Baltimore Orioles vs Cleveland Guardians Prediction, 7/21/2025 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs Cleveland Guardians

Date: Monday, July 21, 2025

Location: Progressive Field in Cleveland, OH

TV: CLEGuardians.TV

Odds/Point Spread: Baltimore (+126) Cleveland (-152)

The Cleveland Guardians (46-49) will try to defeat the Baltimore Orioles (43-52) at Progressive Field on Monday. The odds on this game have the Orioles at +126 and the Guardians are sitting at -152. The over/under is set at 8. The pitchers expected to start will be Tomoyuki Sugano and Tanner Bibee.

Baltimore has a slugging percentage of .398 and have been called out on strikes 831 times, while being walked on 264 occasions. They have accounted for 371 RBI's and 760 hits so far this season, while their team batting average is .239. The Orioles have hit 150 doubles as a team and have knocked 111 baseballs out of the park. They have racked up 393 runs scored while having a team OBP of .305. As a unit, the Baltimore Orioles are putting up 4.1 runs per outing, which puts them at 21st in the league.

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Their strikeout to walk ratio is 2.59 and the pitching staff holds a collective WHIP of 1.41. Orioles pitchers have allowed 132 home runs in addition to 483 runs (26th in the league). Baltimore has surrendered 877 hits (9.4 per 9 innings) as well as 458 earned runs. The Orioles are sitting with a team ERA of 4.92 on the year (27th in MLB), and the staff has struck out 784 hitters. Their pitching staff has walked 303 opposing hitters and their FIP comes in at 4.46 as a unit so far this year.

Orioles bullpen pitchers have stepped onto the hill with players on base 106 times in addition to having 98 appearances in high leverage situations. The bullpen have racked up 69 holds so far this year (2nd in the league). The Orioles relievers have accumulated a save percentage of 65.7% and have come into the game in 107 save situations. They have accumulated 23 saves on the season and have blown 12 of their 35 save opportunities. The relief pitchers have inherited 138 base runners on the year with 18.8% of them ended up crossing the plate. The Orioles have dispatched 336 relief pitchers to the mound this season.

The Atlanta Braves have earned 2,512 putouts at this point in the season, in addition to 834 assists and 51 errors. Their fielding rate is at .985 which ranks 22nd in pro baseball, and they have turned 66 double plays. The Orioles have turned 67.6% of baseballs in play into outs out of their 7,536 innings on the field, which ranks them 29th in MLB.

Sugano has taken the ball for 99 frames and has accumulated 59 K's during his pro baseball career. Sugano (7-5 career mark) has a FIP of 4.38 while he has gone up against 422 opposing hitters during his time in the majors. His ERA is 4.45 (49 ER's allowed) and he has a WHIP of 1.302. He has surrendered 107 base knocks (9.7 hits per nine innings) with 22 walks.

The Cleveland Guardians hold a team OBP of .294 and a batting average of .222 this year. They have struck out on 781 occasions (18th in the league) and have a total of 690 base knocks. Cleveland has accounted for 98 home runs on the year as well as 338 runs batted in. The Guardians have a team SLG% of .366 and they average 3.72 runs per game (26th in the league). They have notched 135 two-baggers, while taking a walk 297 times as well as earning 353 runs.

The Cleveland pitching staff have surrendered 398 runs this season while having an ERA of 3.92 (367 earned runs relinquished). They have conceded 100 long balls and they surrender 4.25 runs per 9 innings (15th in the league). The Guardians have a team WHIP of 1.340 and have a FIP of 4.09 as a unit this season. Their K/BB ratio is 8.60 (803 strikeouts against 352 walks). They are currently ranked 15th in MLB as a staff in total hits given up with 778.

With 108 save situations, the Guardians have tallied 69 holds and 12 blown saves. Cleveland has called on bullpen pitchers to enter the game in 38 save opportunities and they have tallied 26 saves. Their bullpen pitchers have stepped onto the mound 107 times in high leverage situations and on 83 occasions with base runners. Cleveland bullpen pitchers hold an inherited score rate of 37.1% out of 116 inherited base runners. They are currently ranked 6th in the league holding a save rate of 68.4%, and they have sent 321 relief pitchers onto the field for the season.

In 7,590 innings on the field, the Guardians have a defensive efficiency of 68.9% (24th in MLB). The Cleveland Guardians have turned 75 double plays and have earned a fielding percentage of .980 (28th in the majors). The Guardians have 760 assists, 66 errors and have notched a total of 2,530 putouts on the season.

Thus far in his career, Bibee has conceded 374 base knocks and he has 423 K's in 424 innings pitched. He has conceded a total of 166 earned runs while earning a WHIP of 1.169 and a FIP of 3.5. His strikeout to walk ratio is 3.47 and he has faced 1,751 batters in his MLB career. Bibee (27-21 win-loss record in his career) has earned a 3.52 ERA while allowing 7.9 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cleveland (-152)

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