San Francisco Giants vs Los Angeles Dodgers Prediction, 9/18/2026 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs Los Angeles Dodgers

Date: Friday, September 18, 2026

Location: Dodger Stadium in Los Angeles, CA

TV: Spectrum SportsNet LA

Odds/Point Spread: San Francisco (+132) Los Angeles (-160)

The San Francisco Giants (64-89) are en route to Dodger Stadium on Friday where they will play the Los Angeles Dodgers (92-60). The moneyline on this matchup has San Francisco at +132 while Los Angeles is coming in at -160. The total comes in at 8.5. The starting pitchers are Cesar Perdomo and Tyler Glasnow.

As a squad, the San Francisco Giants are earning 4.2 runs per game, which puts them at 23rd in MLB. They have a total of 649 runs scored while holding a team OBP of .310. The Giants have accrued 252 doubles as a squad and have knocked 175 baseballs out of the park. They have accrued 626 runs batted in in addition to 1,288 hits so far this season, while their batting average is .248. San Francisco has a slugging % of .408 and have been called out on strikes 1,233 times, while taking a walk on 429 occasions.

Get all of our MLB Parlay Picks

They have a K/BB ratio of 2.00 and their pitching staff has earned a collective WHIP of 1.36. Giants pitchers have surrendered 144 home runs in addition to 719 runs in total (23rd in baseball). San Francisco has surrendered 1,265 base knocks (8.4 per 9 innings) and 652 earned runs. The Giants hold a team ERA of 4.34 so far this season (23rd in baseball), and they have struck out 1,142 hitters. Their pitching staff has walked 571 opposing hitters and their FIP sits at 4.20 as a team so far this season.

The Giants relief pitchers have earned a save percentage of 53.7% and have stepped onto the mound in 137 save situations. They have tallied 29 saves for the year and have missed out on 25 of their 54 chances to save the game. The relief pitchers have inherited 271 runners for the season with 34.7% of them ended up scoring. Giants relief pitchers have gone to the mound with runners on 174 times as well as having 133 appearances in high leverage situations. The Giants have dispatched 488 relief pitchers to the hill this season. The relievers have notched 83 holds on the campaign (15th in the league).

The Giants have turned 69.6% of balls hit into play into outs in their 12,159 innings on the diamond, which ranks them 17th in baseball. The San Francisco Giants have amassed 4,053 putouts so far this season, as well as 1,435 assists and 102 errors. Their fielding percentage is at .982 which puts them in 30th in professional baseball, and they have turned 137 double plays.

Perdomo has thrown 14 frames and has 11 K's in his career. Perdomo (0-1 career mark) is the owner of a FIP of 3.75 while he has faced 61 opposing batters during his time in the majors. His ERA is 3.80 (6 ER's allowed) and he has a career WHIP of 1.408. He has conceded 16 base hits (10.1 hits per nine innings) with 4 walks.

Los Angeles has compiled 188 long balls for the season as well as 707 runs batted in. They have hit 246 two-baggers, while getting a free base 591 times as well as putting up 751 runs. The Los Angeles Dodgers have accounted for an OBP of .337 and a team batting average of .255 on the campaign. The Dodgers have a team slugging % of .420 and they are recording 4.94 runs per outing (4th in the league). They have struck out on 1,195 instances (26th in the league) and have tallied 1,300 base hits.

The Los Angeles pitching staff have allowed 578 runs on the year while holding an ERA of 3.66 (546 earned runs conceded). They have conceded 168 homers and they surrender 3.87 runs per 9 innings (2nd in the league). The Dodgers have a team WHIP of 1.164 in addition to having a FIP of 3.81 as a pitching staff over the course of the season. Their K/BB ratio is 9.40 (1,403 strikeouts against 463 bases on balls). They are currently ranked 1st in the league as a staff in total hits allowed with 1,102.

Los Angeles bullpen pitchers hold an inherited score percentage of 35.0% out of their 177 inherited runners. Their relievers have taken the field 162 times in high leverage situations in addition to 110 occasions with base runners. With 161 save situations, the Dodgers have accumulated 95 holds in addition to 22 blown saves. They are currently ranked 13th in MLB with a save percentage of 66.2%, and they have dispatched 498 relievers to the hill this year.

The Los Angeles Dodgers have turned 86 double plays and hold a fielding percentage of .989 (3rd in baseball). The Dodgers have 1,224 assists, 59 errors and have a tally of 4,034 putouts this year. In their 12,102 innings played, the Dodgers are sitting with a defensive efficiency of 72.0% (2nd in professional baseball).

So far in his MLB career, Glasnow has given up 614 hits while tallying 1,029 strikeouts in 815 innings. Glasnow (47-37 career mark) has earned a 3.72 ERA and has conceded 6.8 hits per nine innings. He has given up 337 earned runs while holding a WHIP of 1.135 and having a FIP of 3.7. He has a K/BB ratio of 3.31 and he has gone up against 3,326 batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Francisco (+132)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.