Seattle Mariners vs Cleveland Guardians Prediction, 6/26/2026 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs Cleveland Guardians

Date: Friday, June 26, 2026

Location: Progressive Field in Cleveland, OH

TV: MLB.TV

Odds/Point Spread: Seattle (-145) Cleveland (+125)

The Cleveland Guardians (42-39) are hosting the Seattle Mariners (41-40) at Progressive Field on Friday. The moneyline on this contest has Seattle at -145 and Cleveland is opening at +125. The over/under is set at 9. The pitchers taking the mound will be Luis Castillo and Joey Cantillo.

Seattle owns a slugging percentage of .386 and have been rung up 691 times, while being walked on 268 occasions. They have earned 321 runs batted in and 621 hits for the season, and their average at the plate sits at .231. The Mariners have accounted for 101 doubles as a squad and have hit 100 balls out of the stadium. They have 330 runs while having a team on-base percentage of .311. As a unit, the Seattle Mariners are earning 4.1 runs per contest, which has them sitting at 24th in the league.

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Their strikeout to walk ratio is 3.41 and the pitching staff holds a WHIP of 1.19. Mariners pitchers have allowed 77 home runs and 322 total runs (7th in the league). Seattle has relinquished 650 base hits (8.1 per 9 innings) in addition to 295 earned runs. The Mariners have compiled a team ERA of 3.69 for the year (5th in MLB), and their staff has struck out 709 batters. They have walked 208 opposing batters and their FIP is 3.56 as a squad this season.

Mariners relief pitchers have entered the contest with runners on base 60 times as well as having 91 appearances in high leverage situations. The relief pitchers have earned 46 holds this season (11th in the league). The Mariners relief pitchers have recorded a save percentage of 60.6% and have come into the game in 80 save situations. They have accumulated 20 saves on the year and have blown 13 of their 33 save opportunities. The relievers have inherited 82 runners on the year and 23.2% of them crossing the plate. The Mariners have sent 244 relief pitchers to the hill over the course of the season.

The Mariners have turned 69.3% of baseballs in play into outs out of their 6,480 innings on the field, which has them sitting 22nd in pro baseball. The Seattle Mariners have 2,160 putouts at this point in the season, as well as 655 assists and 40 errors. Their fielding percentage sits at .986 which puts them in 17th in professional baseball, and have 75 double plays.

Castillo has taken the hill for 1,480 innings and has earned 1,562 strikeouts during his pro baseball career. Castillo (86-90 record in his career) has a FIP of 3.58 while he has faced 6,141 hitters in the majors. His ERA is 3.64 (598 ER's allowed) and his career WHIP is 1.189. He has conceded 1,282 base hits (7.8 hits per 9 innings) and has 478 walks.

The Guardians hold a team slugging % of .366 and they average 3.95 runs per game (28th in MLB). They have 128 doubles, while walking 309 times as well as notching 320 runs. Cleveland has recorded 75 home runs so far this season as well as 306 RBIs. They have struck out on 662 occasions (20th in the league) and have notched a total of 605 hits. The Cleveland Guardians have accumulated an on-base percentage of .313 in addition to a team batting average of .228 so far this year.

The Cleveland pitching staff have surrendered 328 runs so far this year and come in with a team ERA of 3.79 (301 earned runs relinquished). They have allowed 95 dingers and they relinquish 4.13 runs per 9 innings (8th in the league). The Guardians hold a team WHIP of 1.255 and have a FIP of 3.97 as a team on the season. Their K/BB ratio sits at 9.30 (739 strikeouts vs 264 free passes). They rank 9th in baseball as a staff in total hits conceded with 633.

With 106 save situations, the Guardians have recorded 70 holds and 8 blown saves. Cleveland has had bullpen pitchers take the mound in 35 save chances and they have earned 27 saves. Cleveland bullpen pitchers have an inherited score percentage of 26.1% out of 111 inherited base runners. Their bullpen pitchers have stepped onto the hill 100 times in high leverage situations and on 72 occasions with runners on. They sit at 2nd in the league with a save rate of 77.1%, and they have sent 261 relievers onto the diamond for the year.

In 6,435 innings on the diamond, the Guardians have accumulated a efficiency on defense of 70.1% (15th in professional baseball). The Cleveland Guardians have turned 58 double plays and have earned a fielding percentage of .987 (14th in professional baseball). The Guardians have accrued 637 assists, 37 errors and have notched a total of 2,145 putouts over the course of the season.

In his MLB career, Cantillo has conceded 188 base hits while he has totaled 228 strikeouts in 214 innings. He has conceded a total of 91 ER's while holding a WHIP of 1.318 and being the owner of a FIP of 3.8. His K/BB ratio is 2.43 and he has gone up against 904 opposing batters during his pro baseball career. Cantillo (13-10 career record) has earned a 3.83 earned run average while giving up 7.9 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Seattle (-145)

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