Toronto Blue Jays vs Baltimore Orioles Prediction, 9/21/2026 MLB Picks, Best Bets & Odds

Game: Toronto Blue Jays vs Baltimore Orioles

Date: Monday, September 21, 2026

Location: Oriole Park at Camden Yards in Baltimore, MD

TV: MASN

Odds/Point Spread: Toronto (-160) Baltimore (+132)

The Baltimore Orioles (75-80) are welcoming the Toronto Blue Jays (76-79) at Oriole Park at Camden Yards on Monday. The moneyline on this matchup has Toronto at -160 while Baltimore is priced at +132. The over/under is 8.5. The pitchers who are expected to start will be Trey Yesavage and Shane Baz.

Toronto has a slugging rate of .383 and have been called out on strikes 1,106 times, while drawing a walk on 435 occasions. They have 591 runs batted in in addition to 1,294 hits over the course of the season, while their average at the plate is sitting at .248. The Blue Jays have hit 243 doubles as a unit and have hit 149 baseballs out of the park. They have accumulated 622 runs while holding a team OBP of .310. As a unit, the Toronto Blue Jays are putting up 4.0 runs per contest, which puts them at 30th in baseball.

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Their K/BB ratio is 2.34 and the pitching staff holds a collective WHIP of 1.30. Blue Jays pitchers have yielded 159 home runs and also 669 total runs (11th in baseball). Toronto has relinquished 1,217 base hits (8.0 per 9 innings) in addition to 600 earned runs. The Blue Jays have compiled a team ERA of 3.92 for the season (9th in baseball), and their staff has rung up 1,348 hitters. They have walked 575 players from the other team and their FIP comes in at 3.99 as a team on the season.

Blue Jays pitchers have entered the contest with opponents on base 166 times and also have had 185 appearances in high leverage situations. The relievers have 99 holds for the year (6th in the league). The Blue Jays bullpen have a save percentage of 76.1% and have come into the game in 171 save situations. They have compiled 51 saves for the season and have not converted 16 of 67 chances to save the game. The relievers have inherited 243 runners so far this year with 25.9% of those players ended up crossing the plate. The Blue Jays have sent 579 relief pitchers to the mound so far this year.

The Toronto Blue Jays have accumulated 4,128 putouts on the year, as well as 1,305 assists and 96 errors. Their fielding percentage is at .983 which has them ranked 26th in the majors, and have 104 double plays. The Blue Jays have turned 70.0% of baseballs in play into outs out of their 12,384 innings on the field, which ranks them 13th in the majors.

Yesavage (6-5 mark in his career) has earned a FIP of 3.56 while he has faced 448 opposing batters in the majors. He has surrendered 74 hits (6.2 hits per nine innings) with 53 free passes. His earned run average is 3.61 (43 ER's allowed) and he has a WHIP of 1.185. Yesavage has taken the ball for 107 frames and has racked up 107 punch outs so far in his MLB career.

The Orioles have a slugging percentage of .395 and they average 4.47 runs per contest (14th in baseball). They have 229 doubles, while getting a free base 566 times and scoring 693 runs. Baltimore has a total of 189 HRs so far this season as well as 668 runs batted in. They have struck out on 1,456 instances (3rd in baseball) and have notched a total of 1,214 hits. The Baltimore Orioles have a team on-base percentage of .315 as well as a batting average of .234 so far this season.

The Orioles have a WHIP of 1.343 and are the owners of a FIP of 4.09 as a squad for the year. They rank 26th in baseball as a pitching staff in total hits surrendered with 1,341. The Baltimore pitching staff have relinquished 721 runs this season while having an ERA of 4.13 (634 earned runs surrendered). Their K/BB ratio is 8.10 (1,250 strikeouts vs 516 free passes). They have yielded 167 homers and they allow 4.69 runs per 9 innings (21st in MLB).

Sitting with 149 save situations, the Orioles have earned 80 holds and 22 blown saves. Baltimore has called on relief pitchers to step onto the mound in 66 save opportunities and they have walked away with 44 saves. Baltimore bullpen pitchers have an inherited score rate of 26.6% out of 218 inherited runners. Their bullpen pitchers have taken the field 168 times in high leverage situations and on 160 occasions with runners on. They rank 11th in the league with a save percentage of 66.7%, and they have sent 523 relievers to the mound on the season.

The Baltimore Orioles have turned 115 double plays and have notched a fielding percentage of .983 (23rd in the majors). The Orioles have recorded 1,319 assists, 92 errors and have earned 4,150 putouts over the course of the season. In 12,450 innings on the diamond, the Orioles have a defensive efficiency of 68.8% (27th in pro baseball).

Thus far in his career, Baz has conceded 422 hits while earning 445 punch outs in 459 innings pitched. He has conceded a total of 214 earned runs while holding a WHIP of 1.275 and having a FIP of 4.1. He has a K/BB ratio of 2.73 and he has faced 1,938 opposing hitters in his MLB career. Baz (23-32 win-loss record in his career) has a 4.20 earned run average and has surrendered 8.3 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Toronto (-160)

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