Seattle Mariners vs St. Louis Cardinals Prediction, 4/26/2026 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs St. Louis Cardinals

Date: Sunday, April 26, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Seattle (-160) St. Louis (+132)

The Seattle Mariners (11-15) are hitting the road to Busch Stadium on Sunday where they will take on the St. Louis Cardinals (14-10). The moneyline on this contest has the Mariners at -160 and the Cardinals open at +132. The total is 8. The pitchers taking the mound will be Emerson Hancock and Michael McGreevy.

The Mariners have recorded 36 doubles as a unit and have smacked 25 balls out of the stadium. Seattle owns a slugging percentage of .363 and have been called out on strikes 236 times, while drawing a walk on 105 occasions. As a squad, the Seattle Mariners are earning 3.9 runs per game, which has them sitting at 25th in the league. They have tallied 98 RBI's as well as 193 hits on the campaign, and their average at the plate is sitting at .226. They have notched a total of 101 runs scored while holding a team on-base percentage of .320.

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They have a K/BB ratio of 3.44 and the pitching staff has earned a collective WHIP of 1.22. Mariners pitchers have surrendered 20 long balls in addition to 99 runs in total (8th in MLB). Seattle has conceded 219 hits (8.5 per 9 innings) in addition to 88 earned runs. The Mariners are sitting with a team earned run average of 3.42 on the year (4th in baseball), and their staff has rung up 217 batters. Their pitching staff has walked 63 batters and their FIP is 3.39 as a team on the campaign.

The Mariners have sent 79 relief pitchers to the hill for the season. The relief pitchers have inherited 29 base runners on the campaign with 17.2% of those players crossing the plate. The relief pitchers have racked up 11 holds so far this season (25th in the league). Mariners bullpen pitchers have stepped onto the hill with runners on 22 times as well as having 25 appearances in high leverage situations. They have recorded 5 saves this year and have blown 4 of their 9 save opportunities. The Mariners relievers have recorded a save percentage of 55.6% and have entered the game in 20 save situations.

The Mariners have turned 68.0% of balls in play into outs out of their 2,082 innings on the diamond, which has them ranked 26th in the majors. The Seattle Mariners have accumulated 694 putouts this season, as well as 226 assists and 11 errors. Their fielding percentage sits at .988 which is 7th in MLB, and have accumulated 31 double plays.

Hancock has thrown 190 innings and is sitting with 137 strikeouts so far in his career. Hancock (10-10 win-loss record in his career) is the owner of a FIP of 4.47 while facing 805 opposing batters in the majors. His ERA is 4.54 (96 earned runs allowed) and he has a WHIP of 1.292. He has surrendered 189 base knocks (8.9 hits per 9 innings) and has 57 free passes.

The St. Louis Cardinals have recorded a team OBP of .321 and a team batting average of .229 this season. They have been called out on strikes on 208 instances (17th in MLB) and have accounted for 183 hits. St. Louis has hit 27 home runs so far this season to go along with 109 runs batted in. The Cardinals hold a slugging percentage of .375 and they earn 4.67 runs per outing (12th in baseball). They have hit 33 two-baggers, while getting a free base 95 times as well as scoring 112 runs.

The St. Louis pitching staff have allowed 123 runs for the year while having an ERA of 4.77 (115 earned runs relinquished). They have allowed 26 dingers and they give up 5.10 runs per 9 innings (25th in the league). The Cardinals hold a team WHIP of 1.429 and have a FIP of 4.80 as a squad this year. They currently have a strikeout to walk ratio of 6.40 (154 strikeouts against 97 free passes). They rank 22nd in the league as a staff in total hits relinquished with 213.

St. Louis bullpen pitchers have an inherited score percentage of 36.6% out of 41 inherited runners. Their relievers have come in 31 times in high leverage situations in addition to 28 occasions with base runners. Sitting with 33 save situations, the Cardinals have earned 20 holds and also 3 blown saves. They are ranked 7th in baseball holding a save rate of 75.0%, and they have sent 89 relief pitchers onto the field for the year.

In 1,953 innings on the diamond, the Cardinals have earned a defensive efficiency of 70.4% (12th in the majors). The St. Louis Cardinals have turned 18 double plays and hold a fielding percentage of .985 (17th in professional baseball). The Cardinals have accrued 244 assists, 14 errors and have notched a total of 651 putouts for the year.

During his career, McGreevy has given up 136 base hits while accumulating 91 strikeouts in 145 innings pitched. McGreevy (12-6 mark in his career) has a 3.84 earned run average while surrendering 8.4 hits per nine innings. He has allowed a total of 62 ER's while earning a WHIP of 1.122 and a FIP of 3.8. He has a K/BB ratio of 3.37 and he has faced 591 batters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take St. Louis (+132)

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