San Francisco Giants vs St. Louis Cardinals Prediction, 9/14/2026 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs St. Louis Cardinals

Date: Monday, September 14, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: San Francisco (-196) St. Louis (+162)

Busch Stadium is the location where the St. Louis Cardinals (73-76) will go up against the San Francisco Giants (62-87) on Monday. The odds on this game have the Giants at -196 and the Cardinals are coming in at +162. The total is 8. The expected starting pitchers will be Landen Roupp and Quinn Mathews.

As a squad, the San Francisco Giants are putting up 4.2 runs per outing, which has them sitting at 24th in MLB. They have accumulated 628 runs while holding a team on-base percentage of .308. The Giants have accumulated 246 doubles as a unit and have knocked 171 balls out of the stadium. They have accounted for 607 runs batted in and 1,248 hits on the season, and their batting average is sitting at .247. San Francisco has a slugging percentage of .408 and have been called out on strikes 1,196 times, while taking a walk on 412 occasions.

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Their strikeout to walk ratio is 1.99 and the pitching staff has a collective WHIP of 1.37. Giants pitchers have allowed 142 home runs and 703 runs in total (23rd in MLB). San Francisco has surrendered 1,238 base knocks (8.5 per 9 innings) and 639 earned runs. The Giants are sitting with a team ERA of 4.37 on the campaign (23rd in MLB), and the staff has struck out 1,111 hitters. They have walked 557 opposing hitters and their FIP sits at 4.23 as a squad for the season.

The Giants have sent 474 relief pitchers to the mound so far this season. The relief pitchers have inherited 259 runners on the year with 35.1% of those players crossing the plate. The relief pitchers have a total of 80 holds on the campaign (15th in MLB). Giants relief pitchers have entered the game with runners on 167 times in addition to having 127 appearances in high leverage situations. They have compiled 28 saves so far this year and have not converted 24 of 52 save opportunities. The Giants bullpen have a save percentage of 53.8% and have come into the game in 132 save situations.

The San Francisco Giants have a tally of 3,945 putouts this year, in addition to 1,403 assists and 100 errors. Their fielding percentage is holding steady at .982 which is 30th in professional baseball, and have accumulated 134 double plays. The Giants have converted 69.5% of balls hit into play into outs in their 11,835 innings on the field, which has them ranked 17th in MLB.

Roupp has taken the hill for 307 innings and has accumulated 288 punch outs in his pro baseball career. Roupp (17-22 mark in his career) has a FIP of 3.81 and he has faced 1,330 batters during his time in the major leagues. His ERA is 3.87 (132 ER's allowed) and he has a WHIP of 1.367. He has allowed 277 base knocks (8.1 hits per 9 innings) and has 143 walks.

St. Louis has 157 long balls this year to go along with 660 RBIs. They have tallied 216 doubles, while taking a walk 478 times as well as earning 680 runs. The St. Louis Cardinals hold an on-base percentage of .317 and a team batting average of .244 on the season. The Cardinals have a slugging percentage of .386 and they are earning 4.56 runs per game (11th in MLB). They have been called out on strikes on 1,174 instances (25th in the league) and have earned a total of 1,228 hits.

The Cardinals have a team WHIP of 1.355 with a FIP of 4.11 as a squad on the campaign. Their K/BB ratio sits at 8.00 (1,179 strikeouts vs 514 walks). They come in at 24th in baseball as a staff in total hits relinquished with 1,284. They have given up 149 HR's and they relinquish 4.67 runs per 9 innings (21st in MLB). The St. Louis pitching staff have yielded 689 runs this year while holding an ERA of 4.31 (636 earned runs conceded).

They rank 22nd in the league with a save percentage of 58.9%, and they have sent 510 relief pitchers to the hill for the season. Their relievers have come in 187 times in high leverage situations and on 154 occasions with runners on base. Sitting with 170 save situations, the Cardinals have accumulated 93 holds and also 30 blown saves. St. Louis has called on relievers to step onto the mound in 73 save chances and they have earned 43 saves. St. Louis relief pitchers have an inherited score rate of 41.2% out of their 228 inherited runners.

In 11,949 innings on the diamond, the Cardinals have a defensive efficiency of 69.0% (25th in professional baseball). The St. Louis Cardinals have gotten 143 double plays and hold a fielding percentage of .988 (5th in baseball). The Cardinals have recorded 1,387 assists, 64 errors and have a total of 3,983 putouts on the campaign.

Matthews (1-3 win-loss mark in his career) has earned a 4.17 ERA while conceding 9.5 hits per 9 innings. He has a K/BB ratio of 2.00 and he has gone up against 137 opposing batters during his career. He has surrendered 14 ER's while holding a WHIP of 1.523 and being the owner of a FIP of 4.1. So far in his career, Matthews has given up 32 hits while totaling 28 punch outs in 30 frames.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take San Francisco (-196)

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