St. Louis Cardinals vs Cincinnati Reds Prediction, 5/23/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Cincinnati Reds

Date: Saturday, May 23, 2026

Location: Great American Ball Park in Cincinnati, OH

TV: Reds.TV

Odds/Point Spread: St. Louis (+162) Cincinnati (-196)

The St. Louis Cardinals (28-21) are traveling to Great American Ball Park on Saturday where they will play the Cincinnati Reds (26-24). The moneyline on this matchup has the Cardinals at +162 while the Reds are coming in at -196. The betting total is set at 8. The pitchers taking the mound will be Andre Pallante and Brady Singer.

St. Louis is slugging .389 and have been called out on strikes 399 times, while taking a walk on 166 occasions. They have 212 runs batted in and 395 base knocks over the course of the season, while their batting average sits at .240. The Cardinals have compiled 72 doubles as a squad and have smacked 56 balls out of the park. They are sitting with 219 runs while holding a team on-base percentage of .320. As a unit, the St. Louis Cardinals are knocking in 4.5 runs per contest, which has them at 12th in baseball.

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The Cardinals hold a team earned run average of 4.24 this season (19th in the league), and their staff has rung up 358 hitters. Cardinals pitchers have conceded 52 long balls and 224 runs in total (18th in the league). They have walked 182 opposing hitters and their FIP sits at 4.41 as a team so far this season. St. Louis has surrendered 432 hits (8.8 per 9 innings) and also 209 earned runs. They have a K/BB ratio of 1.97 and the pitching staff has earned a collective WHIP of 1.39.

The Cardinals have dispatched 177 relief pitchers to the hill on the campaign. The relievers have inherited 78 runners for the year and 33.3% of those runners crossing home plate. The bullpen have a total of 43 holds this season (2nd in the league). Cardinals bullpen pitchers have stepped onto the hill with runners on base 56 times as well as having 63 appearances in high leverage situations. They have earned 17 saves this season and have missed out on 9 out of their 26 chances to get a save. The Cardinals bullpen have earned a save rate of 65.4% and have stepped onto the mound in 71 save situations.

The Cardinals have converted 69.5% of baseballs in play into outs out of their 3,990 innings on the field, which has them sitting 21st in MLB. The St. Louis Cardinals have notched a total of 1,330 putouts for the season, in addition to 478 assists and 23 errors. Their fielding percentage is at .987 which has them ranked 11th in MLB, and have accumulated 51 double plays.

Pallante has thrown 509 frames and has earned 361 punch outs in his MLB career. His earned run average is 4.30 (243 ER's allowed) and his WHIP is 1.411. He has given up 519 hits (9.2 hits per nine innings) with 199 walks. Pallante (28-33 career mark) sits with a FIP of 4.23 and he has faced 2,196 hitters in the major leagues.

The Cincinnati Reds are sitting with an on-base percentage of .312 and a team batting average of .229 on the campaign. They have been rung up on 453 instances (8th in the league) and have 384 hits. Cincinnati has hit 63 HRs this year as well as 208 RBIs. The Reds hold a team SLG% of .394 and they average 4.42 runs per game (14th in the league). They have hit 78 doubles, while getting a free base 192 times and putting up 221 runs.

The Reds have a WHIP of 1.458 in addition to having a FIP of 5.04 as a pitching staff on the year. They rank 22nd in MLB as a pitching staff in total hits allowed with 418. The Cincinnati pitching staff have relinquished 249 runs on the year and come in with a team ERA of 4.71 (233 earned runs surrendered). They currently have a strikeout to walk ratio of 7.90 (389 strikeouts vs 231 bases on balls). They have surrendered 68 homers and they relinquish 5.03 runs per 9 innings (25th in MLB).

Cincinnati bullpen pitchers hold an inherited score rate of 30.7% of 75 inherited base runners. Their bullpen pitchers have come in 62 times in high leverage situations and on 54 occasions with base runners. With 60 save situations, the Reds have accrued 37 holds in addition to 9 blown saves. They rank 20th in MLB with a save rate of 59.1%, and they have sent 187 relievers onto the field this year.

The Cincinnati Reds have gotten 46 double plays and have a fielding percentage of .988 (10th in professional baseball). The Reds have recorded 422 assists, 22 errors and have accounted for 1,336 putouts on the season. In their 4,008 innings on the diamond, the Reds have earned a efficiency on defense of 70.9% (10th in professional baseball).

In his pro baseball career, Singer has conceded 911 hits and he has 842 punch outs in 901 innings pitched. He has allowed 434 ER's while holding a WHIP of 1.329 and a FIP of 4.3. He has a strikeout to walk ratio of 2.94 and he has gone up against 3,866 opposing batters so far in his MLB career. Singer (52-60 career win-loss mark) holds a 4.34 ERA while allowing 9.1 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+162)

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