Philadelphia Flyers vs Buffalo Sabres Prediction, 10/21/2026 NHL Picks, Best Bets & Odds

Game: Philadelphia Flyers vs Buffalo Sabres

Date: Wednesday, October 21, 2026

Location: KeyBank Center in Buffalo, NY

TV: NBC Sports Philadelphia, MSG Network

Odds/Point Spread: Flyers (+160) Sabres (-184)

The Buffalo Sabres (4-3-2) welcome the Philadelphia Flyers (2-6-3) at KeyBank Center on Wednesday. The moneyline on this contest has Philadelphia at +160 while Buffalo is at -184. The over/under comes in at 6.

The Philadelphia Flyers went home feeling good about their game by earning a 3-2 win against the Avalanche in their previous game. The Flyers offense didn't overly impress in the win. In the outing, they scored on 3 of the 24 shots they tried. Furthermore, they had 2 chances on the power play and scored 1 goal. Philadelphia tallied 4 penalty mins in this game.

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Concerning their scoring, the Philadelphia Flyers have accumulated 17 goals (29th in the league) on the season and have surrendered 35. For the current campaign, they have 7 points and their points % is .318. Philadelphia skates onto the rink with 31 power play chances and they have notched 4 goals out of those attempts, garnering them a rate of 12.90%. While at even strength, the Flyers have allowed the opponent to score 29 goals while scoring 13 on offense. Philadelphia has taken 236 shots and holds a shooting percentage of 7.2%. The Flyers thus far have had 355 shots taken against them and are the owners of a save percentage of .901. Philadelphia Flyers opponents have tallied 39 power play opportunities (1st in pro hockey) and have scored 6 goals in those attempts.

The player between the pipes for this game is Daniel Vladar. Opponents have racked up 435 goals against Vladar in his NHL career and his goals against average per contest is 2.88. Vladar has taken the ice for 162 games during his hockey career. His save percentage sits at .898 in his 385 mins on the ice. He has a win-loss record of 79-51-24 and he has started in 151 games. In his career, Vladar is sitting with 88 quality starts and his percentage for quality starts is .583. Vladar has seen 4,253 shots against him and has recorded 3,819 saves.

In their last game, Buffalo played the Canadiens in a game where the Sabres ended up taking the loss by a tally of 4-3. They had 4 opportunities on the power play in this game but weren't able to notch a goal. The Sabres notched 3 goals out of the 26 shots on goal they were seeking.

During this campaign, the Buffalo Sabres have earned a total of 27 goals, 10 points, in addition to a points percentage of .556. They have permitted 33 goals to be scored by way of 22 goals at even strength and 11 goals while they had less men on the ice. The Sabres have earned 24 goals at even strength and 3 goals (28th in the league) while having a power play advantage. They have earned 33 power play opportunities and they have a power play percentage of 9.09%. Buffalo has attempted 241 shots (14th in hockey) and has a shot percentage of 11.20%, while allowing the other team 231 shots. They have recorded a penalty kill percentage of 64.52% on their opponents 31 power play chances, and their save percentage comes in at 85.7%.

Across the ice you will find Ukko-Pekka Luukkonen defending the net. Teams are averaging 2.94 goals/game and he has conceded 562 goals overall. Luukkonen's rate of quality starts comes out to 53.9% and he has qualified for 103 quality starting assignments in his professional career. He has started in 191 games and has played 10,928 minutes. Luukkonen has a career record of 96-76-20 and has been in net for 197 games. He has racked up 4,981 stops out of 5,541 shots attempted, giving him a save percentage of .899.

Who will win tonight's NHL game against the spread or moneyline?

Guy's Pick: Take Buffalo (-184)

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