Washington Nationals vs Cleveland Guardians Prediction, 5/27/2026 MLB Picks, Best Bets & Odds

Game: Washington Nationals vs Cleveland Guardians

Date: Wednesday, May 27, 2026

Location: Progressive Field in Cleveland, OH

TV: MLB.TV

Odds/Point Spread: Washington (+106) Cleveland (-128)

Progressive Field is the site where the Cleveland Guardians (32-24) will try to defeat the Washington Nationals (28-27) on Wednesday. The odds on this game have the Nationals at +106 and the Guardians are sitting at -128. The total is set at 9. The pitchers taking the mound will be Miles Mikolas and Gavin Williams.

Washington has a slugging rate of .422 and have been called out on strikes 466 times, while being walked on 199 occasions. They have earned 280 runs batted in in addition to 466 base knocks for the year, while their average at the plate is .245. The Nationals have tallied 107 doubles as a team and have hit 71 baseballs out of the park. They have a total of 298 runs and hold an on-base percentage of .324. As a squad, the Washington Nationals are knocking in 5.4 runs per game, which is 1st in the league.

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Their K/BB ratio is 2.22 and their pitching staff has a collective WHIP of 1.38. Nationals pitchers have given up 77 home runs and also 304 runs in total (30th in baseball). Washington has allowed 490 hits (8.9 per 9 innings) and also 263 earned runs. The Nationals hold a team earned run average of 4.75 on the season (26th in baseball), and they have rung up 438 hitters. Their pitching staff has walked 197 opposing batters and their FIP is 4.72 as a team over the course of the season.

Nationals relief pitchers have gone to the mound with runners on base 55 times in addition to having 66 appearances in high leverage situations. The relief pitchers have accumulated 29 holds this year (18th in the league). The Nationals bullpen have earned a save percentage of 53.3% and have come into the game in 63 save situations. They have recorded 16 saves so far this season and have blown 14 out of their 30 chances to save the game. The relief pitchers have inherited 76 runners over the course of the season and 46.1% of those players crossing the plate. The Nationals have sent 179 relief pitchers to the hill over the course of the season.

The Nationals have turned 69.2% of balls hit into play into outs out of their 4,488 innings on the field, which has them sitting at 25th in professional baseball. The Washington Nationals have 1,496 putouts thus far, in addition to 488 assists and 50 errors. Their fielding percentage is currently at .975 which has them sitting 30th in baseball, and have a total of 40 double plays.

Mikolas has pitched in 1,298 innings and has totaled 926 K's so far in his pro baseball career. His ERA is 4.31 (622 earned runs allowed) and his WHIP is 1.223. He has surrendered 1,328 base hits (9.2 hits per nine innings) and has 260 walks. Mikolas (73-78 career record) holds a FIP of 4.25 while going up against 5,421 opposing hitters in the majors.

The Guardians hold a team slugging % of .373 and they have an average of 4.18 runs per game (18th in the league). They have 88 two-baggers, while taking a walk 233 times as well as earning 234 runs. Cleveland has recorded 56 home runs over the course of the season to go along with 224 RBIs. They have struck out on 417 occasions (26th in the league) and have recorded 416 hits. The Cleveland Guardians have a team on-base percentage of .320 and a team batting average of .228 on the season.

The Guardians hold a team WHIP of 1.258 and have a FIP of 3.91 as a team this year. Their strikeout to walk ratio comes in at 9.50 (526 strikeouts against 190 bases on balls). They are currently ranked 17th in the league as a pitching staff in total hits conceded with 434. They have surrendered 65 long balls and they concede 3.97 runs per 9 innings (7th in MLB). The Cleveland pitching staff have surrendered 219 runs on the campaign while having a team ERA of 3.63 (200 earned runs surrendered).

With 74 save situations, the Guardians have accrued 48 holds and also 4 blown saves. Cleveland has called on bullpen pitchers to take the mound in 25 save chances and they have walked away with 21 saves. Cleveland relief pitchers have an inherited score rate of 24.4% of 82 inherited base runners. Their relievers have taken the field 65 times in high leverage situations and also on 52 occasions with runners on base. They sit at 2nd in baseball holding a save percentage of 84.0%, and they have dispatched 181 bullpen pitchers to the hill over the course of the season.

In 4,467 innings played, the Guardians have earned a efficiency on defense of 70.2% (20th in MLB). The Cleveland Guardians have gotten 41 double plays and hold a fielding percentage of .989 (7th in MLB). The Guardians have accrued 427 assists, 22 errors and have earned a total of 1,489 putouts on the campaign.

So far in his career, Williams has surrendered 323 hits and he has 417 punch outs in 394 frames. Williams (25-23 record in his career) has earned a 3.49 ERA and has conceded 7.4 hits per 9 innings. He has conceded 153 earned runs while earning a WHIP of 1.260 and being the owner of a FIP of 3.4. His K/BB ratio is 2.40 and he has faced 1,658 batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cleveland (-128)

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