Louisville Cardinals vs Cincinnati Bearcats Prediction, 11/21/2025 College Basketball Picks, Best Bets & Odds

Game: Louisville Cardinals vs Cincinnati Bearcats

Date: Friday, November 21, 2025

Location: Heritage Bank Center in Cincinnati, OH

TV: ESPN+

The Cincinnati Bearcats (4-0) will take on the Louisville Cardinals (4-0) at Heritage Bank Center on Friday.

The Louisville Cardinals took the court against Ohio and earned the victory with a final of 106-81 in their last contest. In the matter of personal fouls, the Cardinals ended up walking away with 25 and Ohio accumulated 20 personal fouls. They also made 9 of their 26 attempts from three-point range. Ohio finished the game shooting 76.9% when shooting free throws by knocking down 20 of their 26 shots. Furthermore, Ohio snagged 31 rebounds (11 offensive, 20 defensive), but didn't record a block for the team. Ohio distributed 12 dimes and had 9 steals in this game. Concerning defense, Louisville allowed their opponent to shoot 44.1% from the floor on 26 out of 59 shooting. They also doled out 23 assists in the matchup while forcing the other team into 15 turnovers and having 11 steals. Pertaining to hauling in boards, they collected a total of 39 with 16 of them being of the offensive variety. From the free throw line, the Cardinals converted 22 of their 30 attempts for a rate of 73.3%. Louisville wrapped up the contest having earned a 50.0% FG percentage (34 out of 68) and made 16 out of their 35 3-point shots.

Ryan Conwell is a guy who was a factor for the game. He walked away from this one shooting 50.0% from the field and recorded 3 assists. He played for 27 minutes and pulled down 6 boards. He scored 22 points on 7 of 14 shooting.

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Louisville comes into this contest with a win-loss mark of 4-0 so far this year. They cough up possession 11.0 times per game and as a group are committing 20.8 fouls per contest. As a unit, Louisville is grabbing 44.3 boards per contest and has accounted for 90 assists this year, which is 43rd in college in terms of passing the rock. The Cardinals are connecting on 36.4% from downtown (51 of 140) and 73.6% from the charity stripe. They average 103.0 points per outing (2nd in Division 1) on 50.0% from the floor.

On the defensive end, the Cardinals are forcing their opponents into 17.0 turnovers per game and they draw 22.0 personal fouls. They are currently ranked 38th in D-1 in giving up assists to the opposition with 41 surrendered on the year. The Cardinals defense is giving up a shooting percentage of 38.9% (96 of 247) and they concede 34.5 boards per contest as a unit. They are giving up 32.1% from 3-point land and they are 149th in the nation in PPG from their opponents (71.0).

When they last stepped on the court, the Cincinnati Bearcats got the victory with a final of 72-55 against Mount St. Mary's. The Bearcats recorded 29 defensive boards and 14 offensive rebounds totaling 43 in the matchup. They also turned the ball over 10 times, while earning 8 steals in this game. Mount St. Mary's committed 23 personal fouls for the matchup which got the Bearcats to the free throw line for 30 tries. They were able to convert 18 of them for a percentage of 60.0%. When discussing shots from downtown, Cincinnati made 6 out of their 29 tries (20.7%). At the conclusion of this game, the Bearcats finished shooting 24 out of 64 from the floor which gave them a rate of 37.5%. The Bearcats allowed Mount St. Mary's to convert 21 of their 56 tries from the field which gave them a percentage of 37.5% in this matchup. They finished 37.0% from behind the 3-point line by shooting 10 of 27 and ended up shooting 3 out of 10 from the free throw line (30.0%). When discussing how they rebounded, Cincinnati allowed Mount St. Mary's to get 34 in total (6 on the offensive side).

Day Day Thomas was important for the Bearcats for the game. He converted 4 out of 6 in the matchup giving him a rate of 66.7%, and had 5 rebounds. He had 16 points in his 26 minutes on the hardwood and earned 5 assists in the matchup.

Cincinnati has a record of 4-0 on the season. When it comes to offensive execution, the Bearcats are connecting on 44.3% from the field, which has them ranked 226th in the country. Cincinnati has scored 314 points so far this year (78.5 per game) and they pull in 41.3 rebounds per game. They are getting an assist 16.5 times per contest (123rd in the country) and they are turning it over 16.3 times per contest. The Bearcats commit 18.0 personal fouls every game and they hit 63.4% from the free throw line.

The Bearcats defensively are ranked 18th in college in points given up per game with 61.0. They are forcing their opponents into 17.8 turnovers on a nightly basis and allow teams to shoot 35.6% from the field (16th in college). The Cincinnati defense concedes 27.0% on 3-point shots (27 of 100) and their opposition knocks down 68.1% of their shots from the free throw line. They allow 12.0 dimes and 35.3 rebounds every game, which is ranked 131st and 192nd in the nation.

Who will win tonight's NCAA game against the spread?

Guy Bruhn's Pick: Take Cincinnati

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