Tampa Bay Rays vs New York Yankees Prediction, 9/22/2026 MLB Picks, Best Bets & Odds

Game: Tampa Bay Rays vs New York Yankees

Date: Tuesday, September 22, 2026

Location: Yankee Stadium in Bronx, NY

TV: YES

Odds/Point Spread: Tampa Bay (+125) New York (-145)

The Tampa Bay Rays (95-60) are hitting the road to Yankee Stadium on Tuesday where they will play the New York Yankees (89-66). The line on this matchup has Tampa Bay at +125 while New York is sitting at -145. The betting total comes in at 8.5. The expected starting pitchers will be Drew Rasmussen and Max Fried.

The Rays have recorded 217 two-baggers as a team and have smacked 164 balls out of the park. Tampa Bay has a slugging % of .404 and have struck out 1,085 times, while drawing a walk on 495 occasions. As a unit, the Tampa Bay Rays are scoring 4.6 runs per game, which ranks them 11th in the league. They have amassed 672 runs batted in as well as 1,345 base knocks for the year, and their batting average sits at .259. They have accounted for 707 runs scored while holding a team OBP of .328.

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They have accumulated a K/BB ratio of 3.28 and their pitching staff has earned a collective WHIP of 1.13. Rays pitchers have allowed 192 long balls in addition to 624 runs (6th in the league). Tampa Bay has allowed 1,185 base hits (7.7 per 9 innings) in addition to 569 earned runs. The Rays have a team earned run average of 3.70 this season (7th in the league), and the staff has struck out 1,261 batters. Their pitching staff has walked 385 players from the other team and their FIP comes in at 4.03 as a team for the year.

The Rays relief pitchers have a save rate of 75.0% and have entered the game in 187 save situations. They have tallied 57 saves this year and have blown 19 of 76 save chances. The relievers have inherited 182 runners so far this season and 33.0% of those players crossing the plate. Rays bullpen pitchers have gone to the mound with runners on base 128 times and also have had 157 appearances in high leverage situations. The Rays have dispatched 497 relievers to the hill on the campaign. The relievers have recorded 110 holds over the course of the season (1st in MLB).

The Tampa Bay Rays are sitting with 4,152 putouts at this point in the season, in addition to 1,232 assists and 89 errors. Their fielding percentage is holding at .984 which has them sitting 21st in MLB, and have earned 97 double plays. The Rays have turned 72.3% of balls hit into play into outs out of their 12,456 innings on the field, which has them ranked 1st in pro baseball.

Rasmussen (45-22 win-loss record in his career) holds a FIP of 2.81 while he has gone up against 2,485 opposing hitters during his time in the majors. He has allowed 496 hits (7.1 hits per 9 innings) with 148 walks. His ERA is 2.85 (198 ER's allowed) and he has a WHIP of 1.030. Rasmussen has pitched in 625 frames and has tallied 591 strikeouts in his MLB career.

The Yankees have a slugging percentage of .410 and they are recording 4.60 runs per game (9th in the league). They have put up 216 doubles, while getting a free base 554 times as well as putting up 713 runs. New York has accounted for 216 HRs so far this year as well as 681 RBIs. They have been called out on strikes on 1,415 occasions (6th in the league) and have recorded 1,206 hits. The New York Yankees have tallied an on-base percentage of .311 as well as a team batting average of .235 on the season.

The New York pitching staff have given up 576 runs so far this year while holding an ERA of 3.22 (496 earned runs conceded). They have given up 159 home runs and they surrender 3.74 runs per 9 innings (1st in baseball). The Yankees hold a team WHIP of 1.166 with a FIP of 3.71 as a pitching staff over the course of the season. Their strikeout to walk ratio sits at 9.00 (1,390 strikeouts vs 466 bases on balls). They are currently ranked 2nd in MLB as a staff in total hits conceded with 1,151.

New York relievers have an inherited score percentage of 21.5% out of 261 inherited runners. Their relievers have come in 173 times in high leverage situations and on 183 occasions with base runners. Sitting with 161 save situations, the Yankees have accumulated 86 holds and also 28 blown saves. They rank 18th in baseball with a save percentage of 61.1%, and they have dispatched 512 relief pitchers onto the field so far this year.

Out of their 12,486 innings on the field, the Yankees are sitting with a defensive efficiency of 71.3% (5th in baseball). The New York Yankees have turned 120 double plays and have notched a fielding percentage of .984 (22nd in the majors). The Yankees have racked up 1,344 assists, 92 errors and have a total of 4,162 putouts over the course of the season.

During his career, Fried has surrendered 1,020 base knocks and he has 1,152 strikeouts in 1,185 frames. He has given up a total of 395 earned runs while holding a WHIP of 1.137 and a FIP of 3.0. His K/BB ratio is 3.51 and he has gone up against 4,822 opposing hitters during his pro baseball career. Fried (97-45 career win-loss record) has a 3.00 earned run average while surrendering 7.7 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take New York (-145)

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