Toronto Blue Jays vs Baltimore Orioles Prediction, 9/22/2026 MLB Picks, Best Bets & Odds

Game: Toronto Blue Jays vs Baltimore Orioles

Date: Tuesday, September 22, 2026

Location: Oriole Park at Camden Yards in Baltimore, MD

TV: MASN

Odds/Point Spread: Toronto (-160) Baltimore (+132)

The Baltimore Orioles (75-81) are hosting the Toronto Blue Jays (77-79) at Oriole Park at Camden Yards on Tuesday. The moneyline on this matchup has Toronto at -160 while Baltimore is priced at +132. The total is 9. The pitchers taking the mound are Max Scherzer and Chris Bassitt.

As a unit, the Toronto Blue Jays are knocking in 4.0 runs per game, which ranks them 29th in baseball. They have earned a total of 629 runs while holding a team on-base percentage of .311. The Blue Jays have accounted for 247 two-baggers as a team and have hit 149 baseballs out of the stadium. They have 598 RBI's in addition to 1,305 hits on the season, while their average at the plate is .248. Toronto has a slugging % of .383 and have struck out 1,111 times, while taking a walk on 441 occasions.

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The Blue Jays have compiled a team ERA of 3.91 so far this season (9th in the league), and the staff has rung up 1,355 batters. Blue Jays pitchers have yielded 160 home runs and 671 runs (11th in the league). They have walked 579 opposing hitters and their FIP sits at 3.99 as a unit this season. Toronto has conceded 1,225 hits (8.0 per 9 innings) as well as 602 earned runs. Their strikeout to walk ratio is 2.34 and the pitching staff holds a collective WHIP of 1.30.

The Blue Jays have sent 585 relief pitchers to the hill over the course of the season. The relievers have inherited 245 runners on the season and 25.7% of those runners ended up scoring. The relief pitchers have racked up 101 holds this year (6th in MLB). Blue Jays bullpen pitchers have entered the contest with players on base 167 times as well as having 186 appearances in high leverage situations. They have 51 saves for the season and have not converted 16 of 67 chances to save the game. The Blue Jays relief pitchers have a save percentage of 76.1% and have entered the game in 173 save situations.

The Toronto Blue Jays have 4,155 putouts thus far, as well as 1,314 assists and 96 errors. Their fielding rate is holding at .983 which is 26th in professional baseball, and have earned 105 double plays. The Blue Jays have turned 70.0% of balls hit into play into outs in their 12,465 innings on the field, which has them sitting at 13th in MLB.

Scherzer (224-125 career win-loss record) sits with a FIP of 3.24 while he has faced 12,302 opposing batters during his time in the major leagues. He has given up 2,501 hits (7.4 hits per 9 innings) with 810 free passes. His earned run average is 3.29 (1,108 earned runs allowed) and his career WHIP is 1.091. Scherzer has taken the ball for 3,035 innings and has accumulated 3,543 punch outs during his career.

Baltimore has accumulated 189 HRs this season and 668 RBIs. They have notched 229 two-baggers, while walking 569 times as well as racking up 693 runs. The Baltimore Orioles have an on-base percentage of .314 and a team batting average of .234 for the year. The Orioles hold a team slugging % of .394 and they average 4.44 runs per outing (16th in baseball). They have been rung up on 1,464 occasions (3rd in the league) and have a total of 1,218 base knocks.

The Orioles have a WHIP of 1.343 in addition to having a FIP of 4.08 as a pitching staff for the season. Their strikeout to walk ratio is 8.20 (1,264 strikeouts vs 522 bases on balls). They rank 26th in MLB as a staff in total hits relinquished with 1,347. They have relinquished 168 homers and they allow 4.68 runs per 9 innings (21st in baseball). The Baltimore pitching staff have surrendered 724 runs so far this season while holding an ERA of 4.12 (637 earned runs yielded).

Sitting with 149 save situations, the Orioles have accrued 80 holds and 22 blown saves. Baltimore has called on relievers to enter the game in 66 save chances and they have walked away with 44 saves. Baltimore relievers hold an inherited score percentage of 26.4% out of 220 inherited runners. Their relievers have taken the field 168 times in high leverage situations in addition to 161 occasions with runners on. They sit at 12th in MLB with a save rate of 66.7%, and they have sent 526 bullpen pitchers onto the diamond on the campaign.

The Baltimore Orioles have gotten 117 double plays and have a fielding percentage of .984 (23rd in pro baseball). The Orioles have recorded 1,327 assists, 92 errors and are sitting with 4,177 putouts so far this year. In their 12,531 innings played, the Orioles are sitting with a defensive efficiency of 68.8% (27th in baseball).

Bassitt (91-70 win-loss record in his career) is the owner of a 3.71 ERA while giving up 8.5 hits per 9 innings. His strikeout to walk ratio is 2.83 and he has gone up against 5,848 batters thus far in his career. He has allowed a total of 567 earned runs while earning a WHIP of 1.267 and being the owner of a FIP of 3.7. So far in his MLB career, Bassitt has given up 1,297 hits and he has 1,263 punch outs in 1,375 frames.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Toronto (-160)

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