St. Louis Cardinals vs Milwaukee Brewers Prediction, 5/25/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Milwaukee Brewers

Date: Monday, May 25, 2026

Location: American Family Field in Milwaukee, WI

TV: Brewers.TV

Odds/Point Spread: St. Louis (+110) Milwaukee (-130)

The St. Louis Cardinals (29-22) are hitting the road to American Family Field on Monday where they will compete against the Milwaukee Brewers (30-19). The moneyline on this contest has St. Louis at +110 and Milwaukee is sitting at -130. The over/under has been set at 9. The starting pitchers are Matthew Liberatore and Jacob Misiorowski.

As a team, the St. Louis Cardinals are earning 4.6 runs per game, which has them at 10th in baseball. They have earned a total of 233 runs scored while holding a team on-base percentage of .323. The Cardinals have accounted for 74 two-baggers as a team and have knocked 60 balls out of the stadium. They have 226 RBI's as well as 416 base knocks on the campaign, and their team batting average comes in at .242. St. Louis has a slugging rate of .393 and have struck out 412 times, while taking a walk on 179 occasions.

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They have a K/BB ratio of 2.00 and their pitching staff has a collective WHIP of 1.37. Cardinals pitchers have given up 55 home runs in addition to 232 runs in total (17th in the league). St. Louis has relinquished 444 hits (8.6 per 9 innings) in addition to 216 earned runs. The Cardinals have an ERA of 4.20 on the season (20th in baseball), and the staff has rung up 380 batters. They have walked 190 opposing players and their FIP sits at 4.39 as a team this season.

The Cardinals relief pitchers have a save percentage of 65.4% and have come into the game in 71 save situations. They have earned 17 saves on the year and have blown 9 of their 26 save opportunities. The relievers have inherited 81 runners for the season and 32.1% of those runners crossing the plate. Cardinals relief pitchers have come into the game with players on base 58 times and also have had 65 appearances in high leverage situations. The Cardinals have dispatched 185 relievers to the mound on the year. The bullpen have a total of 43 holds for the season (2nd in MLB).

The St. Louis Cardinals have 1,388 putouts this year, in addition to 496 assists and 23 errors. Their fielding rate is holding steady at .988 which is 9th in the majors, and have a total of 52 double plays. The Cardinals have transformed 69.8% of balls in play into outs out of their 4,164 innings on the field, which has them sitting at 19th in pro baseball.

Liberatore has thrown 385 innings and is sitting with 315 punch outs in his MLB career. His ERA is 4.65 (199 earned runs allowed) and he has a WHIP of 1.397. He has conceded 407 base knocks (9.5 hits per 9 innings) and has 131 walks. Liberatore (18-26 career record) has a FIP of 4.58 and he has faced 1,668 hitters in the majors.

The Brewers hold a slugging % of .364 and they have an average of 5.00 runs per contest (4th in baseball). They have hit 82 doubles, while walking 212 times and notching 245 runs. Milwaukee has hit 34 long balls on the year and 230 runs batted in. They have been rung up on 386 occasions (28th in the league) and have 406 hits. The Milwaukee Brewers are sitting with a team on-base percentage of .334 in addition to a batting average of .246 on the campaign.

The Brewers have a team WHIP of 1.211 and have a FIP of 3.31 as a unit this year. They are sitting at 1st in the league as a staff in total hits surrendered with 352. The Milwaukee pitching staff have relinquished 174 runs for the year while holding an ERA of 3.28 (159 earned runs relinquished). They currently have a strikeout to walk ratio of 9.80 (476 strikeouts against 176 walks). They have yielded 36 home runs and they relinquish 3.59 runs per 9 innings (3rd in the league).

They are currently ranked 13th in MLB holding a save rate of 66.7%, and they have dispatched 154 relievers to the hill this season. Their relief pitchers have stepped onto the mound 47 times in high leverage situations in addition to 42 occasions with runners on. With 52 save situations, the Brewers have recorded 27 holds in addition to 8 blown saves. Milwaukee has called on relievers to take the mound in 24 save opportunities and they have recorded 16 saves. Milwaukee relievers have an inherited score rate of 34.8% out of 66 inherited runners.

The Milwaukee Brewers have gotten 39 double plays and have a fielding percentage of .987 (14th in MLB). The Brewers have recorded 379 assists, 22 errors and have a tally of 1,309 putouts for the year. In 3,927 innings on the diamond, the Brewers hold a defensive efficiency of 70.1% (18th in baseball).

During his career, Misiorowski has surrendered 83 hits and he has 175 K's in 123 innings. He has surrendered 44 ER's while earning a WHIP of 1.073 and a FIP of 3.2. His strikeout to walk ratio is 3.57 and he has faced 497 hitters in his pro baseball career. Misiorowski (9-5 record in his career) has earned a 3.22 earned run average and has given up 6.1 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take St. Louis (+110)

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