Chicago Cubs vs Houston Astros Prediction, 6/28/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Houston Astros

Date: Saturday, June 28, 2025

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: Chicago (+106) Houston (-128)

The Chicago Cubs (47-33) are traveling to Daikin Park on Saturday where they will attempt to beat the Houston Astros (47-33). The odds on this game have Chicago at +106 while Houston is opening at -128. The total has been set at 8. The pitchers taking the mound will be Colin Rea and Ryan Gusto.

The Cubs have accumulated 141 two-baggers as a unit and have hit 118 balls out of the park. Chicago has a slugging percentage of .445 and have struck out 629 times, while drawing a walk on 277 occasions. As a unit, the Chicago Cubs are scoring 5.4 runs per game, which ranks them 2nd in the league. They have recorded 426 runs batted in in addition to 708 hits over the course of the season, while their batting average is .255. They have earned a total of 434 runs while holding a team OBP of .325.

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The Cubs are sitting with a team earned run average of 3.90 so far this season (16th in the league), and their staff has struck out 608 batters. Cubs pitchers have surrendered 95 home runs and also 337 total runs (15th in baseball). Their pitching staff has walked 222 opposing hitters and their FIP sits at 4.14 as a squad for the year. Chicago has allowed 677 base hits (8.5 per 9 innings) as well as 310 earned runs. They have accumulated a K/BB ratio of 2.74 and the pitching staff holds a collective WHIP of 1.26.

The Cubs relief pitchers have compiled a save rate of 66.7% and have entered the game in 79 save situations. The bullpen pitchers have inherited 81 runners on the year with 32.1% of those runners ended up scoring. Cubs bullpen pitchers have entered the contest with runners on 60 times and also have had 90 appearances in high leverage situations. The Cubs have sent 268 relievers to the hill this year. The relief pitchers are sitting with 49 holds on the season (12th in the league). They have compiled 18 saves on the season and have not converted 9 of 27 save chances.

The Cubs have turned 70.4% of balls hit into play into outs out of 6,441 innings on the diamond, which has them sitting at 13th in professional baseball. The Boston Red Sox have 2,147 putouts for the season, as well as 692 assists and 35 errors. Their fielding percentage is currently at .988 which has them sitting 7th in MLB, and they have turned 72 double plays.

Rea has taken the mound for 519 innings and has tallied 420 punch outs in his MLB career. Rea (30-23 win-loss record in his career) is the owner of a FIP of 4.49 and he has gone up against 2,216 opposing hitters during his time in the majors. His ERA is 4.56 (263 ER's allowed) and his WHIP is 1.294. He has conceded 515 base knocks (8.9 hits per 9 innings) with 157 free passes.

The Astros have a SLG% of .400 and they are earning 4.20 runs per contest (20th in MLB). They have tallied 115 doubles, while walking 235 times as well as scoring 336 runs. Houston is sitting with 86 HRs over the course of the season as well as 320 runs batted in. They have been rung up on 624 instances (24th in MLB) and have totaled 684 hits. The Houston Astros have accounted for an on-base percentage of .322 in addition to a team batting average of .256 this year.

The Houston pitching staff have conceded 287 runs this season while holding an ERA of 3.44 (270 earned runs conceded). They have given up 84 long balls and they give up 3.65 runs per 9 innings (2nd in the league). The Astros have a team WHIP of 1.150 and have a FIP of 3.55 as a unit for the season. Their K/BB ratio comes in at 10.00 (784 strikeouts vs 240 walks). They are sitting at 1st in baseball as a pitching staff in total hits relinquished with 573.

Houston has called on relievers to enter the contest in 32 save opportunities and they have come away with 24 saves. They rank 2nd in MLB with a save rate of 75.0%, and they have sent 247 relievers to the hill so far this season. Their bullpen pitchers have taken the field 81 times in high leverage situations and also on 58 occasions with runners on base. Houston relief pitchers have an inherited score rate of 28.2% out of their 85 inherited runners. With 83 save situations, the Astros have recorded 51 holds and 8 blown saves.

The Houston Astros have gotten 50 double plays and have a fielding percentage of .986 (17th in baseball). The Astros have recorded 605 assists, 38 errors and have earned a total of 2,123 putouts for the season. Out of their 6,369 innings played, the Astros have a defensive efficiency of 71.1% (7th in professional baseball).

So far in his career, Gusto has surrendered 66 base knocks and he has 67 punch outs in 60 innings pitched. Gusto (5-3 mark in his career) has earned a 4.64 earned run average while allowing 9.9 hits per 9 innings. He has allowed a total of 31 earned runs while earning a WHIP of 1.481 and having a FIP of 4.6. He has a strikeout to walk ratio of 2.91 and he has faced 270 batters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Houston (-128)

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