San Francisco Giants vs Cincinnati Reds Prediction, 4/16/2026 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs Cincinnati Reds

Date: Thursday, April 16, 2026

Location: Great American Ball Park in Cincinnati, OH

TV: Reds.TV

Odds/Point Spread: San Francisco (+110) Cincinnati (-132)

Great American Ball Park is the site where the Cincinnati Reds (10-7) will play the San Francisco Giants (6-11) on Thursday. The line on this matchup has the Giants at +110 and the Reds are priced at -132. The betting total comes in at 8. The pitchers taking the mound are Landen Roupp and Chase Burns.

The Giants have earned 29 doubles as a team and have knocked 9 balls out of the stadium. San Francisco has a slugging rate of .355 and have struck out 128 times, while drawing a walk on 34 occasions. As a team, the San Francisco Giants are recording 3.1 runs per game, which puts them at 30th in MLB. They have accumulated 49 RBI's in addition to 136 base knocks for the year, while their team batting average is at .242. They have notched a total of 52 runs scored and hold an OBP of .286.

Get all of our MLB Betting Picks

They have accumulated a K/BB ratio of 2.24 and the pitching staff has a team WHIP of 1.37. Giants pitchers have conceded 16 home runs and 74 runs in total (16th in MLB). San Francisco has relinquished 138 hits (8.3 per 9 innings) and 69 earned runs. The Giants hold a team earned run average of 4.17 for the season (19th in the league), and they have struck out 148 hitters. They have walked 66 batters and their FIP sits at 3.94 as a squad so far this year.

The Giants bullpen have a save rate of 50.0% and have stepped onto the mound in 10 save situations. They have compiled 2 saves on the year and have blown 2 out of their 4 save opportunities. The relief pitchers have inherited 32 runners on the campaign and 31.3% of them crossing home plate. Giants relief pitchers have gone to the mound with runners on 19 times as well as having 4 appearances in high leverage situations. The Giants have sent 55 relievers to the hill for the season. The relievers have recorded 6 holds this year (25th in baseball).

The Seattle Mariners have earned 447 putouts this season, as well as 160 assists and 10 errors. Their fielding rate is currently at .984 which puts them in 18th in MLB, and have accumulated 18 double plays. The Giants have turned 68.3% of baseballs in play into outs out of their 1,341 innings, which ranks them 23rd in pro baseball.

Roupp (10-10 career win-loss mark) sits with a FIP of 3.63 while he has gone up against 762 batters in the majors. He has surrendered 170 base knocks (8.8 hits per nine innings) and has 76 walks. His earned run average is 3.69 (71 earned runs allowed) and his WHIP is 1.420. Roupp has taken the ball for 173 frames and is sitting with 167 punch outs in his MLB career.

The Reds hold a team SLG% of .327 and they are scoring 3.29 runs per game (27th in baseball). They have notched 17 doubles, while getting a free base 74 times and notching 56 runs. Cincinnati has a total of 17 home runs on the season and 48 runs batted in. They have been rung up on 154 occasions (11th in MLB) and have a total of 112 base hits. The Cincinnati Reds have accounted for an on-base percentage of .297 and a batting average of .201 this year.

The Reds have a WHIP of 1.370 with a FIP of 4.53 as a team over the course of the season. Their strikeout to walk ratio comes in at 7.80 (134 strikeouts vs 79 walks). They rank 11th in MLB as a staff in total hits surrendered with 132. They have surrendered 17 dingers and they allow 4.15 runs per 9 innings (11th in MLB). The Cincinnati pitching staff have allowed 71 runs for the season and come in with a team ERA of 3.86 (66 earned runs relinquished).

Cincinnati relievers hold an inherited score rate of 20.7% of 29 inherited runners. Their relief pitchers have come in 23 times in high leverage situations and on 21 occasions with runners on. With 24 save situations, the Reds have earned 15 holds and 2 blown saves. They sit at 8th in the league holding a save percentage of 75.0%, and they have sent 61 relief pitchers onto the diamond for the year.

The Cincinnati Reds have gotten 16 double plays and hold a fielding percentage of .987 (10th in baseball). The Reds have recorded 150 assists, 8 errors and are sitting with 462 putouts so far this year. Out of their 1,386 innings on the field, the Reds have accumulated a defensive efficiency of 71.9% (6th in professional baseball).

Burns (1-4 win-loss mark in his career) has a 4.26 ERA while allowing 8.2 hits per nine innings. He has a K/BB ratio of 3.54 and he has gone up against 258 hitters during his pro baseball career. He has surrendered 28 ER's while holding a WHIP of 1.318 and being the owner of a FIP of 4.2. So far in his pro baseball career, Burns has allowed 54 base knocks and he has 85 strikeouts in 59 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (-132)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.