St. Louis Cardinals vs Pittsburgh Pirates Prediction, 4/29/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Pittsburgh Pirates

Date: Wednesday, April 29, 2026

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: St. Louis (+120) Pittsburgh (-144)

The Pittsburgh Pirates (16-13) will play the St. Louis Cardinals (15-13) at PNC Park on Wednesday. The moneyline on this game has St. Louis at +120 and Pittsburgh is at -144. The total has been set at 8. The pitchers who are expected to start are Andre Pallante and Bubba Chandler.

St. Louis has a slugging percentage of .390 and have struck out 232 times, while being walked on 103 occasions. They have compiled 126 runs batted in as well as 218 base knocks so far this year, and their batting average sits at .234. The Cardinals have hit 36 doubles as a team and have hit 36 balls out of the park. They have tallied 129 runs and have an OBP of .321. As a team, the St. Louis Cardinals are notching 4.6 runs per outing, which puts them at 14th in MLB.

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The Cardinals have an ERA of 4.77 for the year (27th in the league), and their staff has struck out 189 hitters. Cardinals pitchers have given up 32 long balls and 142 total runs (25th in the league). They have walked 107 players from the other team and their FIP sits at 4.73 as a unit over the course of the season. St. Louis has conceded 252 base knocks (9.0 per 9 innings) and also 134 earned runs. They have accumulated a K/BB ratio of 1.77 and the pitching staff has earned a collective WHIP of 1.42.

Cardinals bullpen pitchers have entered the contest with runners on base 33 times in addition to having 39 appearances in high leverage situations. The relievers have tallied 21 holds so far this season (6th in MLB). The Cardinals relievers have a save percentage of 62.5% and stepped onto the hill in 38 save situations. They have accumulated 10 saves this season and have blown 6 out of their 16 chances to get a save. The relief pitchers have inherited 48 runners so far this season and 37.5% of those runners earned a run for their team. The Cardinals have dispatched 104 relief pitchers to the mound for the year.

The St. Louis Cardinals have 759 putouts this season, as well as 283 assists and 14 errors. Their fielding percentage is holding at .987 which is 11th in professional baseball, and have a total of 21 double plays. The Cardinals have converted 69.9% of baseballs in play into outs out of their 2,277 innings, which has them sitting at 17th in pro baseball.

Pallante has taken the hill for 485 frames and has earned 341 strikeouts in his career. Pallante (26-31 career win-loss record) has earned a FIP of 4.26 and he has faced 2,097 hitters in the majors. His earned run average is 4.32 (233 earned runs allowed) and his career WHIP is 1.418. He has allowed 494 base hits (9.2 hits per 9 innings) with 194 walks.

The Pittsburgh Pirates have compiled an on-base percentage of .324 in addition to a team batting average of .241 this year. They have struck out on 278 occasions (2nd in the league) and have notched a total of 242 hits. Pittsburgh has compiled 29 home runs so far this year and 132 RBIs. The Pirates hold a slugging percentage of .369 and they average 4.72 runs per outing (12th in baseball). They have hit 37 two-baggers, while walking 110 times as well as scoring 137 runs.

The Pittsburgh pitching staff have given up 115 runs over the course of the season while holding a team ERA of 3.36 (99 earned runs surrendered). They have surrendered 21 homers and they surrender 3.90 runs per 9 innings (5th in the league). The Pirates have a team WHIP of 1.226 with a FIP of 3.56 as a staff on the season. Their K/BB ratio is 9.10 (268 strikeouts vs 112 walks). They rank 5th in MLB as a pitching staff in total hits surrendered with 213.

With 37 save situations, the Pirates have recorded 24 holds in addition to 8 blown saves. Pittsburgh has had relievers take the mound in 13 save opportunities and they have recorded 5 saves. Pittsburgh bullpen pitchers have an inherited score percentage of 26.7% out of their 30 inherited base runners. Their relief pitchers have taken the field 40 times in high leverage situations and on 27 occasions with base runners. They sit at 27th in the league with a save percentage of 38.5%, and they have dispatched 105 relief pitchers to the mound on the season.

The Pittsburgh Pirates have turned 20 double plays and have a fielding percentage of .985 (18th in pro baseball). The Pirates have recorded 233 assists, 16 errors and have earned 796 putouts so far this season. In 2,388 innings on the field, the Pirates hold a defensive efficiency of 71.2% (6th in the majors).

So far in his pro baseball career, Chandler has allowed 45 hits while tallying 52 K's in 55 frames. He has given up a total of 27 ER's while earning a WHIP of 1.180 and being the owner of a FIP of 4.3. He has a strikeout to walk ratio of 2.60 and he has faced 232 hitters during his career. Chandler (5-3 career mark) has earned a 4.41 ERA and has conceded 7.4 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Pittsburgh (-144)

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