Seattle Mariners vs San Diego Padres Prediction, 4/16/2026 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs San Diego Padres

Date: Thursday, April 16, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Seattle (+162) San Diego (-196)

Petco Park is where the San Diego Padres (11-6) will take on the Seattle Mariners (8-10) on Thursday. The moneyline on this matchup has Seattle at +162 and San Diego is coming in at -196. The betting total is set at 8. The starting pitchers will be Luis Castillo and Walker Buehler.

The Mariners have hit 20 doubles as a team and have smacked 16 balls out of the stadium. Seattle has a slugging percentage of .332 and have been called out on strikes 168 times, while drawing a walk on 79 occasions. As a squad, the Seattle Mariners are putting up 3.9 runs per game, which ranks them 24th in the league. They have accumulated 67 RBI's and 119 hits for the season, and their average at the plate is .205. They have a total of 70 runs while having a team on-base percentage of .313.

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They have a K/BB ratio of 4.00 and their pitching staff has earned a collective WHIP of 1.07. Mariners pitchers have surrendered 11 long balls and 62 runs in total (7th in baseball). Seattle has allowed 133 base hits (7.5 per 9 innings) and 54 earned runs. The Mariners hold a team earned run average of 3.02 this season (2nd in MLB), and they have rung up 152 batters. They have walked 38 players from the other team and their FIP comes in at 3.01 as a unit so far this year.

The Mariners bullpen have accumulated a save percentage of 60.0% and have stepped onto the mound in 9 save situations. They have compiled 3 saves so far this season and have blown 2 out of their 5 chances to get a save. The relief pitchers have inherited 14 runners this season and 21.4% of those runners ended up crossing the plate. Mariners pitchers have stepped onto the hill with opponents on base 13 times in addition to having 18 appearances in high leverage situations. The Mariners have sent 48 relief pitchers to the hill on the year. The relievers have a total of 4 holds over the course of the season (28th in MLB).

The Mariners have turned 70.1% of baseballs in play into outs out of 1,446 innings on the diamond, which ranks them 14th in MLB. The San Francisco Giants are sitting with 482 putouts at this point in the season, as well as 151 assists and 8 errors. Their fielding percentage is currently at .988 which puts them in 9th in the majors, and they have turned 25 double plays.

Castillo has taken the hill for 1,423 innings and has earned 1,507 punch outs during his career. His ERA is 3.59 (567 earned runs allowed) and his WHIP is 1.183. He has allowed 1,227 base hits (7.8 hits per nine innings) and has 457 walks. Castillo (84-84 mark in his career) has earned a FIP of 3.53 while he has gone up against 5,886 batters in the majors.

San Diego has accounted for 16 home runs so far this year to go along with 73 RBIs. They have notched 35 two-baggers, while walking 61 times and putting up 78 runs. The San Diego Padres have a team OBP of .310 in addition to a batting average of .233 this season. The Padres have a team slugging % of .388 and they average 4.59 runs per game (12th in the league). They have been called out on strikes on 124 occasions (28th in baseball) and have totaled 131 base hits.

The Padres hold a team WHIP of 1.188 and are the owners of a FIP of 3.12 as a unit on the campaign. Their K/BB ratio comes in at 9.20 (158 strikeouts against 53 walks). They are currently ranked 10th in the league as a staff in total hits conceded with 130. They have surrendered 10 home runs and they yield 3.56 runs per 9 innings (5th in MLB). The San Diego pitching staff have surrendered 61 runs on the year while holding an ERA of 3.27 (56 earned runs conceded).

With 21 save situations, the Padres have earned 9 holds and 5 blown saves. San Diego has called on relief pitchers to step onto the mound in 10 save chances and they have earned 5 saves. San Diego bullpen pitchers have an inherited score percentage of 50.0% out of their 24 inherited base runners. Their relief pitchers have stepped onto the mound 17 times in high leverage situations in addition to 15 occasions with base runners. They are ranked 25th in the league with a save percentage of 50.0%, and they have sent 56 relievers to the hill over the course of the season.

The San Diego Padres have turned 18 double plays and have earned a fielding percentage of .990 (5th in pro baseball). The Padres have racked up 150 assists, 6 errors and have a total of 462 putouts so far this season. Out of their 1,386 innings on the field, the Padres hold a defensive efficiency of 69.3% (21st in baseball).

During his career, Buehler has surrendered 729 base hits while earning 857 K's in 851 innings. Buehler (57-30 career win-loss record) has a 3.54 ERA and has conceded 7.7 hits per 9 innings. He has conceded 335 ER's while earning a WHIP of 1.157 and a FIP of 3.5. He has a strikeout to walk ratio of 3.35 and he has faced 3,520 opposing hitters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take San Diego (-196)

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