers have surrendered 6 home runs in addition to 39 total runs (14th in the league). San Diego has given up 72 hits (8.1 per 9 innings) and 37 earned runs. The Padres have an ERA of 4.16 this season (17th in MLB), and they have struck out 86 hitters. Their pitching staff has walked 30 opposing hitters and their FIP comes in at 3.22 as a squad over the course of the season.

Padres relief pitchers have entered the contest with runners on base 7 times in addition to having 9 appearances in high leverage situations. The bullpen have accumulated 5 holds so far this season (16th in MLB). They have tallied 4 saves on the campaign and have missed out on 4 of their 8 save opportunities. The relievers have inherited 11 runners on the season with 90.9% of those players crossing home plate. The Padres have sent 30 relief pitchers to the hill on the campaign.

The Padres have turned 68.1% of balls hit into play into outs out of 720 innings on the field, ranking them 23rd in professional baseball. The San Diego Padres have a tally of 240 putouts over the course of the season, in addition to 75 assists and 3 errors. Their fielding percentage sits at .991 which is 9th in baseball, and have earned 7 double plays.

Pivetta has thrown 1,219 innings and is sitting with 1,341 strikeouts during his MLB career. Pivetta (70-77 career mark) has a FIP of 4.42 while going up against 5,144 opposing batters during his time in the majors. His ERA is 4.49 (608 earned runs allowed) and his WHIP is 1.269. He has given up 1,115 hits (8.2 hits per 9 innings) and has 432 free passes.

The Pirates hold a slugging percentage of .399 and they earn 5.00 runs per contest (7th in baseball). They have notched 13 doubles, while walking 42 times as well as recording 45 runs. Pittsburgh has hit 12 home runs this season to go along with 45 runs batted in. They have struck out on 79 instances (20th in the league) and have totaled 74 base hits. The Pittsburgh Pirates have a team OBP of .337 and a team batting average of .240 over the course of the season.

The Pittsburgh pitching staff have surrendered 34 runs so far this year while holding an ERA of 3.33 (30 earned runs yielded). They have given up 7 home runs and they relinquish 3.78 runs per 9 innings (9th in baseball). The Pirates have a team WHIP of 1.333 and are the owners of a FIP of 3.77 as a team this season. Their K/BB ratio comes in at 10.30 (93 strikeouts vs 44 walks). They come in at 7th in baseball as a staff in total hits given up with 64.

Their bullpen pitchers have stepped onto the hill 14 times in high leverage situations and on 10 occasions with base runners. With 10 save situations, the Pirates have earned 7 holds and also 1 blown save. They rank 16th in baseball holding a save percentage of 66.7%, and they have dispatched 34 relievers to the mound over the course of the season.

In 729 innings played, the Pirates have earned a efficiency on defense of 70.3% (13th in pro baseball). The Pittsburgh Pirates have turned 7 double plays and hold a fielding percentage of .990 (11th in baseball). The Pirates have recorded 65 assists, 3 errors and have a tally of 243 putouts this season.

During his pro baseball career, Skenes has surrendered 237 base hits while he has totaled 392 K's in 325 frames. He has surrendered 76 ER's while earning a WHIP of 0.968 and being the owner of a FIP of 2.1. His strikeout to walk ratio is 5.03 and he has faced 1,276 hitters during his pro baseball career. Skenes (22-14 career record) has earned a 2.10 ERA while surrendering 6.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Pittsburgh (-150)

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