San Francisco Giants vs Cincinnati Reds Prediction, 4/15/2026 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs Cincinnati Reds

Date: Wednesday, April 15, 2026

Location: Great American Ball Park in Cincinnati, OH

TV: Reds.TV

Odds/Point Spread: San Francisco (+150) Cincinnati (-182)

The San Francisco Giants (6-10) are hitting the road to Great American Ball Park on Wednesday where they will attempt to beat the Cincinnati Reds (9-7). The moneyline on this matchup has the Giants at +150 while the Reds are opening at -182. The total is 8. The expected starting pitchers will be Tyler Mahle and Rhett Lowder.

San Francisco has a slugging % of .357 and have struck out 123 times, while drawing a walk on 33 occasions. They have recorded 48 RBI's and 129 base knocks for the season, while their team batting average comes in at .243. The Giants have accrued 28 doubles as a unit and have hit 8 baseballs out of the stadium. They have notched a total of 51 runs while holding a team on-base percentage of .288. As a squad, the San Francisco Giants are notching 3.2 runs per outing, which has them sitting at 29th in baseball.

Get all of our MLB Picks Today

They have a K/BB ratio of 2.28 and the pitching staff has a collective WHIP of 1.39. Giants pitchers have surrendered 14 home runs and also 72 total runs (23rd in MLB). San Francisco has surrendered 135 base hits (8.6 per 9 innings) and 67 earned runs. The Giants have an ERA of 4.28 this year (23rd in the league), and the staff has struck out 139 batters. They have walked 61 opposing players and their FIP sits at 3.80 as a squad this year.

The Giants bullpen have a save percentage of 50.0% and stepped onto the hill in 10 save situations. They have recorded 2 saves so far this year and have blown 2 out of their 4 save chances. The bullpen pitchers have inherited 32 base runners this year and 31.3% of them earned a run for their team. Giants bullpen pitchers have gone to the mound with runners on base 19 times as well as having 4 appearances in high leverage situations. The Giants have dispatched 55 relief pitchers to the hill on the campaign. The bullpen have 6 holds on the season (25th in MLB).

The Giants have turned 67.5% of baseballs in play into outs out of their 1,269 innings on the field, ranking them 27th in baseball. The Seattle Mariners have amassed 423 putouts on the campaign, in addition to 153 assists and 10 errors. Their fielding rate sits at .983 which puts them in 22nd in the majors, and they have turned 16 double plays.

Mahle (39-48 career mark) has earned a FIP of 4.01 and he has faced 3,186 hitters in the major leagues. He has surrendered 697 hits (8.4 hits per nine innings) and has 271 walks. His earned run average is 4.07 (339 earned runs allowed) and he has a WHIP of 1.292. Mahle has pitched in 749 frames and has earned 768 punch outs during his pro baseball career.

The Reds hold a team slugging % of .325 and they are recording 3.38 runs per contest (27th in the league). They have 17 doubles, while walking 69 times as well as racking up 54 runs. Cincinnati has 15 long balls this year to go along with 46 runs batted in. They have been rung up on 145 occasions (8th in baseball) and have earned a total of 109 hits. The Cincinnati Reds are sitting with a team OBP of .298 in addition to a batting average of .205 so far this season.

The Reds are sitting with a team WHIP of 1.400 and have a FIP of 4.54 as a unit so far this season. They are currently ranked 19th in the league as a pitching staff in total hits conceded with 125. The Cincinnati pitching staff have conceded 70 runs this season while having a team ERA of 4.03 (65 earned runs yielded). Their strikeout to walk ratio sits at 8.00 (129 strikeouts vs 78 bases on balls). They have given up 16 homers and they allow 4.34 runs per 9 innings (15th in MLB).

They sit at 8th in the league with a save rate of 75.0%, and they have dispatched 61 relievers to the hill this year. Their relief pitchers have come in 23 times in high leverage situations in addition to 21 occasions with runners on base. With 24 save situations, the Reds have earned 15 holds in addition to 2 blown saves. Cincinnati has called on bullpen pitchers to step onto the hill in 8 save opportunities and they have earned 6 saves. Cincinnati bullpen pitchers have an inherited score percentage of 20.7% of 29 inherited runners.

The Cincinnati Reds have gotten 15 double plays and hold a fielding percentage of .988 (9th in MLB). The Reds have 139 assists, 7 errors and have earned 435 putouts this year. In 1,305 innings on the field, the Reds hold a defensive efficiency of 71.6% (6th in MLB).

So far in his pro baseball career, Lowder has allowed 39 base hits while he has tallied 33 strikeouts in 46 frames. He has conceded 10 ER's while earning a WHIP of 1.274 and being the owner of a FIP of 1.9. His strikeout to walk ratio is 1.65 and he has faced 197 batters so far in his pro baseball career. Lowder (3-3 record in his career) has earned a 1.94 ERA while surrendering 7.6 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (-182)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.