Chicago Cubs vs Cincinnati Reds Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Cincinnati Reds

Date: Sunday, September 21, 2025

Location: Great American Ball Park in Cincinnati, OH

TV: FanDuel Sports Network Ohio

Odds/Point Spread: Chicago (-122) Cincinnati (+102)

Great American Ball Park is where the Cincinnati Reds (77-76) will take on the Chicago Cubs (88-65) on Sunday. The line on this contest has the Cubs at -122 and the Reds are priced at +102. The total is set at 8.5. The starting pitchers will be Javier Assad and Zack Littell.

The Cubs have tallied 252 doubles as a squad and have hit 205 baseballs out of the park. Chicago has a slugging % of .426 and have struck out 1,199 times, while drawing a walk on 529 occasions. As a team, the Chicago Cubs are scoring 4.9 runs per game, which has them sitting at 7th in the league. They have compiled 724 RBI's as well as 1,292 base knocks over the course of the season, while their team batting average is at .249. They have notched a total of 743 runs scored while holding a team on-base percentage of .321.

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They have accumulated a K/BB ratio of 3.07 and the pitching staff sits with a WHIP of 1.18. Cubs pitchers have conceded 185 home runs and 611 runs in total (5th in the league). Chicago has given up 1,220 hits (8.1 per 9 innings) in addition to 573 earned runs. The Cubs hold a team ERA of 3.80 on the year (7th in baseball), and the staff has struck out 1,187 batters. They have walked 387 opposing batters and their FIP comes in at 4.14 as a squad on the campaign.

The Cubs relievers have earned a save rate of 68.9% and have come into the game in 170 save situations. The relief pitchers have inherited 135 runners so far this year and 32.6% of those runners ended up scoring. Cubs pitchers have come into the game with opponents on base 96 times in addition to having 153 appearances in high leverage situations. The Cubs have dispatched 497 relief pitchers to the mound over the course of the season. The relievers have tallied 106 holds so far this year (3rd in the league). They have recorded 42 saves so far this year and have blown 19 of 61 chances to get a save.

The Boston Red Sox have a total of 4,047 putouts for the season, in addition to 1,274 assists and 58 errors. Their fielding percentage sits at .989 which ranks 5th in pro baseball, and they have turned 115 double plays. The Cubs have turned 71.7% of baseballs in play into outs out of their 12,141 innings on the field, which has them ranked 3rd in the majors.

Assad has taken the mound for 321 innings and has earned 263 K's during his career. Assad (17-12 career win-loss mark) sits with a FIP of 3.42 while he has faced 1,369 opposing batters in the major leagues. His ERA is 3.47 (124 ER's allowed) and he has a career WHIP of 1.342. He has conceded 298 hits (8.3 hits per 9 innings) and has 133 free passes.

The Cincinnati Reds have accumulated a team OBP of .316 and a batting average of .245 so far this season. They have been called out on strikes on 1,333 occasions (9th in baseball) and have tallied 1,263 base knocks. Cincinnati is sitting with 153 HRs over the course of the season as well as 645 runs batted in. The Reds have a team slugging % of .390 and they score 4.46 runs per outing (13th in the league). They have put up 240 doubles, while getting a free base 501 times as well as notching 683 runs.

The Cincinnati pitching staff have surrendered 656 runs this season and come in with a team ERA of 3.94 (593 earned runs given up). They have surrendered 183 dingers and they allow 4.36 runs per 9 innings (16th in MLB). The Reds are sitting with a team WHIP of 1.234 and are the owners of a FIP of 4.17 as a team on the campaign. Their strikeout to walk ratio comes in at 8.60 (1,296 strikeouts vs 470 walks). They are sitting at 8th in the league as a staff in total hits conceded with 1,200.

Cincinnati bullpen pitchers have an inherited score rate of 33.3% of 207 inherited runners. Their relief pitchers have taken the field 159 times in high leverage situations and also on 139 occasions with runners on. With 152 save situations, the Reds have compiled 92 holds and also 22 blown saves. They are ranked 19th in baseball holding a save rate of 61.4%, and they have dispatched 517 relievers to the hill for the season. Cincinnati has had relievers enter the contest in 57 save chances and they have recorded 35 saves.

The Cincinnati Reds have gotten 96 double plays and have earned a fielding percentage of .984 (23rd in professional baseball). The Reds have racked up 1,166 assists, 84 errors and have a tally of 4,032 putouts on the season. In their 12,096 innings on the field, the Reds have earned a defensive efficiency of 70.9% (5th in professional baseball).

Thus far in his career, Littell has given up 591 base knocks and he has 489 K's in 593 frames. Littell (33-29 record in his career) has a 3.90 ERA and has allowed 9.0 hits per nine innings. He has conceded a total of 257 ER's while holding a WHIP of 1.219 and a FIP of 3.8. His K/BB ratio is 3.70 and he has gone up against 2,475 opposing hitters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cincinnati (+102)

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