Chicago Blackhawks vs Buffalo Sabres Prediction, 11/21/2025 NHL Picks, Best Bets & Odds

Game: Chicago Blackhawks vs Buffalo Sabres

Date: Friday, November 21, 2025

Location: KeyBank Center in Buffalo, NY

TV: MSG Network

Odds/Point Spread: Blackhawks (-182) Sabres (+150)

The Chicago Blackhawks (10-5-4) are traveling to KeyBank Center on Friday where they will take on the Buffalo Sabres (7-9-4). The moneyline on this matchup has Chicago at -182 while Buffalo is priced at +150. The over/under is set at 6.5.

The Chicago Blackhawks were on the right side of the scoreboard with a 5-2 victory over the Flames their last time on the ice. Chicago compiled 60 penalty mins in this outing. The Blackhawks had a impressive offensive performance in the victory. Additionally, they had 4 power play opportunities but weren't able to score a goal. For the game, they scored on 5 out of the 23 shots they put on goal.

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Chicago Blackhawks opponents have 70 power play opportunities (3rd in professional hockey) and have scored 11 goals in those attempts. The Blackhawks have had 595 shots attempted against them and have earned a save percentage of .919. Chicago has taken 478 shots and has a shooting percentage of 13.4%. While playing at even strength, the Blackhawks have conceded 37 goals while having 51 themselves. Chicago has accumulated 56 power play chances and they have scored 13 goals out of those chances, garnering them a percentage of 23.21%. For the current campaign, they have tallied 24 points and their points percentage is sitting at .632. In reference to their scoring capabilities, the Chicago Blackhawks have accounted for 64 goals (10th in the league) so far this season and have conceded 48.

The player in the crease for this game is Arvid Soderblom. Opponents have racked up 301 goals against Soderblom in his pro hockey career and his goals against average per game is 3.63. Soderblom has participated in 92 games throughout his pro hockey career. He has a save percentage of .890 for his 4,573 minutes guarding the cage. He has accumulated an overall mark of 20-54-12 and he started in 83 games. From the beginning of his pro career to now, Soderblom has compiled 35 quality starts and his rate for quality starts is .422. Soderblom has had 2,748 shot attempts against him and has accrued 2,447 total saves.

In their last game, Buffalo faced the Flames in a game where the Sabres took the defeat by a tally of 6-2. The Sabres notched 2 goals of the 30 shots on goal they attempted. They had 3 opportunities on the power play in this matchup but didn't put one in the back of the net.

Buffalo has taken 559 shots (17th in pro hockey) and has accumulated a shot percentage of 10.20%, while allowing the other team 639 shots. They have recorded a penalty kill rate of 89.83% on their opponents 59 power play chances, and their save percentage is 88.9%. They have a total of 61 opportunities on the power play and they have accumulated a power play rate of 16.39%. The Sabres have racked up 47 goals at even strength and 10 goals (24th in hockey) while having a power play advantage. They have granted a total of 71 goals to be scored by way of 65 goals at even strength and 6 goals while they had less men on the ice. For the year, the Buffalo Sabres have a total of 57 goals, 18 points, and a points percentage of .450.

Across the ice you will find Alex Lyon in net. Lyon is the owner of a lifetime mark of 54-43-14 and has participated in 125 games. Lyon's quality start percentage sits at 52.7% and he has qualified for 59 quality starting assignments in his NHL career. He has accounted for 3,115 saves out of the 3,452 shots taken against him, giving him a rate of .902. His opposition is averaging 3.01 goals per contest and he has relinquished 337 goals altogether. He got the starting nod in 112 games and has racked up 6,017 minutes.

Who will win tonight's NHL game against the spread or moneyline?

Tony's Pick: Take Chicago (-182)

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