San Francisco Giants vs San Diego Padres Prediction, 4/1/2026 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs San Diego Padres

Date: Wednesday, April 1, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: San Francisco (+220) San Diego (-275)

The San Francisco Giants (1-3) are hitting the road to Petco Park on Wednesday where they will compete against the San Diego Padres (1-3). The odds on this game have the Giants at +220 while the Padres are at -275. The total comes in at 9. The starting pitchers will be Adrian Houser and Nick Pivetta.

As a unit, the San Francisco Giants are notching 1.0 runs per outing, which has them at 30th in the league. They have earned 4 runs scored while holding a team OBP of .230. The Giants have accrued 4 two-baggers as a unit and have knocked 1 baseball out of the park. They have compiled 4 RBI's in addition to 19 hits for the season, and their batting average comes in at .154. San Francisco has a slugging rate of .211 and have struck out 34 times, while drawing a walk on 10 occasions.

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Their strikeout to walk ratio is 3.64 and their pitching staff holds a collective WHIP of 1.08. Giants pitchers have surrendered 4 home runs and also 15 runs in total (12th in the league). San Francisco has relinquished 28 base hits (7.0 per 9 innings) as well as 14 earned runs. The Giants hold a team earned run average of 3.50 for the season (10th in the league), and the staff has rung up 40 batters. Their pitching staff has walked 11 opposing players and their FIP is 3.44 as a team so far this year.

Giants bullpen pitchers have entered the contest with runners on base 3 times as well as having no appearances in high leverage situations. The relief pitchers have tallied 2 holds on the season (18th in the league). The bullpen pitchers have inherited 5 runners so far this season and none of those players ended up scoring. The Giants have dispatched 17 relievers to the mound on the year.

The Seattle Mariners have earned 108 putouts thus far, as well as 39 assists and 1 error. Their fielding percentage is holding steady at .993 which has them sitting 8th in baseball, and have 3 double plays. The Giants have converted 72.0% of balls hit into play into outs out of their 324 innings on the diamond, which has them sitting at 11th in professional baseball.

Houser has taken the hill for 733 innings and has earned 576 K's in his career. Houser (40-44 win-loss record in his career) is the owner of a FIP of 4.00 while he has faced 3,137 opposing batters during his time in the major leagues. His earned run average is 4.06 (331 ER's allowed) and he has a WHIP of 1.361. He has conceded 716 hits (8.8 hits per 9 innings) and has had 282 free passes.

San Diego has knocked in 2 long balls so far this year to go along with 8 RBIs. They have 4 doubles, while getting a free base 12 times as well as putting up 9 runs. The San Diego Padres have recorded an OBP of .252 in addition to a team batting average of .181 on the season. The Padres hold a slugging percentage of .260 and they have an average of 2.25 runs per outing (29th in MLB). They have struck out on 36 instances (18th in the league) and have notched a total of 23 base hits.

The Padres have a WHIP of 1.250 and have a FIP of 3.52 as a pitching staff on the season. They have a ranking of 4th in MLB as a staff in total hits allowed with 26. The San Diego pitching staff have allowed 16 runs for the season while having an ERA of 3.75 (15 earned runs yielded). Their K/BB ratio sits at 9.80 (39 strikeouts vs 19 free passes). They have allowed 2 dingers and they concede 4.00 runs per 9 innings (14th in MLB).

Their bullpen pitchers have come in 3 times in high leverage situations and also on 2 occasions with runners on base. They are currently ranked 25th in the league with a save rate of 33.3%, and they have dispatched 13 bullpen pitchers to the hill for the season.

In 324 innings played, the Padres are sitting with a defensive efficiency of 72.7% (7th in professional baseball). The San Diego Padres have gotten 3 double plays and have accounted for a fielding rate of .993 (10th in professional baseball). The Padres have recorded 32 assists, 1 error and are sitting with 108 putouts this season.

Pivetta (69-77 career record) holds a 4.51 earned run average and has surrendered 8.3 hits per nine innings. He has a K/BB ratio of 3.10 and he has gone up against 5,126 opposing hitters during his pro baseball career. He has given up a total of 608 ER's while holding a WHIP of 1.272 and having a FIP of 4.4. During his pro baseball career, Pivetta has conceded 1,114 base hits while he has tallied 1,333 strikeouts in 1,214 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-275)

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