Tampa Bay Rays vs Cleveland Guardians Prediction, 4/29/2026 MLB Picks, Best Bets & Odds

Game: Tampa Bay Rays vs Cleveland Guardians

Date: Wednesday, April 29, 2026

Location: Progressive Field in Cleveland, OH

TV: MLB.TV

Odds/Point Spread: Tampa Bay (+106) Cleveland (-128)

Progressive Field is the site where the Cleveland Guardians (15-15) will compete against the Tampa Bay Rays (17-11) on Wednesday. The moneyline on this game has Tampa Bay at +106 while Cleveland is at -128. The betting total is set at 8.5. The expected starting pitchers will be Drew Rasmussen and Gavin Williams.

Tampa Bay has a slugging rate of .391 and have struck out 202 times, while drawing a walk on 98 occasions. They have 129 runs batted in in addition to 245 hits this year, while their average at the plate sits at .256. The Rays have earned 38 doubles as a unit and have smacked 27 baseballs out of the park. They have accounted for 135 runs scored and hold an OBP of .332. As a squad, the Tampa Bay Rays are putting up 4.8 runs per game, which has them sitting at 11th in baseball.

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Their strikeout to walk ratio is 2.25 and the pitching staff has a collective WHIP of 1.24. Rays pitchers have allowed 37 home runs and 135 runs (19th in the league). Tampa Bay has yielded 213 base hits (7.6 per 9 innings) as well as 120 earned runs. The Rays have compiled a team ERA of 4.28 on the campaign (18th in MLB), and the staff has struck out 225 hitters. They have walked 100 hitters and their FIP is 4.52 as a team for the year.

The Rays have sent 89 relief pitchers to the mound so far this season. The relief pitchers have inherited 32 base runners for the season and 40.6% of them ended up scoring. The relief pitchers have notched 19 holds on the year (10th in the league). Rays bullpen pitchers have entered the game with runners on base 25 times and also have had 34 appearances in high leverage situations. They have accumulated 11 saves over the course of the season and have blown 4 of 15 chances to get a save. The Rays relief pitchers have recorded a save rate of 73.3% and have come into the game in 34 save situations.

The Tampa Bay Rays have earned 757 putouts for the season, as well as 216 assists and 24 errors. Their fielding percentage is holding steady at .976 which ranks 29th in pro baseball, and have a total of 13 double plays. The Rays have turned 72.7% of balls hit into play into outs in their 2,271 innings on the diamond, ranking them 3rd in professional baseball.

Rasmussen (32-17 career mark) has a FIP of 2.83 and he has faced 1,938 opposing hitters in the major leagues. He has conceded 387 base hits (7.2 hits per nine innings) with 123 free passes. His ERA is 2.87 (155 earned runs allowed) and he has a WHIP of 1.051. Rasmussen has thrown 485 frames and has 454 punch outs in his career.

Cleveland has a total of 31 home runs this year to go along with 115 runs batted in. They have tallied 50 doubles, while taking a walk 116 times as well as earning 120 runs. The Cleveland Guardians have a team OBP of .316 as well as a batting average of .230 so far this season. The Guardians hold a slugging percentage of .378 and they tally 4.00 runs per game (25th in baseball). They have been rung up on 234 occasions (17th in MLB) and have a total of 225 hits.

The Guardians have a team WHIP of 1.254 and are the owners of a FIP of 4.14 as a staff this season. They are currently ranked 14th in MLB as a staff in total hits surrendered with 227. The Cleveland pitching staff have given up 129 runs so far this season while holding a team ERA of 4.04 (118 earned runs yielded). Their K/BB ratio sits at 9.50 (278 strikeouts vs 103 free passes). They have conceded 37 long balls and they give up 4.41 runs per 9 innings (13th in the league).

Cleveland relievers hold an inherited score percentage of 37.8% out of their 45 inherited base runners. Their bullpen pitchers have come in 34 times in high leverage situations and on 27 occasions with base runners. With 32 save situations, the Guardians have accumulated 20 holds in addition to 4 blown saves. They rank 9th in the league with a save rate of 66.7%, and they have sent 96 bullpen pitchers to the mound so far this year.

In 2,370 innings on the diamond, the Guardians hold a defensive efficiency of 70.9% (10th in professional baseball). The Cleveland Guardians have gotten 23 double plays and have a fielding percentage of .988 (7th in the majors). The Guardians have recorded 229 assists, 12 errors and have accounted for 790 putouts for the season.

Williams (22-21 career win-loss record) has earned a 3.52 earned run average while conceding 7.2 hits per nine innings. His strikeout to walk ratio is 2.20 and he has faced 1,523 opposing batters so far in his pro baseball career. He has conceded 141 ER's while holding a WHIP of 1.274 and being the owner of a FIP of 3.5. In his pro baseball career, Williams has conceded 288 base knocks while totaling 377 K's in 360 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Tampa Bay (+106)

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