Baltimore Orioles vs San Diego Padres Prediction, 9/3/2025 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs San Diego Padres

Date: Wednesday, September 3, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Baltimore (+120) San Diego (-144)

The San Diego Padres (76-62) will try to defeat the Baltimore Orioles (62-76) at Petco Park on Wednesday. The odds on this game have Baltimore at +120 while San Diego is coming in at -144. The over/under is 8.5. The pitchers taking the mound are Cade Povich and Nestor Cortes.

As a squad, the Baltimore Orioles are earning 4.3 runs/g, which ranks them 17th in MLB. They have earned a total of 599 runs while holding a team OBP of .307. The Orioles have tallied 228 doubles as a unit and have hit 165 balls out of the park. They have amassed 567 runs batted in as well as 1,124 base knocks for the year, while their average at the plate sits at .242. Baltimore is slugging .405 and have struck out 1,207 times, while drawing a walk on 387 occasions.

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The Orioles have an earned run average of 4.71 so far this year (26th in the league), and their staff has struck out 1,134 batters. Orioles pitchers have given up 187 long balls and 686 runs in total (26th in MLB). Their pitching staff has walked 442 opposing players and their FIP sits at 4.46 as a unit on the campaign. Baltimore has surrendered 1,240 base hits (9.2 per 9 innings) and 638 earned runs. They have accumulated a K/BB ratio of 2.57 and their pitching staff sits with a WHIP of 1.38.

The Orioles bullpen have accumulated a save rate of 64.0% and have stepped onto the mound in 142 save situations. The bullpen pitchers have inherited 184 base runners for the season and 25.5% of those players crossed home plate. Orioles bullpen pitchers have come into the game with opponents on base 134 times as well as having 139 appearances in high leverage situations. The Orioles have sent 459 relief pitchers to the mound on the year. The relievers have a total of 88 holds so far this season (6th in the league). They have 32 saves for the year and have blown 18 of their 50 save chances.

The Atlanta Braves have earned a total of 3,654 putouts on the year, as well as 1,207 assists and 76 errors. Their fielding percentage sits at .985 which ranks 20th in pro baseball, and have accumulated 98 double plays. The Orioles have turned 68.2% of balls hit into play into outs in their 10,962 innings, which has them sitting at 28th in baseball.

Povich (5-16 mark in his career) is the owner of a FIP of 5.05 and he has gone up against 747 opposing batters during his time in the major leagues. He has allowed 178 hits (9.4 hits per nine innings) and has had 66 walks. His ERA is 5.13 (97 ER's allowed) and he has a WHIP of 1.434. Povich has taken the hill for 170 innings and has accounted for 169 punch outs so far in his pro baseball career.

San Diego has knocked in 119 home runs this year to go along with 550 RBIs. They have put up 224 two-baggers, while getting a free base 445 times as well as scoring 585 runs. The San Diego Padres have compiled an OBP of .322 and a team batting average of .252 on the campaign. The Padres hold a slugging % of .385 and they have an average of 4.24 runs per contest (22nd in the league). They have been rung up on 971 occasions (28th in MLB) and have a total of 1,161 hits.

The San Diego pitching staff have surrendered 531 runs this season while having an ERA of 3.64 (492 earned runs surrendered). They have surrendered 143 home runs and they allow 3.92 runs per 9 innings (2nd in baseball). The Padres hold a team WHIP of 1.202 and are the owners of a FIP of 3.96 as a team for the season. Their strikeout to walk ratio is 8.70 (1,184 strikeouts vs 451 bases on balls). They are sitting at 1st in baseball as a pitching staff in total hits given up with 1,013.

Sitting with 153 save situations, the Padres have amassed 90 holds and 15 blown saves. San Diego has called on bullpen pitchers to enter the contest in 58 save chances and they have earned 43 saves. Their relief pitchers have taken the field 184 times in high leverage situations and on 159 occasions with runners on base. San Diego relief pitchers have an inherited score percentage of 28.8% out of 226 inherited runners. They are ranked 1st in MLB holding a save rate of 74.1%, and they have sent 487 bullpen pitchers onto the field for the season.

The San Diego Padres have gotten 100 double plays and have a fielding percentage of .987 (11th in the majors). The Padres have recorded 1,039 assists, 63 errors and have accumulated 3,654 putouts during this campaign. Out of their 10,962 innings played, the Padres are sitting with a defensive efficiency of 71.9% (2nd in pro baseball).

So far in his pro baseball career, Cortes Jr has allowed 530 hits while he has totaled 602 strikeouts in 600 innings. Cortes Jr (35-24 career win-loss mark) is the owner of a 3.87 ERA while giving up 8.0 hits per nine innings. He has surrendered 258 earned runs while holding a WHIP of 1.178 and a FIP of 3.8. His K/BB ratio is 3.40 and he has faced 2,473 hitters during his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Baltimore (+120)

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