St. Louis Cardinals vs Milwaukee Brewers Prediction, 9/26/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Milwaukee Brewers

Date: Saturday, September 26, 2026

Location: American Family Field in Milwaukee, WI

TV: Brewers.TV

Odds/Point Spread: St. Louis (+106) Milwaukee (-128)

The St. Louis Cardinals (77-82) are hitting the road to American Family Field on Saturday where they will compete against the Milwaukee Brewers (100-59). The line on this contest has St. Louis at +106 while Milwaukee is at -128. The betting total is set at 8. The pitchers expected to start will be Quinn Mathews and Dustin May.

As a team, the St. Louis Cardinals are scoring 4.5 runs per contest, which has them at 13th in the league. They are sitting with 710 runs while holding a team OBP of .314. The Cardinals have accounted for 228 doubles as a squad and have knocked 162 baseballs out of the stadium. They have amassed 686 RBI's in addition to 1,293 hits on the campaign, and their batting average sits at .241. St. Louis has a slugging rate of .379 and have been rung up 1,271 times, while being walked on 504 occasions.

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They have accrued a K/BB ratio of 2.27 and the pitching staff has a team WHIP of 1.35. Cardinals pitchers have conceded 156 long balls and also 732 runs in total (22nd in the league). St. Louis has given up 1,363 hits (8.6 per 9 innings) as well as 669 earned runs. The Cardinals have compiled a team earned run average of 4.24 so far this season (20th in MLB), and the staff has struck out 1,256 batters. Their pitching staff has walked 553 opposing batters and their FIP is 4.08 as a unit this year.

The Cardinals bullpen have a save rate of 60.5% and have come into the game in 176 save situations. They have earned 46 saves on the season and have blown 30 of 76 save opportunities. The relievers have inherited 241 runners this season with 40.2% of them crossing the plate. Cardinals relief pitchers have entered the contest with players on base 166 times in addition to having 198 appearances in high leverage situations. The Cardinals have dispatched 541 relief pitchers to the mound for the year. The bullpen have accumulated 96 holds on the campaign (8th in MLB).

The Cardinals have turned 69.0% of baseballs in play into outs out of their 12,768 innings, which ranks them 24th in the majors. The St. Louis Cardinals have 4,256 putouts this year, in addition to 1,490 assists and 76 errors. Their fielding percentage is holding steady at .987 which puts them in 10th in pro baseball, and have earned 150 double plays.

Mathews has taken the hill for 44 frames and has accounted for 39 punch outs so far in his career. Mathews (2-3 career record) holds a FIP of 3.62 while he has faced 190 opposing batters in the major leagues. His ERA is 3.67 (18 earned runs allowed) and his WHIP is 1.383. He has surrendered 43 hits (8.8 hits per 9 innings) with 18 walks.

The Brewers have a SLG% of .402 and they tally 5.13 runs per outing (2nd in the league). They have recorded 273 two-baggers, while taking a walk 657 times and putting up 815 runs. Milwaukee has accumulated 152 home runs on the season as well as 771 runs batted in. They have struck out on 1,361 instances (11th in the league) and have a total of 1,392 base hits. The Milwaukee Brewers have tallied a team OBP of .340 as well as a batting average of .258 for the season.

The Brewers have a WHIP of 1.187 and have a FIP of 3.71 as a unit over the course of the season. They come in at 2nd in baseball as a staff in total hits conceded with 1,173. The Milwaukee pitching staff have conceded 608 runs on the season while having a team ERA of 3.52 (555 earned runs conceded). Their K/BB ratio comes in at 9.60 (1,509 strikeouts against 511 free passes). They have surrendered 166 home runs and they surrender 3.86 runs per 9 innings (4th in the league).

With 159 save situations, the Brewers have amassed 84 holds in addition to 20 blown saves. Milwaukee has called on bullpen pitchers to enter the contest in 73 save chances and they have tallied 53 saves. Milwaukee relief pitchers hold an inherited score percentage of 37.6% out of their 186 inherited base runners. Their relief pitchers have taken the field 156 times in high leverage situations and on 128 occasions with runners on. They are ranked 6th in the league with a save percentage of 72.6%, and they have dispatched 499 relief pitchers onto the field on the campaign.

In their 12,777 innings on the diamond, the Brewers have accumulated a defensive efficiency of 71.1% (8th in baseball). The Milwaukee Brewers have turned 117 double plays and have a fielding rate of .987 (7th in pro baseball). The Brewers have accrued 1,254 assists, 71 errors and have 4,259 putouts this season.

In his MLB career, May has allowed 310 base hits while he has earned 330 K's in 357 innings. May (21-22 career record) is the owner of a 4.03 earned run average while conceding 7.8 hits per 9 innings. He has given up a total of 160 earned runs while holding a WHIP of 1.223 and a FIP of 4.0. He has a K/BB ratio of 2.60 and he has faced 1,505 hitters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+106)

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