San Diego Padres vs Seattle Mariners Prediction, 5/15/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Seattle Mariners

Date: Friday, May 15, 2026

Location: T-Mobile Park in Seattle, WA

TV: MLB.TV

Odds/Point Spread: San Diego (+126) Seattle (-152)

The San Diego Padres (25-17) are on their way to T-Mobile Park on Friday where they will attempt to defeat the Seattle Mariners (21-23). The moneyline on this contest has the Padres at +126 and the Mariners open at -152. The over/under is set at 8. The starting pitchers will be Randy Vasquez and Emerson Hancock.

The Padres have accounted for 63 two-baggers as a squad and have hit 41 baseballs out of the park. San Diego has a slugging rate of .367 and have been called out on strikes 359 times, while being walked on 135 occasions. As a team, the San Diego Padres are scoring 4.2 runs per game, which is 18th in MLB. They have 170 runs batted in as well as 306 hits this year, and their team batting average is at .222. They have earned a total of 177 runs while having a team OBP of .295.

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Their strikeout to walk ratio is 2.73 and their pitching staff has earned a collective WHIP of 1.24. Padres pitchers have yielded 36 home runs and 174 runs in total (10th in MLB). San Diego has yielded 332 base hits (8.0 per 9 innings) and also 169 earned runs. The Padres have compiled a team earned run average of 4.06 on the campaign (16th in MLB), and the staff has struck out 366 batters. Their pitching staff has walked 134 opposing hitters and their FIP comes in at 3.63 as a team on the year.

The Padres relievers have compiled a save rate of 68.2% and have stepped onto the mound in 52 save situations. They have earned 15 saves over the course of the season and have missed out on 7 out of their 22 chances to save the game. The bullpen pitchers have inherited 65 base runners so far this season with 33.8% of those players crossing the plate. Padres pitchers have stepped onto the hill with runners on base 38 times in addition to having 46 appearances in high leverage situations. The Padres have sent 140 relief pitchers to the hill this year. The bullpen have recorded 28 holds this season (7th in MLB).

The San Diego Padres have accumulated 1,125 putouts at this point in the season, as well as 383 assists and 10 errors. Their fielding rate is holding steady at .993 which has them sitting 1st in professional baseball, and they have turned 31 double plays. The Padres have converted 70.3% of balls hit into play into outs out of 3,375 innings, which ranks them 14th in MLB.

Vasquez has taken the hill for 313 frames and has 215 strikeouts in his career. Vasquez (16-17 record in his career) has a FIP of 3.88 and he has faced 1,348 batters in the major leagues. His ERA is 3.94 (137 ER's allowed) and his WHIP is 1.357. He has conceded 313 hits (9.0 hits per 9 innings) and has 112 free passes.

The Mariners have a team slugging % of .380 and they are earning 4.16 runs per game (24th in baseball). They have recorded 57 two-baggers, while taking a walk 171 times as well as putting up 183 runs. Seattle has a total of 51 home runs so far this season as well as 178 runs batted in. They have struck out on 401 occasions (4th in baseball) and have 335 hits. The Seattle Mariners have accumulated an on-base percentage of .320 in addition to a team batting average of .230 for the season.

The Seattle pitching staff have relinquished 172 runs on the year while holding a team ERA of 3.64 (158 earned runs relinquished). They have yielded 44 homers and they concede 3.96 runs per 9 innings (6th in the league). The Mariners have a WHIP of 1.232 and have a FIP of 3.68 as a staff for the season. They currently have a K/BB ratio of 8.60 (376 strikeouts vs 108 walks). They come in at 25th in baseball as a pitching staff in total hits allowed with 374.

Seattle relievers have an inherited score rate of 13.3% of 45 inherited base runners. Their relievers have stepped onto the mound 59 times in high leverage situations and also on 34 occasions with runners on. Sitting with 43 save situations, the Mariners have 24 holds and 7 blown saves. They sit at 16th in MLB holding a save percentage of 63.2%, and they have sent 139 relief pitchers to the hill for the year.

In 3,522 innings on the field, the Mariners hold a defensive efficiency of 68.6% (25th in baseball). The Seattle Mariners have turned 42 double plays and have notched a fielding percentage of .990 (5th in MLB). The Mariners have racked up 366 assists, 16 errors and have earned 1,174 putouts so far this year.

Thus far in his career, Hancock has given up 207 hits while accumulating 159 strikeouts in 209 innings pitched. Hancock (11-10 career record) has a 4.47 ERA while giving up 8.9 hits per 9 innings. He has allowed 104 earned runs while holding a WHIP of 1.285 and a FIP of 4.4. He has a strikeout to walk ratio of 2.56 and he has faced 885 hitters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Seattle (-152)

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