Arizona Diamondbacks vs Chicago White Sox Prediction, 6/25/2025 MLB Picks, Best Bets & Odds

Game: Arizona Diamondbacks vs Chicago White Sox

Date: Wednesday, June 25, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Arizona (-130) Chicago (+110)

The Chicago White Sox (25-54) are hosting the Arizona Diamondbacks (40-38) at Rate Field on Wednesday. The moneyline on this game has Arizona at -130 while Chicago is at +110. The total comes in at 9. The starting pitchers will be Zac Gallen and Sean Burke.

The Diamondbacks have tallied 143 doubles as a team and have knocked 113 baseballs out of the stadium. Arizona has a slugging percentage of .451 and have been called out on strikes 605 times, while taking a walk on 284 occasions. As a unit, the Arizona Diamondbacks are knocking in 5.2 runs per game, which puts them at 3rd in the league. They have 398 RBI's as well as 679 base knocks on the season, while their batting average is at .256. They are sitting with 406 runs while holding a team on-base percentage of .333.

Get all of our MLB Parlay Picks

The Diamondbacks hold a team earned run average of 4.74 so far this season (25th in the league), and the staff has struck out 666 hitters. Diamondbacks pitchers have relinquished 103 home runs and also 399 runs in total (27th in baseball). They have walked 260 opposing players and their FIP sits at 4.36 as a unit this season. Arizona has yielded 673 hits (8.7 per 9 innings) in addition to 366 earned runs. They have a strikeout to walk ratio of 2.56 and their pitching staff holds a collective WHIP of 1.34.

The Diamondbacks relief pitchers have a save percentage of 63.2% and have stepped onto the mound in 84 save situations. The relievers have inherited 86 base runners so far this season and 33.7% of those players crossed home plate. Diamondbacks pitchers have stepped onto the hill with runners on base 65 times in addition to having 76 appearances in high leverage situations. The Diamondbacks have dispatched 242 relief pitchers to the hill so far this season. The relievers have recorded 44 holds for the year (17th in the league). They have 24 saves on the year and have blown 14 of 38 chances to save the game.

The Diamondbacks have turned 69.2% of balls hit into play into outs out of 6,249 innings on the field, which ranks them 19th in pro baseball. The Arizona Diamondbacks have earned a total of 2,083 putouts this season, in addition to 696 assists and 38 errors. Their fielding rate is currently at .987 which has them ranked 15th in the majors, and they have turned 60 double plays.

Gallen has pitched in 906 frames and has earned 971 K's in his MLB career. Gallen (58-45 career mark) has a FIP of 3.47 while he has gone up against 3,728 batters in the major leagues. His earned run average is 3.53 (355 ER's allowed) and he has a WHIP of 1.162. He has surrendered 754 base hits (7.5 hits per 9 innings) and has 299 walks.

The Chicago White Sox have recorded an OBP of .293 and a batting average of .220 for the year. They have been rung up on 697 occasions (4th in baseball) and have recorded 568 base hits. Chicago has accounted for 60 long balls this season as well as 259 RBIs. The White Sox have a slugging percentage of .341 and they average 3.44 runs per contest (28th in the league). They have tallied 120 two-baggers, while getting a free base 260 times and scoring 272 runs.

The Chicago pitching staff have given up 355 runs on the year while having an ERA of 4.26 (324 earned runs given up). They have surrendered 86 dingers and they yield 4.67 runs per 9 innings (23rd in MLB). The White Sox have a team WHIP of 1.414 in addition to having a FIP of 4.52 as a pitching staff on the season. Their K/BB ratio comes in at 7.50 (570 strikeouts against 290 free passes). They sit at 24th in the league as a staff in total hits relinquished with 677.

Chicago relief pitchers have an inherited score percentage of 26.6% out of 109 inherited base runners. Their bullpen pitchers have come in 72 times in high leverage situations in addition to 76 occasions with runners on. Sitting with 59 save situations, the White Sox have earned 37 holds and 14 blown saves. They are currently ranked 30th in MLB holding a save percentage of 36.4%, and they have dispatched 253 relievers to the hill so far this year. Chicago has had relief pitchers step onto the hill in 22 save chances and they have earned 8 saves.

In their 6,159 innings played, the White Sox are sitting with a efficiency on defense of 69.0% (20th in baseball). The Chicago White Sox have gotten 65 double plays and hold a fielding percentage of .982 (27th in MLB). The White Sox have recorded 649 assists, 50 errors and have 2,053 putouts for the season.

Burke (5-7 career mark) has earned a 3.88 ERA while surrendering 8.1 hits per nine innings. His strikeout to walk ratio is 1.98 and he has faced 409 hitters so far in his pro baseball career. He has given up 41 earned runs while holding a WHIP of 1.337 and a FIP of 3.8. So far in his career, Burke has given up 85 base hits and he has 83 punch outs in 95 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Arizona (-130)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here