St. Louis Blues vs Buffalo Sabres Prediction, 11/6/2025 NHL Picks, Best Bets & Odds

Game: St. Louis Blues vs Buffalo Sabres

Date: Thursday, November 6, 2025

Location: KeyBank Center in Buffalo, NY

TV: MSG Network

Odds/Point Spread: Blues (+125) Sabres (-150)

The St. Louis Blues (4-7-2) are traveling to KeyBank Center on Thursday where they will play the Buffalo Sabres (5-4-4). The line on this matchup has St. Louis at +125 while Buffalo is at -150. The over/under is 6.

The St. Louis Blues came out of this game feeling pretty good about themselves with a 3-2 win against the Oilers in their last outing. St. Louis recorded 2 penalty minutes for this contest. In addition, they had 2 power play attempts and netted 1 goal. The Blues had an average offensive output in this win. In the game, they finished 3 out of the 22 shots they tried.

Get all of our NHL Betting Picks

At even strength, the Blues have surrendered 41 goals while notching 28 on the offensive side of the ice. St. Louis Blues opponents have amassed 34 power play opportunities (29th in pro hockey) and have a total of 11 goals in those chances. When discussing their goal scoring prowess, the St. Louis Blues have earned 37 goals (25th in the NHL) on the campaign and have surrendered 52. St. Louis has taken 355 shots and holds a shot percentage of 10.4%. For the current campaign, they have accumulated 10 points and their points percentage is .385. The Blues so far have had 333 shots taken against them and hold a save percentage of .844. St. Louis is sitting with 36 power play chances and they have notched 9 goals out of those attempts, giving them a percentage of 25.00%.

Protecting the goal for this matchup will be Jordan Binnington. Binnington has participated in 346 matchups during his hockey career. He has earned an overall record of 176-120-38 and he started in 335 games. Opponents have notched 929 goals versus Binnington in his pro career and his goals against average is 2.77. Binnington has had 9,857 shots taken against him and has accrued 8,928 saves. His save percentage currently is at .906 in his 17,831 mins in the crease. Over the course of his pro career, Binnington has accrued 180 quality starts and his rate for quality starts is .537.

Their last time out, Buffalo faced off against the Mammoth in a matchup where the Sabres ended up losing by a tally of 2-1. The Sabres scored 1 goal out of the 18 shots on goal they tried. They had 2 power play opportunities in this game but weren't able to score a goal.

The Sabres are sitting with 29 goals at even strength and 8 goals (21st in the NHL) while on the power play. Buffalo has tried 384 shots (13th in hockey) and has accumulated a shooting percentage of 9.64%, while allowing the other team 420 shots. So far this season, the Buffalo Sabres have 37 goals, 14 points, as well as a points percentage of .538. They have permitted 40 goals to be scored by of a combination of 36 goals at even strength and 4 goals while they had less men on the ice. They have recorded 42 power play chances and they have accumulated a power play percentage of 19.05%. They have recorded a penalty kill percentage of 90.91% on the other teams 44 power play opportunities, and their save percentage comes in at 90.5%.

Across the rink you are likely to see Ukko-Pekka Luukkonen in the crease. Luukkonen is sitting with a career record of 72-65-16 and has played in 157 games. Luukkonen's percentage of quality starts is 53.6% and he has 82 quality starts in his career. He has accounted for 4,036 saves out of 4,496 shots taken against him, which gives him a rate of .898. Opponents are averaging 3.01 goals per game and he has yielded 460 goals altogether. He has started in 153 contests and has been on the ice for 8,220 mins.

Who will win tonight's NHL game against the spread or moneyline?

Guy's Pick: Take Buffalo (-150)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NHL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.