Baltimore Orioles vs Chicago White Sox Prediction, 9/17/2025 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs Chicago White Sox

Date: Wednesday, September 17, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Baltimore (-160) Chicago (+132)

Rate Field is the location where the Chicago White Sox (57-94) will compete against the Baltimore Orioles (70-80) on Wednesday. The line on this matchup has the Orioles at -160 and the White Sox are at +132. The total has been set at 8.5. The pitchers taking the mound are Tyler Wells and Martin Perez.

The Orioles have compiled 238 doubles as a unit and have smacked 177 balls out of the stadium. Baltimore has a slugging rate of .398 and have struck out 1,331 times, while being walked on 440 occasions. As a squad, the Baltimore Orioles are earning 4.3 runs per outing, which puts them at 22nd in MLB. They have 606 runs batted in in addition to 1,201 hits on the campaign, while their team batting average sits at .239. They have accumulated 639 runs scored and have an OBP of .307.

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The Orioles have an ERA of 4.61 on the year (25th in the league), and the staff has struck out 1,237 hitters. Orioles pitchers have given up 199 home runs and 730 total runs (25th in the league). Their pitching staff has walked 483 players from the other team and their FIP is 4.42 as a team on the campaign. Baltimore has allowed 1,337 hits (9.1 per 9 innings) and 679 earned runs. Their strikeout to walk ratio sits at 2.56 and their pitching staff has recorded a WHIP of 1.37.

The Orioles have sent 501 relief pitchers to the hill on the season. The relief pitchers have inherited 202 base runners on the season and 26.2% of those runners earned a run for their team. They have compiled 35 saves for the year and have missed out on 20 of their 55 chances to save the game. The Orioles relief pitchers have a save percentage of 63.6% and have entered the game in 158 save situations. The relief pitchers have a total of 99 holds over the course of the season (4th in baseball). Orioles relief pitchers have come into the game with opponents on base 145 times as well as having 159 appearances in high leverage situations.

The Atlanta Braves have amassed 3,980 putouts so far this season, as well as 1,325 assists and 83 errors. Their fielding percentage is holding at .985 which has them sitting 20th in baseball, and have accumulated 110 double plays. The Orioles have transformed 68.4% of baseballs in play into outs out of their 11,940 innings on the diamond, which has them ranked 26th in professional baseball.

Wells (17-18 win-loss mark in his career) has earned a FIP of 3.95 while he has faced 1,226 opposing hitters in the major leagues. He has given up 237 hits (7.0 hits per 9 innings) and has 78 walks. His ERA is 4.01 (136 earned runs allowed) and he has a career WHIP of 1.031. Wells has pitched in 305 innings and has tallied 281 strikeouts so far in his career.

Chicago has 151 HRs over the course of the season to go along with 581 RBIs. They have 231 doubles, while walking 467 times and scoring 601 runs. The Chicago White Sox hold an OBP of .303 as well as a team batting average of .234 for the season. The White Sox hold a slugging percentage of .374 and they average 3.98 runs per game (26th in baseball). They have struck out on 1,271 occasions (14th in the league) and have notched a total of 1,172 hits.

The Chicago pitching staff have given up 687 runs this season and come in with a team ERA of 4.21 (618 earned runs surrendered). They have surrendered 172 long balls and they yield 4.68 runs per 9 innings (20th in MLB). The White Sox have a team WHIP of 1.358 in addition to having a FIP of 4.49 as a unit for the year. Their K/BB ratio is 8.00 (1,170 strikeouts vs 557 bases on balls). They come in at 15th in baseball as a pitching staff in total hits allowed with 1,236.

Chicago has had bullpen pitchers step onto the hill in 44 save opportunities and they have walked away with 23 saves. They are ranked 29th in the league holding a save rate of 52.3%, and they have sent 489 bullpen pitchers to the hill on the campaign. Their relief pitchers have taken the field 141 times in high leverage situations in addition to 151 occasions with base runners. Chicago relief pitchers have an inherited score percentage of 32.4% of 219 inherited base runners. With 110 save situations, the White Sox have amassed 64 holds and also 21 blown saves.

In 11,883 innings played, the White Sox have earned a defensive efficiency of 69.9% (15th in MLB). The Chicago White Sox have gotten 122 double plays and have accounted for a fielding rate of .982 (28th in MLB). The White Sox have racked up 1,200 assists, 95 errors and have amassed 3,961 putouts during this campaign.

In his career, Perez has given up 1,745 hits while tallying 1,151 punch outs in 1,627 innings pitched. Perez (91-92 win-loss record in his career) has earned a 4.41 ERA and has allowed 9.7 hits per nine innings. He has surrendered a total of 797 ER's while holding a WHIP of 1.434 and having a FIP of 4.3. His strikeout to walk ratio is 1.96 and he has faced 7,052 batters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Baltimore (-160)

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