San Francisco Giants vs St. Louis Cardinals Prediction, 9/16/2026 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs St. Louis Cardinals

Date: Wednesday, September 16, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: San Francisco (-132) St. Louis (+110)

The San Francisco Giants (62-89) are en route to Busch Stadium on Wednesday where they will go up against the St. Louis Cardinals (75-76). The odds on this game have San Francisco at -132 and St. Louis is at +110. The over/under is 9. The expected starting pitchers will be Anthony Molina and Matthew Liberatore.

The Giants have tallied 247 doubles as a team and have knocked 172 balls out of the stadium. San Francisco has a slugging % of .406 and have been called out on strikes 1,217 times, while drawing a walk on 420 occasions. As a squad, the San Francisco Giants are knocking in 4.2 runs per game, which puts them at 24th in MLB. They have 612 runs batted in and 1,263 hits on the campaign, while their batting average is sitting at .247. They have 633 runs scored while holding a team on-base percentage of .308.

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The Giants have an earned run average of 4.37 this year (23rd in the league), and their staff has struck out 1,127 batters. Giants pitchers have surrendered 143 home runs and also 711 runs (23rd in the league). They have walked 562 opposing hitters and their FIP is 4.22 as a squad over the course of the season. San Francisco has given up 1,255 base hits (8.5 per 9 innings) as well as 647 earned runs. Their K/BB ratio is 2.01 and the pitching staff has earned a collective WHIP of 1.36.

Giants bullpen pitchers have stepped onto the hill with runners on base 170 times in addition to having 129 appearances in high leverage situations. The relief pitchers are sitting with 80 holds on the season (16th in baseball). The Giants relievers have earned a save percentage of 53.8% and have come into the game in 132 save situations. They have tallied 28 saves on the season and have missed out on 24 of 52 save chances. The bullpen pitchers have inherited 265 runners for the season and 35.1% of them earned a run for their team. The Giants have dispatched 480 relievers to the mound so far this year.

The Giants have transformed 69.5% of balls in play into outs out of their 11,988 innings, ranking them 17th in MLB. The San Francisco Giants have 3,996 putouts at this point in the season, as well as 1,421 assists and 100 errors. Their fielding percentage is holding at .982 which is 30th in baseball, and they have turned 137 double plays.

Molina has taken the mound for 99 innings and has earned 67 punch outs thus far in his career. Molina (2-2 win-loss record in his career) sits with a FIP of 6.80 while facing 445 opposing hitters during his time in the majors. His ERA is 6.90 (76 earned runs allowed) and his career WHIP is 1.604. He has surrendered 130 hits (11.8 hits per nine innings) and has 29 free passes.

St. Louis has tallied 157 home runs so far this year as well as 665 RBIs. They have recorded 219 doubles, while taking a walk 482 times and putting up 685 runs. The St. Louis Cardinals have recorded an on-base percentage of .317 and a team batting average of .243 over the course of the season. The Cardinals hold a slugging percentage of .384 and they score 4.54 runs per game (12th in MLB). They have struck out on 1,189 occasions (25th in MLB) and have totaled 1,240 base hits.

The Cardinals are sitting with a team WHIP of 1.351 with a FIP of 4.09 as a pitching staff so far this season. They rank 24th in the league as a pitching staff in total hits relinquished with 1,294. The St. Louis pitching staff have conceded 691 runs for the season while holding a team ERA of 4.27 (638 earned runs yielded). Their strikeout to walk ratio comes in at 8.00 (1,200 strikeouts against 523 walks). They have given up 149 homers and they surrender 4.62 runs per 9 innings (19th in the league).

With 175 save situations, the Cardinals have accrued 96 holds in addition to 30 blown saves. St. Louis has called on bullpen pitchers to step onto the hill in 75 save opportunities and they have walked away with 45 saves. St. Louis relief pitchers hold an inherited score rate of 40.7% out of 231 inherited runners. Their relief pitchers have stepped onto the mound 190 times in high leverage situations and on 155 occasions with runners on base. They are ranked 20th in baseball holding a save rate of 60.0%, and they have dispatched 515 bullpen pitchers to the hill this season.

The St. Louis Cardinals have turned 145 double plays and have earned a fielding percentage of .988 (4th in professional baseball). The Cardinals have racked up 1,407 assists, 64 errors and have 4,037 putouts so far this season. In 12,111 innings on the diamond, the Cardinals have accumulated a defensive efficiency of 69.1% (24th in pro baseball).

Liberatore (21-38 career win-loss record) is the owner of a 4.90 ERA and has allowed 9.6 hits per 9 innings. His K/BB ratio is 2.56 and he has gone up against 2,070 opposing hitters so far in his career. He has given up a total of 260 ER's while holding a WHIP of 1.406 and having a FIP of 4.8. During his MLB career, Liberatore has given up 508 base hits while he has tallied 418 punch outs in 477 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+110)

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