St. Louis Cardinals vs San Francisco Giants Prediction, 9/8/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs San Francisco Giants

Date: Tuesday, September 8, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: St. Louis (+110) San Francisco (-132)

The San Francisco Giants (59-84) will play the St. Louis Cardinals (71-72) at Oracle Park on Tuesday. The moneyline on this game has St. Louis at +110 while San Francisco is opening at -132. The betting total is set at 8. The pitchers taking the mound are Quinn Mathews and Landen Roupp.

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The Cardinals have tallied 204 two-baggers as a unit and have hit 153 baseballs out of the park. St. Louis owns a slugging percentage of .386 and have been called out on strikes 1,129 times, while drawing a walk on 453 occasions. As a team, the St. Louis Cardinals are earning 4.5 runs per game, which has them sitting at 11th in the league. They have 629 runs batted in and 1,171 hits for the season, while their team batting average is .243. They have 647 runs scored while having a team OBP of .316.

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They have a strikeout to walk ratio of 2.28 and the pitching staff has a collective WHIP of 1.35. Cardinals pitchers have allowed 142 home runs in addition to 658 runs (20th in the league). St. Louis has given up 1,233 hits (8.7 per 9 innings) and 608 earned runs. The Cardinals are sitting with a team ERA of 4.29 over the course of the season (21st in MLB), and their staff has struck out 1,123 hitters. They have walked 492 opposing batters and their FIP sits at 4.10 as a unit over the course of the season.

Cardinals pitchers have gone to the mound with players on base 146 times and also have had 178 appearances in high leverage situations. The relief pitchers have a total of 93 holds so far this season (4th in the league). The Cardinals relief pitchers have recorded a save percentage of 61.8% and have come into the game in 165 save situations. They have tallied 42 saves over the course of the season and have not converted 26 of 68 chances to get a save. The relievers have inherited 217 runners so far this year with 40.1% of those players earned a run for their team. The Cardinals have dispatched 485 relief pitchers to the hill for the season.

The Cardinals have converted 69.0% of balls hit into play into outs in their 11,469 innings on the diamond, ranking them 24th in pro baseball. The St. Louis Cardinals have a tally of 3,823 putouts on the year, in addition to 1,329 assists and 61 errors. Their fielding percentage is holding steady at .988 which puts them in 4th in baseball, and have accumulated 138 double plays.

Matthews has thrown 24 frames and has earned 24 punch outs in his pro baseball career. His earned run average is 4.46 (12 ER's allowed) and his WHIP is 1.612. He has given up 27 base knocks (10.0 hits per nine innings) with 12 walks. Matthews (1-2 career record) is the owner of a FIP of 4.40 and he has faced 112 opposing batters in the majors.

The San Francisco Giants have compiled a team on-base percentage of .309 as well as a team batting average of .248 so far this season. They have struck out on 1,144 occasions (23rd in MLB) and have earned a total of 1,203 base hits. San Francisco has 164 home runs this season as well as 580 RBIs. The Giants have a team SLG% of .409 and they average 4.20 runs per outing (23rd in baseball). They have notched 237 doubles, while getting a free base 397 times and notching 601 runs.

The Giants hold a team WHIP of 1.361 and have a FIP of 4.20 as a pitching staff this season. They have a ranking of 19th in MLB as a staff in total hits relinquished with 1,184. The San Francisco pitching staff have given up 674 runs so far this season while holding an ERA of 4.39 (615 earned runs relinquished). They have earned a K/BB ratio of 7.70 (1,076 strikeouts against 531 walks). They have surrendered 136 long balls and they surrender 4.81 runs per 9 innings (23rd in the league).

Sitting with 124 save situations, the Giants have tallied 76 holds and 22 blown saves. San Francisco has had relievers step onto the hill in 48 save opportunities and they have come away with 26 saves. San Francisco bullpen pitchers have an inherited score percentage of 36.1% out of 249 inherited runners. Their bullpen pitchers have stepped onto the hill 120 times in high leverage situations in addition to 161 occasions with runners on base. They rank 27th in baseball holding a save percentage of 54.2%, and they have dispatched 455 relievers to the mound for the season.

The San Francisco Giants have gotten 129 double plays and have a fielding percentage of .982 (29th in professional baseball). The Giants have accrued 1,330 assists, 94 errors and have a tally of 3,780 putouts on the season. In 11,340 innings played, the Giants have earned a defensive efficiency of 69.5% (18th in MLB).

Roupp (16-22 career win-loss mark) is the owner of a 3.94 earned run average and has conceded 8.2 hits per nine innings. His K/BB ratio is 2.06 and he has faced 1,307 hitters in his MLB career. He has conceded 132 earned runs while earning a WHIP of 1.375 and a FIP of 3.9. So far in his MLB career, Roupp has conceded 275 base knocks while accumulating 286 strikeouts in 301 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take San Francisco (-132)

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