Arizona Diamondbacks vs San Diego Padres Prediction, 9/26/2025 MLB Picks, Best Bets & Odds

Game: Arizona Diamondbacks vs San Diego Padres

Date: Friday, September 26, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Arizona (+120) San Diego (-144)

The San Diego Padres (87-72) are hosting the Arizona Diamondbacks (80-78) at Petco Park on Friday. The moneyline on this game has the Diamondbacks at +120 and the Padres are at -144. The total comes in at 8. The pitchers who are expected to start are Zac Gallen and Yu Darvish.

As a unit, the Arizona Diamondbacks are notching 5.0 runs per game, which ranks them 4th in MLB. They have accounted for 782 runs and hold an on-base percentage of .325. The Diamondbacks have accounted for 271 two-baggers as a unit and have hit 210 balls out of the park. They have recorded 761 runs batted in and 1,348 base knocks for the season, and their batting average is sitting at .252. Arizona has a slugging percentage of .434 and have been called out on strikes 1,271 times, while taking a walk on 527 occasions.

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Their strikeout to walk ratio is 2.59 and their pitching staff has a collective WHIP of 1.31. Diamondbacks pitchers have conceded 187 home runs and 753 runs (23rd in MLB). Arizona has allowed 1,362 base knocks (8.7 per 9 innings) and also 693 earned runs. The Diamondbacks have compiled a team ERA of 4.42 on the year (23rd in baseball), and the staff has rung up 1,254 hitters. They have walked 485 opposing players and their FIP is 4.24 as a team for the year.

Diamondbacks pitchers have come into the game with runners on base 146 times in addition to having 164 appearances in high leverage situations. The bullpen have racked up 88 holds so far this season (14th in the league). The Diamondbacks relief pitchers have recorded a save percentage of 59.2% and have stepped onto the mound in 164 save situations. They have earned 42 saves on the year and have not converted 29 of 71 chances to save the game. The relief pitchers have inherited 192 base runners this season with 33.3% of them ended up crossing the plate. The Diamondbacks have sent 489 relief pitchers to the mound this season.

The Diamondbacks have converted 69.6% of balls in play into outs out of 12,699 innings, which has them sitting 20th in professional baseball. The Arizona Diamondbacks have accounted for 4,233 putouts so far this season, in addition to 1,412 assists and 80 errors. Their fielding percentage sits at .986 which has them ranked 16th in professional baseball, and have a total of 125 double plays.

Gallen has thrown 1,002 innings and has earned 1,057 punch outs so far in his career. Gallen (66-51 career mark) holds a FIP of 3.50 while going up against 4,118 hitters in the major leagues. His ERA is 3.56 (396 earned runs allowed) and his WHIP is 1.154. He has surrendered 836 base hits (7.5 hits per 9 innings) and has had 321 walks.

The Padres have a team SLG% of .388 and they score 4.26 runs per contest (19th in MLB). They have put up 248 two-baggers, while taking a walk 499 times as well as putting up 678 runs. San Diego has compiled 147 home runs so far this year and 639 runs batted in. They have been rung up on 1,137 occasions (28th in baseball) and have a total of 1,339 hits. The San Diego Padres have recorded an OBP of .320 as well as a batting average of .252 on the campaign.

The Padres hold a team WHIP of 1.203 in addition to having a FIP of 4.01 as a unit so far this year. They have earned a strikeout to walk ratio of 8.90 (1,392 strikeouts vs 519 free passes). They are currently ranked 1st in the league as a pitching staff in total hits conceded with 1,173. They have allowed 174 long balls and they concede 3.92 runs per 9 innings (2nd in the league). The San Diego pitching staff have surrendered 612 runs on the campaign while having a team ERA of 3.64 (569 earned runs yielded).

San Diego relief pitchers hold an inherited score rate of 29.4% of 255 inherited base runners. Their bullpen pitchers have stepped onto the mound 208 times in high leverage situations in addition to 181 occasions with base runners. With 172 save situations, the Padres have accrued 103 holds in addition to 16 blown saves. They sit at 1st in the league holding a save percentage of 75.0%, and they have sent 564 relief pitchers to the hill on the season. San Diego has called on relievers to take the mound in 64 save opportunities and they have walked away with 48 saves.

The San Diego Padres have turned 114 double plays and have earned a fielding percentage of .987 (10th in baseball). The Padres have 1,208 assists, 73 errors and have a tally of 4,218 putouts for the season. Out of their 12,654 innings played, the Padres are sitting with a efficiency on defense of 71.8% (3rd in professional baseball).

In his career, Darvish has surrendered 1,454 base knocks while he has accumulated 2,071 punch outs in 1,773 innings pitched. Darvish (114-93 record in his career) has earned a 3.65 earned run average and has conceded 7.4 hits per nine innings. He has surrendered 719 ER's while holding a WHIP of 1.136 and being the owner of a FIP of 3.6. He has a strikeout to walk ratio of 3.69 and he has gone up against 7,285 opposing batters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-144)

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