St. Louis Cardinals vs Milwaukee Brewers Prediction, 5/27/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Milwaukee Brewers

Date: Wednesday, May 27, 2026

Location: American Family Field in Milwaukee, WI

TV: Brewers.TV

Odds/Point Spread: St. Louis (+106) Milwaukee (-128)

American Family Field is where the Milwaukee Brewers (31-20) will attempt to defeat the St. Louis Cardinals (29-23) on Wednesday. The odds on this game have St. Louis at +106 and Milwaukee is at -128. The total has been set at 8. The starting pitchers are Dustin May and Chad Patrick.

The Cardinals have earned 74 doubles as a team and have smacked 60 balls out of the stadium. St. Louis is slugging .387 and have been rung up 425 times, while drawing a walk on 180 occasions. As a squad, the St. Louis Cardinals are recording 4.5 runs per game, which has them at 11th in the league. They have recorded 227 runs batted in as well as 418 base knocks this season, while their average at the plate sits at .239. They have accumulated 234 runs while holding a team on-base percentage of .320.

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The Cardinals hold a team ERA of 4.23 on the campaign (22nd in the league), and their staff has struck out 392 hitters. Cardinals pitchers have yielded 56 home runs and also 237 total runs (19th in the league). Their pitching staff has walked 194 hitters and their FIP is 4.35 as a unit on the year. St. Louis has surrendered 455 hits (8.7 per 9 innings) as well as 221 earned runs. They have accrued a K/BB ratio of 2.02 and the pitching staff has a team WHIP of 1.38.

The Cardinals bullpen have earned a save percentage of 65.4% and have entered the game in 71 save situations. They have earned 17 saves on the campaign and have not converted 9 out of their 26 chances to save the game. The relievers have inherited 81 base runners on the season with 32.1% of those players earned a run for their team. Cardinals pitchers have entered the game with runners on 58 times and also have had 65 appearances in high leverage situations. The Cardinals have dispatched 186 relievers to the mound on the campaign. The relievers have earned 43 holds on the year (2nd in the league).

The Cardinals have converted 69.5% of baseballs in play into outs out of their 4,236 innings on the diamond, which has them sitting 23rd in pro baseball. The St. Louis Cardinals are sitting with 1,412 putouts this year, in addition to 503 assists and 24 errors. Their fielding percentage is holding steady at .988 which ranks 11th in the majors, and have earned 53 double plays.

May has pitched in 378 frames and has 339 K's during his MLB career. His ERA is 4.02 (169 earned runs allowed) and he has a career WHIP of 1.233. He has conceded 336 base knocks (8.0 hits per nine innings) with 130 walks. May (22-25 record in his career) has a FIP of 3.96 while he has faced 1,586 opposing batters during his time in the major leagues.

The Brewers have a SLG% of .364 and they are earning 4.92 runs per contest (4th in baseball). They have notched 84 doubles, while walking 217 times as well as putting up 251 runs. Milwaukee has a total of 35 long balls this season to go along with 236 runs batted in. They have struck out on 405 occasions (27th in baseball) and have a total of 424 base hits. The Milwaukee Brewers have accounted for a team on-base percentage of .334 as well as a team batting average of .248 for the season.

The Brewers have a WHIP of 1.194 and are the owners of a FIP of 3.26 as a squad for the year. They currently have a strikeout to walk ratio of 9.90 (501 strikeouts vs 183 free passes). They are currently ranked 1st in the league as a pitching staff in total hits given up with 359. They have yielded 37 long balls and they concede 3.57 runs per 9 innings (3rd in MLB). The Milwaukee pitching staff have given up 180 runs for the season while holding a team ERA of 3.25 (164 earned runs conceded).

They are ranked 12th in the league with a save percentage of 66.7%, and they have sent 157 bullpen pitchers onto the diamond for the year. Their bullpen pitchers have taken the field 48 times in high leverage situations and on 43 occasions with runners on base. Sitting with 52 save situations, the Brewers have tallied 27 holds in addition to 8 blown saves. Milwaukee has had relief pitchers step onto the hill in 24 save opportunities and they have come away with 16 saves. Milwaukee relievers have an inherited score percentage of 36.8% out of their 68 inherited runners.

The Milwaukee Brewers have turned 39 double plays and hold a fielding percentage of .987 (12th in pro baseball). The Brewers have 389 assists, 23 errors and have a tally of 1,363 putouts this year. In their 4,089 innings on the field, the Brewers have accumulated a defensive efficiency of 70.4% (15th in pro baseball).

So far in his MLB career, Patrick has allowed 145 hits and he has 156 punch outs in 160 frames. He has given up a total of 59 earned runs while holding a WHIP of 1.261 and being the owner of a FIP of 3.3. He has a strikeout to walk ratio of 2.74 and he has gone up against 668 batters in his career. Patrick (5-10 record in his career) holds a 3.31 earned run average while allowing 8.1 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take St. Louis (+106)

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