Washington Nationals vs Chicago White Sox Prediction, 4/24/2026 MLB Picks, Best Bets & Odds

Game: Washington Nationals vs Chicago White Sox

Date: Friday, April 24, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Washington (+102) Chicago (-122)

The Washington Nationals (11-14) are en route to Rate Field on Friday where they will take on the Chicago White Sox (9-15). The line on this matchup has the Nationals at +102 and the White Sox are at -122. The total is 8.5. The pitchers taking the mound are Miles Mikolas and Erick Fedde.

As a unit, the Washington Nationals are recording 5.7 runs per contest, which has them sitting at 2nd in the league. They have accounted for 142 runs scored while having a team OBP of .334. The Nationals have tallied 44 two-baggers as a team and have smacked 30 baseballs out of the park. They have 130 RBI's as well as 224 hits on the year, and their batting average is sitting at .255. Washington has a slugging rate of .411 and have struck out 208 times, while drawing a walk on 91 occasions.

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Their strikeout to walk ratio is 1.78 and the pitching staff has earned a collective WHIP of 1.52. Nationals pitchers have yielded 46 home runs and 155 total runs (30th in the league). Washington has relinquished 240 base hits (9.6 per 9 innings) in addition to 142 earned runs. The Nationals hold a team earned run average of 5.65 on the campaign (29th in MLB), and their staff has struck out 185 hitters. Their pitching staff has walked 104 opposing batters and their FIP is 5.72 as a squad on the campaign.

Nationals pitchers have entered the game with opponents on base 24 times in addition to having 22 appearances in high leverage situations. The relievers have recorded 13 holds this season (18th in the league). The Nationals bullpen have compiled a save rate of 38.5% and have entered the game in 30 save situations. They have recorded 5 saves so far this year and have not converted 8 of their 13 save opportunities. The relief pitchers have inherited 38 base runners for the year and 44.7% of those runners crossing the plate. The Nationals have dispatched 87 relievers to the mound for the season.

The Washington Nationals have earned a total of 678 putouts so far this season, as well as 240 assists and 23 errors. Their fielding rate is at .976 which has them sitting 30th in professional baseball, and they have turned 21 double plays. The Nationals have transformed 68.9% of baseballs in play into outs out of their 2,034 innings on the diamond, which has them sitting 21st in baseball.

Mikolas has taken the hill for 1,271 innings and has 910 K's during his pro baseball career. His ERA is 4.32 (610 earned runs allowed) and he has a WHIP of 1.229. He has surrendered 1,306 base knocks (9.2 hits per nine innings) and has 256 free passes. Mikolas (72-78 career record) holds a FIP of 4.25 while going up against 5,316 hitters in the major leagues.

The Chicago White Sox have a team on-base percentage of .315 in addition to a batting average of .222 so far this season. They have been called out on strikes on 224 occasions (8th in the league) and have 176 hits. Chicago has accounted for 31 long balls for the year and 91 RBIs. The White Sox hold a slugging % of .387 and they score 4.17 runs per outing (19th in MLB). They have hit 28 two-baggers, while taking a walk 96 times and racking up 100 runs.

The White Sox are sitting with a team WHIP of 1.508 with a FIP of 4.82 as a staff this season. Their strikeout to walk ratio comes in at 7.70 (180 strikeouts against 116 free passes). They rank 20th in the league as a staff in total hits conceded with 201. They have relinquished 26 home runs and they give up 5.52 runs per 9 innings (27th in the league). The Chicago pitching staff have given up 129 runs over the course of the season while holding an ERA of 5.14 (120 earned runs relinquished).

Sitting with 24 save situations, the White Sox have earned 10 holds and 8 blown saves. Chicago has had bullpen pitchers enter the game in 14 save opportunities and they have come away with 6 saves. Chicago relief pitchers have an inherited score rate of 35.3% out of 51 inherited base runners. Their relievers have taken the field 26 times in high leverage situations and on 31 occasions with runners on base. They are ranked 26th in the league with a save percentage of 42.9%, and they have dispatched 90 bullpen pitchers to the mound for the season.

In their 1,896 innings on the field, the White Sox have a defensive efficiency of 69.8% (19th in baseball). The Chicago White Sox have gotten 18 double plays and own a fielding percentage of .984 (24th in MLB). The White Sox have recorded 212 assists, 14 errors and have notched a total of 632 putouts this year.

In his pro baseball career, Fedde has surrendered 818 base knocks while totaling 604 K's in 792 innings. Fedde (34-58 career win-loss mark) holds a 4.92 earned run average while allowing 9.3 hits per 9 innings. He has surrendered a total of 433 ER's while earning a WHIP of 1.432 and having a FIP of 4.8. His strikeout to walk ratio is 1.91 and he has faced 3,445 batters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (-122)

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