San Diego Padres vs San Francisco Giants Prediction, 9/12/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs San Francisco Giants

Date: Saturday, September 12, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: San Diego (-128) San Francisco (+106)

Oracle Park is the location where the San Francisco Giants (62-85) will take on the San Diego Padres (78-68) on Saturday. The odds on this game have the Padres at -128 and the Giants are sitting at +106. The total is 9. The expected starting pitchers are Michael King and Cesar Perdomo.

As a unit, the San Diego Padres are notching 4.2 runs per contest, which puts them at 23rd in the league. They are sitting with 619 runs scored while holding a team on-base percentage of .315. The Padres have accounted for 208 doubles as a squad and have smacked 161 baseballs out of the park. They have amassed 596 runs batted in and 1,142 base knocks this year, while their team batting average is .238. San Diego has a slugging % of .388 and have been called out on strikes 1,178 times, while taking a walk on 505 occasions.

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The Padres hold a team ERA of 3.88 so far this year (9th in the league), and they have rung up 1,189 batters. Padres pitchers have allowed 160 home runs and also 602 total runs (7th in MLB). They have walked 493 opposing batters and their FIP is 4.15 as a team this season. San Diego has yielded 1,162 base hits (8.1 per 9 innings) in addition to 558 earned runs. They have accumulated a K/BB ratio of 2.41 and their pitching staff has recorded a WHIP of 1.28.

Padres bullpen pitchers have entered the contest with runners on base 141 times in addition to having 166 appearances in high leverage situations. The relief pitchers have earned 90 holds on the campaign (8th in MLB). The Padres relief pitchers have recorded a save percentage of 70.5% and have entered the game in 154 save situations. They have accumulated 43 saves on the year and have blown 18 of their 61 save chances. The bullpen pitchers have inherited 231 runners so far this year and 31.2% of those runners earned a run for their team. The Padres have dispatched 494 relievers to the hill on the year.

The San Diego Padres have amassed 3,880 putouts on the year, as well as 1,292 assists and 61 errors. Their fielding rate sits at .988 which is 4th in MLB, and they have turned 116 double plays. The Padres have transformed 70.8% of baseballs in play into outs out of 11,640 innings, ranking them 9th in MLB.

King (41-38 career mark) has earned a FIP of 3.13 and he has faced 2,755 batters during his time in the majors. He has given up 548 hits (7.4 hits per nine innings) and has 238 walks. His earned run average is 3.18 (234 earned runs allowed) and his career WHIP is 1.187. King has taken the hill for 662 frames and is sitting with 703 K's so far in his MLB career.

The Giants hold a team slugging percentage of .407 and they are earning 4.20 runs per contest (24th in MLB). They have hit 244 two-baggers, while getting a free base 406 times as well as earning 617 runs. San Francisco has knocked in 166 HRs this season to go along with 596 RBIs. They have struck out on 1,177 occasions (22nd in the league) and have tallied 1,234 hits. The San Francisco Giants have compiled an on-base percentage of .309 and a batting average of .248 so far this year.

The San Francisco pitching staff have conceded 689 runs this season while having a team ERA of 4.34 (626 earned runs allowed). They have allowed 140 home runs and they surrender 4.78 runs per 9 innings (23rd in MLB). The Giants hold a team WHIP of 1.357 and are the owners of a FIP of 4.22 as a squad this year. Their strikeout to walk ratio is 7.60 (1,099 strikeouts vs 547 free passes). They are sitting at 17th in baseball as a staff in total hits given up with 1,213.

Sitting with 132 save situations, the Giants have earned 80 holds and also 24 blown saves. San Francisco has called on relief pitchers to take the mound in 52 save opportunities and they have come away with 28 saves. San Francisco relievers hold an inherited score percentage of 35.4% of 257 inherited base runners. Their relievers have stepped onto the hill 127 times in high leverage situations and also on 165 occasions with runners on. They rank 27th in the league with a save rate of 53.8%, and they have dispatched 467 relievers to the hill for the season.

The San Francisco Giants have gotten 134 double plays and own a fielding percentage of .982 (30th in pro baseball). The Giants have 1,382 assists, 98 errors and have earned a total of 3,891 putouts during this campaign. In their 11,673 innings played, the Giants have earned a efficiency on defense of 69.6% (16th in pro baseball).

Perdomo (0-0 mark in his career) has earned a 0.90 ERA and has allowed 5.4 hits per 9 innings. His K/BB ratio is 4.00 and he has gone up against 35 batters in his pro baseball career. He has allowed 1 ER's while earning a WHIP of 0.800 and a FIP of 0.9. In his pro baseball career, Perdomo has allowed 6 hits while earning 8 punch outs in 10 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Francisco (+106)

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