St. Louis Cardinals vs Pittsburgh Pirates Prediction, 4/27/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Pittsburgh Pirates

Date: Monday, April 27, 2026

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: St. Louis (+110) Pittsburgh (-130)

The St. Louis Cardinals (14-12) are traveling to PNC Park on Monday where they will go up against the Pittsburgh Pirates (16-11). The moneyline on this game has St. Louis at +110 and Pittsburgh is opening at -130. The betting total is set at 8.5. The pitchers taking the mound will be Dustin May and Bubba Chandler.

As a unit, the St. Louis Cardinals are earning 4.7 runs per game, which has them sitting at 11th in the league. They have tallied 123 runs scored and have an OBP of .325. The Cardinals have accounted for 34 two-baggers as a team and have knocked 32 baseballs out of the stadium. They have recorded 120 runs batted in and 205 hits for the year, while their team batting average is .236. St. Louis is slugging .388 and have been called out on strikes 220 times, while taking a walk on 98 occasions.

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The Cardinals have an earned run average of 4.94 over the course of the season (27th in baseball), and their staff has struck out 170 hitters. Cardinals pitchers have relinquished 30 home runs and also 137 runs in total (26th in MLB). They have walked 105 opposing batters and their FIP sits at 4.89 as a team on the campaign. St. Louis has given up 236 hits (9.0 per 9 innings) in addition to 129 earned runs. Their strikeout to walk ratio sits at 1.62 and their pitching staff has earned a collective WHIP of 1.45.

The Cardinals have dispatched 99 relievers to the hill over the course of the season. The bullpen pitchers have inherited 48 base runners on the campaign and 37.5% of those players ended up scoring. The relievers have earned 21 holds on the season (3rd in baseball). Cardinals bullpen pitchers have stepped onto the hill with runners on 33 times in addition to having 35 appearances in high leverage situations. They have compiled 9 saves on the year and have not converted 5 of 14 save opportunities. The Cardinals bullpen have accumulated a save rate of 64.3% and have entered the game in 36 save situations.

The St. Louis Cardinals have amassed 705 putouts at this point in the season, as well as 262 assists and 14 errors. Their fielding percentage is at .986 which has them sitting 15th in the majors, and they have turned 20 double plays. The Cardinals have turned 70.0% of balls hit into play into outs out of their 2,115 innings on the field, which has them sitting 14th in pro baseball.

May has thrown 348 innings and is sitting with 317 punch outs in his MLB career. May (22-22 career record) sits with a FIP of 3.95 while facing 1,462 batters in the major leagues. His ERA is 4.01 (155 earned runs allowed) and his career WHIP is 1.226. He has surrendered 309 hits (8.0 hits per 9 innings) and has 118 free passes.

The Pirates hold a slugging % of .380 and they are scoring 5.00 runs per contest (7th in the league). They have put up 35 doubles, while walking 104 times and scoring 135 runs. Pittsburgh has compiled 29 home runs for the year as well as 130 RBIs. They have struck out on 253 occasions (4th in baseball) and have 232 hits. The Pittsburgh Pirates have recorded a team OBP of .330 and a batting average of .246 for the season.

The Pirates have a WHIP of 1.241 in addition to having a FIP of 3.56 as a team so far this season. They sit at 5th in MLB as a pitching staff in total hits relinquished with 200. The Pittsburgh pitching staff have surrendered 106 runs this season while holding a team ERA of 3.30 (91 earned runs relinquished). They have earned a K/BB ratio of 9.20 (254 strikeouts against 108 bases on balls). They have surrendered 19 homers and they yield 3.85 runs per 9 innings (5th in MLB).

Pittsburgh relievers have an inherited score rate of 30.8% out of 26 inherited runners. Their relief pitchers have stepped onto the mound 39 times in high leverage situations and also on 24 occasions with base runners. Sitting with 32 save situations, the Pirates have tallied 20 holds in addition to 7 blown saves. They are ranked 27th in the league with a save rate of 41.7%, and they have sent 95 bullpen pitchers onto the diamond for the year.

In 2,235 innings on the diamond, the Pirates have accumulated a efficiency on defense of 70.8% (11th in the majors). The Pittsburgh Pirates have turned 19 double plays and hold a fielding percentage of .985 (18th in MLB). The Pirates have recorded 217 assists, 15 errors and have a tally of 745 putouts over the course of the season.

Chandler (5-3 career mark) holds a 4.41 ERA while surrendering 7.4 hits per nine innings. His strikeout to walk ratio is 2.60 and he has faced 232 opposing hitters in his pro baseball career. He has given up a total of 27 earned runs while holding a WHIP of 1.180 and having a FIP of 4.3. In his career, Chandler has conceded 45 base knocks while accumulating 52 K's in 55 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Pittsburgh (-130)

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