St. Louis Cardinals vs Cincinnati Reds Prediction, 5/24/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Cincinnati Reds

Date: Sunday, May 24, 2026

Location: Great American Ball Park in Cincinnati, OH

TV: Reds.TV

Odds/Point Spread: St. Louis (+132) Cincinnati (-160)

The Cincinnati Reds (26-24) will take on the St. Louis Cardinals (28-21) at Great American Ball Park on Sunday. The odds on this game have the Cardinals at +132 and the Reds are priced at -160. The over/under comes in at 9. The starting pitchers will be Matthew Liberatore and Nick Lodolo.

As a unit, the St. Louis Cardinals are scoring 4.5 runs per contest, which has them at 12th in the league. They have racked up 219 runs while holding a team on-base percentage of .320. The Cardinals have tallied 72 doubles as a unit and have smacked 56 balls out of the park. They have tallied 212 RBI's and 395 hits for the year, and their average at the plate sits at .240. St. Louis is slugging .389 and have been called out on strikes 399 times, while being walked on 166 occasions.

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The Cardinals have compiled a team earned run average of 4.24 on the year (19th in the league), and the staff has rung up 358 batters. Cardinals pitchers have surrendered 52 home runs and also 224 runs in total (18th in baseball). Their pitching staff has walked 182 opposing batters and their FIP is 4.41 as a unit for the season. St. Louis has given up 432 base hits (8.8 per 9 innings) in addition to 209 earned runs. Their strikeout to walk ratio sits at 1.97 and their pitching staff holds a collective WHIP of 1.39.

Cardinals relief pitchers have gone to the mound with runners on base 56 times as well as having 63 appearances in high leverage situations. The relievers have notched 43 holds for the season (2nd in MLB). The Cardinals relief pitchers have a save percentage of 65.4% and have stepped onto the mound in 71 save situations. They have 17 saves so far this year and have missed out on 9 of 26 save opportunities. The bullpen pitchers have inherited 78 runners on the season and 33.3% of them crossing the plate. The Cardinals have sent 177 relief pitchers to the hill so far this year.

The St. Louis Cardinals are sitting with 1,330 putouts for the season, as well as 478 assists and 23 errors. Their fielding percentage is at .987 which has them ranked 11th in MLB, and have 51 double plays. The Cardinals have converted 69.5% of baseballs in play into outs in their 3,990 innings on the diamond, which ranks them 21st in professional baseball.

Liberatore has taken the ball for 385 innings and has racked up 315 K's so far in his career. His ERA is 4.65 (199 earned runs allowed) and he has a WHIP of 1.397. He has allowed 407 hits (9.5 hits per nine innings) and has had 131 walks. Liberatore (18-26 career mark) sits with a FIP of 4.58 and he has gone up against 1,668 hitters in the majors.

The Cincinnati Reds have recorded an on-base percentage of .312 and a batting average of .229 on the year. They have been called out on strikes on 453 occasions (8th in baseball) and have 384 base knocks. Cincinnati has compiled 63 home runs so far this year as well as 208 RBIs. The Reds have a team slugging % of .394 and they are earning 4.42 runs per contest (14th in MLB). They have recorded 78 two-baggers, while getting a free base 192 times and earning 221 runs.

The Cincinnati pitching staff have allowed 249 runs so far this season while holding an ERA of 4.71 (233 earned runs surrendered). They have allowed 68 long balls and they concede 5.03 runs per 9 innings (25th in the league). The Reds have a WHIP of 1.458 in addition to having a FIP of 5.04 as a pitching staff on the campaign. They currently have a strikeout to walk ratio of 7.90 (389 strikeouts against 231 walks). They rank 22nd in baseball as a staff in total hits relinquished with 418.

They sit at 20th in MLB holding a save percentage of 59.1%, and they have sent 187 relievers onto the diamond on the campaign. Their relief pitchers have stepped onto the mound 62 times in high leverage situations and also on 54 occasions with base runners. With 60 save situations, the Reds have earned 37 holds in addition to 9 blown saves. Cincinnati has had relievers enter the game in 22 save chances and they have come away with 13 saves. Cincinnati relievers have an inherited score percentage of 30.7% out of 75 inherited runners.

The Cincinnati Reds have gotten 46 double plays and have a fielding percentage of .988 (10th in professional baseball). The Reds have recorded 422 assists, 22 errors and have notched a total of 1,336 putouts for the season. In 4,008 innings on the field, the Reds hold a defensive efficiency of 70.9% (10th in the majors).

In his pro baseball career, Lodolo has given up 393 hits while he has accumulated 467 K's in 424 innings pitched. Lodolo (24-23 win-loss mark in his career) holds a 4.18 earned run average and has surrendered 8.3 hits per nine innings. He has allowed 197 ER's while holding a WHIP of 1.223 and a FIP of 4.1. He has a strikeout to walk ratio of 3.71 and he has faced 1,809 batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (-160)

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