St. Louis Cardinals vs Milwaukee Brewers Prediction, 9/27/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Milwaukee Brewers

Date: Sunday, September 27, 2026

Location: American Family Field in Milwaukee, WI

TV: Brewers.TV

Odds/Point Spread: St. Louis (+126) Milwaukee (-152)

The Milwaukee Brewers (100-59) will compete against the St. Louis Cardinals (77-82) at American Family Field on Sunday. The line on this matchup has the Cardinals at +126 while the Brewers are coming in at -152. The total has been set at 8.5. The pitchers taking the mound are Andre Pallante and Kyle Harrison.

St. Louis has a slugging % of .379 and have been called out on strikes 1,271 times, while taking a walk on 504 occasions. They have earned 686 RBI's in addition to 1,293 hits on the season, while their batting average is at .241. The Cardinals have compiled 228 two-baggers as a squad and have hit 162 balls out of the stadium. They have accounted for 710 runs while holding a team OBP of .314. As a team, the St. Louis Cardinals are knocking in 4.5 runs per game, which has them sitting at 13th in the league.

Get all of our MLB Expert Picks

They have a strikeout to walk ratio of 2.27 and their pitching staff has recorded a WHIP of 1.35. Cardinals pitchers have allowed 156 home runs in addition to 732 runs (22nd in MLB). St. Louis has surrendered 1,363 base hits (8.6 per 9 innings) and also 669 earned runs. The Cardinals have an ERA of 4.24 this season (20th in MLB), and the staff has struck out 1,256 batters. They have walked 553 opposing players and their FIP sits at 4.08 as a squad so far this season.

The Cardinals relievers have accumulated a save rate of 60.5% and have stepped onto the mound in 176 save situations. They have 46 saves so far this season and have blown 30 out of their 76 chances to save the game. The relief pitchers have inherited 241 runners for the season and 40.2% of them ended up crossing the plate. Cardinals pitchers have come into the game with runners on base 166 times in addition to having 198 appearances in high leverage situations. The Cardinals have sent 541 relievers to the hill on the year. The relief pitchers have a total of 96 holds so far this season (8th in MLB).

The St. Louis Cardinals have accounted for 4,256 putouts at this point in the season, as well as 1,490 assists and 76 errors. Their fielding percentage is holding steady at .987 which is 10th in baseball, and have a total of 150 double plays. The Cardinals have turned 69.0% of balls in play into outs out of 12,768 innings, which has them sitting 24th in the majors.

Pallante has taken the mound for 617 innings and has earned 427 strikeouts during his MLB career. Pallante (36-37 record in his career) has earned a FIP of 4.08 while facing 2,637 hitters in the major leagues. His earned run average is 4.14 (284 earned runs allowed) and his WHIP is 1.373. He has conceded 618 hits (9.0 hits per nine innings) with 229 walks.

The Milwaukee Brewers have a team on-base percentage of .340 as well as a batting average of .258 over the course of the season. They have struck out on 1,361 occasions (11th in MLB) and have 1,392 base knocks. Milwaukee is sitting with 152 HRs for the season to go along with 771 RBIs. The Brewers hold a team slugging percentage of .402 and they average 5.13 runs per game (2nd in the league). They have hit 273 doubles, while walking 657 times and recording 815 runs.

The Brewers are sitting with a team WHIP of 1.187 with a FIP of 3.71 as a squad on the campaign. Their strikeout to walk ratio comes in at 9.60 (1,509 strikeouts vs 511 walks). They are sitting at 2nd in the league as a pitching staff in total hits conceded with 1,173. They have allowed 166 long balls and they relinquish 3.86 runs per 9 innings (4th in baseball). The Milwaukee pitching staff have allowed 608 runs this season while having an ERA of 3.52 (555 earned runs given up).

Milwaukee bullpen pitchers have an inherited score percentage of 37.6% out of their 186 inherited base runners. Their relief pitchers have taken the field 156 times in high leverage situations and on 128 occasions with runners on. With 159 save situations, the Brewers have accumulated 84 holds in addition to 20 blown saves. They rank 6th in MLB with a save rate of 72.6%, and they have dispatched 499 relievers to the mound so far this year.

In 12,777 innings played, the Brewers hold a efficiency on defense of 71.1% (8th in pro baseball). The Milwaukee Brewers have turned 117 double plays and own a fielding percentage of .987 (7th in baseball). The Brewers have 1,254 assists, 71 errors and have a tally of 4,259 putouts this season.

Harrison (19-14 mark in his career) has a 4.36 earned run average and has surrendered 9.0 hits per nine innings. He has a K/BB ratio of 3.18 and he has gone up against 1,333 batters in his MLB career. He has conceded a total of 149 earned runs while earning a WHIP of 1.340 and a FIP of 4.3. So far in his career, Harrison has allowed 309 base knocks while earning 328 punch outs in 307 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Milwaukee (-152)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.