San Diego Padres vs Seattle Mariners Prediction, 5/16/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Seattle Mariners

Date: Saturday, May 16, 2026

Location: T-Mobile Park in Seattle, WA

TV: MLB.TV

Odds/Point Spread: San Diego (+102) Seattle (-122)

T-Mobile Park is where the Seattle Mariners (22-23) will go up against the San Diego Padres (25-18) on Saturday. The odds on this game have the Padres at +102 and the Mariners are opening at -122. The total is set at 9. The pitchers taking the mound are Lucas Giolito and Logan Gilbert.

San Diego has a slugging % of .365 and have struck out 369 times, while taking a walk on 138 occasions. They have earned 171 RBI's in addition to 313 base knocks on the year, while their team batting average comes in at .222. The Padres have tallied 65 doubles as a unit and have knocked 41 balls out of the stadium. They have earned a total of 178 runs scored while holding a team OBP of .294. As a squad, the San Diego Padres are scoring 4.1 runs per game, which has them at 24th in the league.

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The Padres have a team ERA of 4.14 on the campaign (16th in baseball), and the staff has struck out 377 hitters. Padres pitchers have conceded 36 long balls in addition to 181 runs in total (11th in MLB). They have walked 141 players from the other team and their FIP sits at 3.61 as a team this season. San Diego has yielded 342 base hits (8.0 per 9 innings) and also 176 earned runs. They have accrued a K/BB ratio of 2.67 and the pitching staff has earned a collective WHIP of 1.26.

The Padres have dispatched 143 relievers to the mound so far this season. The relievers have inherited 66 base runners on the campaign and 33.3% of those runners crossing the plate. The relief pitchers have accumulated 28 holds this season (7th in the league). Padres relief pitchers have come into the game with players on base 39 times as well as having 46 appearances in high leverage situations. They have tallied 15 saves for the season and have missed out on 7 out of their 22 save chances. The Padres relief pitchers have a save percentage of 68.2% and have entered the game in 52 save situations.

The Padres have converted 69.8% of balls in play into outs in their 3,447 innings, ranking them 19th in pro baseball. The San Diego Padres have accounted for 1,149 putouts on the campaign, as well as 389 assists and 12 errors. Their fielding rate is currently at .992 which ranks 1st in baseball, and they have turned 31 double plays.

Giolito has pitched in 1,158 innings and is sitting with 1,198 K's during his pro baseball career. His earned run average is 4.30 (554 ER's allowed) and his WHIP is 1.259. He has given up 1,017 base hits (7.9 hits per 9 innings) and has 441 free passes. Giolito (71-66 record in his career) is the owner of a FIP of 4.24 while facing 4,873 opposing hitters in the major leagues.

Seattle has tallied 53 home runs on the campaign as well as 186 runs batted in. They have recorded 61 doubles, while getting a free base 176 times as well as scoring 191 runs. The Seattle Mariners have an OBP of .322 in addition to a team batting average of .232 for the season. The Mariners hold a slugging percentage of .386 and they tally 4.24 runs per game (18th in the league). They have been called out on strikes on 407 instances (3rd in MLB) and have earned a total of 346 base knocks.

The Seattle pitching staff have surrendered 175 runs on the season while having a team ERA of 3.62 (161 earned runs given up). They have relinquished 45 home runs and they surrender 3.94 runs per 9 innings (6th in the league). The Mariners hold a team WHIP of 1.230 in addition to having a FIP of 3.70 as a staff so far this season. They currently have a K/BB ratio of 8.60 (384 strikeouts vs 113 bases on balls). They come in at 25th in baseball as a staff in total hits given up with 379.

Sitting with 43 save situations, the Mariners have 24 holds and 7 blown saves. Seattle has had relievers take the mound in 19 save chances and they have earned 12 saves. Seattle relievers hold an inherited score percentage of 13.0% out of 46 inherited runners. Their relievers have stepped onto the mound 59 times in high leverage situations in addition to 35 occasions with runners on base. They are currently ranked 16th in MLB with a save percentage of 63.2%, and they have sent 141 bullpen pitchers onto the field for the year.

The Seattle Mariners have gotten 42 double plays and have earned a fielding percentage of .990 (4th in baseball). The Mariners have recorded 378 assists, 16 errors and are sitting with 1,201 putouts on the season. In 3,603 innings played, the Mariners have accumulated a defensive efficiency of 68.9% (24th in MLB).

Gilbert (49-39 career record) has a 3.59 ERA and has surrendered 7.6 hits per nine innings. He has a K/BB ratio of 4.90 and he has gone up against 3,581 batters thus far in his career. He has allowed a total of 353 ER's while earning a WHIP of 1.064 and a FIP of 3.5. So far in his career, Gilbert has allowed 751 hits while he has totaled 936 strikeouts in 885 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take San Diego (+102)

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