St. Louis Cardinals vs Milwaukee Brewers Prediction, 9/25/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Milwaukee Brewers

Date: Friday, September 25, 2026

Location: American Family Field in Milwaukee, WI

TV: Brewers.TV

Odds/Point Spread: St. Louis (+110) Milwaukee (-132)

American Family Field is the site where the Milwaukee Brewers (98-59) will go up against the St. Louis Cardinals (76-81) on Friday. The moneyline on this contest has St. Louis at +110 while Milwaukee opens at -132. The total is set at 8. The starting pitchers will be Michael McGreevy and Robert Gasser.

The Cardinals have recorded 226 two-baggers as a unit and have hit 161 balls out of the park. St. Louis has a slugging rate of .380 and have been called out on strikes 1,248 times, while taking a walk on 498 occasions. As a squad, the St. Louis Cardinals are putting up 4.5 runs per outing, which has them sitting at 13th in baseball. They have 681 RBI's and 1,278 hits on the season, and their batting average is sitting at .241. They have racked up 704 runs scored while holding a team on-base percentage of .314.

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They have accrued a K/BB ratio of 2.27 and the pitching staff holds a collective WHIP of 1.35. Cardinals pitchers have yielded 155 long balls and also 729 runs in total (22nd in baseball). St. Louis has given up 1,350 base hits (8.7 per 9 innings) and also 667 earned runs. The Cardinals hold a team earned run average of 4.28 for the season (21st in the league), and their staff has struck out 1,239 hitters. Their pitching staff has walked 547 opposing batters and their FIP sits at 4.10 as a squad over the course of the season.

Cardinals relief pitchers have entered the contest with players on base 164 times as well as having 195 appearances in high leverage situations. The bullpen have a total of 96 holds so far this season (8th in the league). The Cardinals relief pitchers have earned a save rate of 60.5% and stepped onto the hill in 176 save situations. They have accumulated 46 saves this year and have blown 30 of 76 save chances. The bullpen pitchers have inherited 239 base runners so far this season with 40.6% of them crossing home plate. The Cardinals have sent 534 relievers to the hill this year.

The St. Louis Cardinals have a tally of 4,205 putouts on the campaign, in addition to 1,473 assists and 74 errors. Their fielding rate is holding steady at .987 which is 9th in the majors, and they have turned 149 double plays. The Cardinals have turned 69.0% of baseballs in play into outs in their 12,615 innings on the diamond, ranking them 24th in baseball.

McGreevy (18-13 win-loss record in his career) has a FIP of 3.83 while he has gone up against 1,163 hitters during his time in the major leagues. He has allowed 275 base hits (8.8 hits per nine innings) with 68 walks. His ERA is 3.89 (122 earned runs allowed) and his career WHIP is 1.215. McGreevy has thrown 282 innings and has racked up 189 punch outs so far in his MLB career.

The Milwaukee Brewers have earned a team on-base percentage of .340 in addition to a team batting average of .258 this year. They have struck out on 1,338 occasions (11th in MLB) and have 1,375 hits. Milwaukee has compiled 149 home runs over the course of the season and 762 RBIs. The Brewers have a team slugging percentage of .402 and they score 5.13 runs per game (2nd in baseball). They have notched 270 two-baggers, while walking 650 times and racking up 806 runs.

The Brewers have a WHIP of 1.189 and are the owners of a FIP of 3.72 as a pitching staff so far this season. Their strikeout to walk ratio is 9.60 (1,496 strikeouts against 503 free passes). They come in at 2nd in the league as a pitching staff in total hits given up with 1,163. They have relinquished 166 long balls and they give up 3.89 runs per 9 innings (4th in the league). The Milwaukee pitching staff have surrendered 606 runs so far this year while having a team ERA of 3.55 (553 earned runs yielded).

With 155 save situations, the Brewers have earned 82 holds in addition to 20 blown saves. Milwaukee has called on relief pitchers to enter the contest in 71 save opportunities and they have converted 51 saves. Milwaukee relief pitchers have an inherited score rate of 37.8% out of 185 inherited base runners. Their relief pitchers have come in 155 times in high leverage situations and on 127 occasions with runners on base. They sit at 7th in baseball with a save percentage of 71.8%, and they have dispatched 492 relievers onto the diamond this season.

The Milwaukee Brewers have turned 117 double plays and have accounted for a fielding rate of .987 (8th in MLB). The Brewers have accrued 1,234 assists, 70 errors and have notched a total of 4,205 putouts during this campaign. Out of their 12,615 innings played, the Brewers have accumulated a efficiency on defense of 70.9% (8th in pro baseball).

Gasser (7-7 win-loss mark in his career) has earned a 3.70 ERA while surrendering 8.4 hits per nine innings. He has a strikeout to walk ratio of 2.95 and he has gone up against 586 batters during his MLB career. He has given up a total of 56 ER's while earning a WHIP of 1.218 and having a FIP of 3.6. So far in his MLB career, Gasser has given up 127 base hits while totaling 115 K's in 136 frames.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Milwaukee (-132)

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