Seattle Mariners vs Los Angeles Angels Prediction, 9/16/2026 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs Los Angeles Angels

Date: Wednesday, September 16, 2026

Location: Angel Stadium in Anaheim, CA

TV: FanDuel Sports Network West

Odds/Point Spread: Seattle (-152) Los Angeles (+126)

The Seattle Mariners (70-81) are en route to Angel Stadium on Wednesday where they will attempt to beat the Los Angeles Angels (57-93). The moneyline on this game has Seattle at -152 and Los Angeles is sitting at +126. The total has been set at 9. The pitchers who are expected to start will be George Kirby and Yusei Kikuchi.

The Mariners have compiled 187 doubles as a team and have knocked 175 balls out of the stadium. Seattle owns a slugging percentage of .380 and have been called out on strikes 1,312 times, while taking a walk on 512 occasions. As a unit, the Seattle Mariners are knocking in 4.1 runs per game, which is 28th in baseball. They have tallied 594 runs batted in as well as 1,165 base knocks over the course of the season, and their average at the plate sits at .232. They have racked up 616 runs and have an on-base percentage of .312.

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The Mariners have an earned run average of 4.24 for the season (20th in the league), and their staff has rung up 1,280 batters. Mariners pitchers have allowed 185 home runs and 676 runs (17th in MLB). Their pitching staff has walked 401 players from the other team and their FIP sits at 4.04 as a unit so far this year. Seattle has given up 1,272 base hits (8.6 per 9 innings) and also 627 earned runs. They have a K/BB ratio of 3.19 and their pitching staff holds a collective WHIP of 1.26.

The Mariners relievers have a save percentage of 55.9% and stepped onto the hill in 137 save situations. They have recorded 33 saves for the season and have blown 26 out of their 59 save chances. The relievers have inherited 157 base runners for the year with 32.5% of those players ended up crossing the plate. Mariners bullpen pitchers have entered the game with runners on 113 times and also have had 150 appearances in high leverage situations. The Mariners have sent 464 relievers to the hill on the season. The bullpen are sitting with 77 holds on the year (19th in baseball).

The Seattle Mariners have accounted for 3,997 putouts on the year, as well as 1,248 assists and 78 errors. Their fielding rate is at .985 which puts them in 16th in pro baseball, and have earned 119 double plays. The Mariners have turned 69.1% of balls hit into play into outs out of their 11,991 innings, ranking them 25th in professional baseball.

Kirby (54-45 career mark) has earned a FIP of 3.67 while he has gone up against 3,296 hitters in the majors. He has conceded 802 hits (9.0 hits per 9 innings) and has had 132 walks. His earned run average is 3.72 (332 earned runs allowed) and his career WHIP is 1.164. Kirby has taken the hill for 802 innings and has racked up 759 punch outs so far in his career.

The Los Angeles Angels are sitting with an on-base percentage of .308 as well as a team batting average of .234 so far this year. They have been called out on strikes on 1,423 occasions (2nd in baseball) and have accounted for 1,169 base hits. Los Angeles has knocked in 145 home runs over the course of the season to go along with 583 RBIs. The Angels have a team SLG% of .372 and they score 4.07 runs per outing (29th in MLB). They have hit 228 doubles, while walking 463 times as well as earning 610 runs.

The Angels have a WHIP of 1.342 with a FIP of 4.12 as a squad over the course of the season. They have earned a strikeout to walk ratio of 9.10 (1,340 strikeouts against 601 bases on balls). They rank 7th in MLB as a pitching staff in total hits allowed with 1,174. They have relinquished 154 dingers and they surrender 4.65 runs per 9 innings (20th in baseball). The Los Angeles pitching staff have given up 684 runs on the year while holding an ERA of 4.22 (620 earned runs relinquished).

Sitting with 139 save situations, the Angels have 85 holds and 28 blown saves. Los Angeles has called on relievers to enter the contest in 51 save opportunities and they have come away with 23 saves. Los Angeles relief pitchers have an inherited score percentage of 38.8% out of their 224 inherited base runners. Their relievers have taken the field 157 times in high leverage situations in addition to 148 occasions with base runners. They sit at 30th in MLB holding a save rate of 45.1%, and they have sent 480 relief pitchers to the hill on the campaign.

The Los Angeles Angels have gotten 100 double plays and hold a fielding percentage of .985 (19th in professional baseball). The Angels have racked up 1,253 assists, 82 errors and have accumulated 3,970 putouts this year. In 11,910 innings played, the Angels have a defensive efficiency of 69.8% (14th in professional baseball).

In his career, Kikuchi has given up 1,042 base knocks while accumulating 1,065 punch outs in 1,041 frames. He has surrendered a total of 518 ER's while earning a WHIP of 1.365 and a FIP of 4.4. He has a K/BB ratio of 2.81 and he has faced 4,479 batters in his pro baseball career. Kikuchi (49-63 career record) has earned a 4.48 earned run average while giving up 9.0 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Los Angeles (+126)

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