Baltimore Orioles vs San Diego Padres Prediction, 9/1/2025 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs San Diego Padres

Date: Monday, September 1, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Baltimore (+172) San Diego (-210)

The San Diego Padres (75-59) are welcoming the Baltimore Orioles (60-74) at Petco Park on Monday. The moneyline on this game has the Orioles at +172 and the Padres are coming in at -210. The betting total is set at 8.5. The pitchers taking the mound will be Kyle Bradish and Dylan Cease.

As a squad, the Baltimore Orioles are notching 4.3 runs per game, which ranks them 18th in baseball. They have earned 574 runs and hold an on-base percentage of .305. The Orioles have tallied 217 doubles as a team and have knocked 160 balls out of the stadium. They have recorded 543 runs batted in in addition to 1,080 hits on the campaign, and their batting average sits at .240. Baltimore has a slugging rate of .402 and have been called out on strikes 1,165 times, while taking a walk on 372 occasions.

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The Orioles hold a team ERA of 4.67 for the season (26th in the league), and their staff has struck out 1,104 hitters. Orioles pitchers have relinquished 183 home runs in addition to 654 total runs (24th in MLB). They have walked 427 hitters and their FIP sits at 4.45 as a team over the course of the season. Baltimore has conceded 1,194 base hits (9.1 per 9 innings) and 614 earned runs. They have a strikeout to walk ratio of 2.59 and their pitching staff holds a collective WHIP of 1.37.

Orioles relief pitchers have entered the game with runners on base 131 times and also have had 137 appearances in high leverage situations. The bullpen are sitting with 87 holds over the course of the season (6th in the league). The Orioles relievers have accumulated a save percentage of 63.3% and have come into the game in 140 save situations. They have accumulated 31 saves on the season and have blown 18 of their 49 chances to get a save. The bullpen pitchers have inherited 178 runners on the campaign and 25.8% of them crossed the plate. The Orioles have dispatched 448 relief pitchers to the hill on the campaign.

The Orioles have turned 68.5% of baseballs in play into outs in their 10,575 innings, which has them ranked 28th in baseball. The Atlanta Braves have notched a total of 3,525 putouts over the course of the season, as well as 1,166 assists and 69 errors. Their fielding rate is at .986 which has them ranked 18th in professional baseball, and have earned 93 double plays.

Bradish has taken the hill for 325 innings and has accumulated 332 K's so far in his career. Bradish (18-14 record in his career) has a FIP of 3.52 while he has gone up against 1,343 opposing hitters in the major leagues. His earned run average is 3.57 (129 ER's allowed) and he has a WHIP of 1.178. He has given up 278 hits (7.7 hits per nine innings) and has had 105 free passes.

The San Diego Padres have accounted for an on-base percentage of .321 and a batting average of .251 this year. They have been rung up on 938 occasions (28th in the league) and have recorded 1,123 hits. San Diego is sitting with 116 long balls over the course of the season as well as 529 RBIs. The Padres hold a slugging percentage of .385 and they have an average of 4.21 runs per outing (23rd in baseball). They have hit 219 doubles, while getting a free base 430 times and putting up 564 runs.

The Padres have a team WHIP of 1.194 with a FIP of 3.95 as a team for the season. They rank 1st in MLB as a staff in total hits given up with 977. The San Diego pitching staff have surrendered 510 runs for the season while having a team ERA of 3.60 (473 earned runs yielded). Their strikeout to walk ratio comes in at 8.70 (1,150 strikeouts vs 437 free passes). They have allowed 139 long balls and they concede 3.88 runs per 9 innings (2nd in the league).

San Diego relievers hold an inherited score percentage of 28.0% out of 218 inherited base runners. Their relievers have taken the field 182 times in high leverage situations and also on 154 occasions with runners on base. Sitting with 153 save situations, the Padres have earned 90 holds and 15 blown saves. They sit at 1st in baseball with a save percentage of 74.1%, and they have dispatched 470 relief pitchers to the hill this season. San Diego has had relievers take the mound in 58 save opportunities and they have recorded 43 saves.

Out of their 10,656 innings played, the Padres have a defensive efficiency of 72.1% (2nd in the majors). The San Diego Padres have turned 100 double plays and hold a fielding percentage of .987 (12th in pro baseball). The Padres have recorded 1,010 assists, 61 errors and have earned a total of 3,552 putouts for the season.

So far in his pro baseball career, Cease has surrendered 830 base knocks and he has 1,199 strikeouts in 989 innings pitched. He has surrendered a total of 429 earned runs while holding a WHIP of 1.264 and having a FIP of 3.8. He has a strikeout to walk ratio of 2.85 and he has faced 4,194 hitters during his pro baseball career. Cease (63-57 record in his career) has earned a 3.90 earned run average and has conceded 7.6 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Baltimore (+172)

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