Chicago Cubs vs Houston Astros Prediction, 6/29/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Houston Astros

Date: Sunday, June 29, 2025

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: Chicago (+126) Houston (-152)

The Houston Astros (48-33) will play the Chicago Cubs (48-33) at Daikin Park on Sunday. The moneyline on this contest has the Cubs at +126 while the Astros are priced at -152. The over/under is set at 9. The pitchers who are expected to start are Jameson Taillon and Framber Valdez.

As a squad, the Chicago Cubs are notching 5.4 runs/g, which is 2nd in the league. They have tallied 437 runs and have an on-base percentage of .325. The Cubs have accrued 141 two-baggers as a squad and have knocked 119 balls out of the stadium. They have amassed 428 runs batted in in addition to 717 base knocks on the season, while their average at the plate comes in at .256. Chicago is slugging .444 and have struck out 634 times, while being walked on 280 occasions.

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Their strikeout to walk ratio sits at 2.73 and the pitching staff has earned a collective WHIP of 1.25. Cubs pitchers have yielded 95 home runs and also 337 runs in total (15th in the league). Chicago has yielded 680 base knocks (8.5 per 9 innings) as well as 310 earned runs. The Cubs are sitting with a team earned run average of 3.85 so far this season (13th in the league), and their staff has struck out 615 batters. They have walked 225 opposing hitters and their FIP is 4.12 as a team this season.

The Cubs bullpen have a save percentage of 67.9% and have come into the game in 83 save situations. The relief pitchers have inherited 81 base runners this year with 32.1% of them ended up scoring. Cubs bullpen pitchers have entered the game with runners on 60 times as well as having 90 appearances in high leverage situations. The Cubs have dispatched 272 relief pitchers to the hill so far this year. The relief pitchers have recorded 52 holds on the year (7th in the league). They have recorded 19 saves over the course of the season and have blown 9 of their 28 save opportunities.

The Cubs have turned 70.6% of balls hit into play into outs out of 6,522 innings on the diamond, ranking them 11th in MLB. The Boston Red Sox have notched a total of 2,174 putouts for the season, as well as 696 assists and 35 errors. Their fielding rate is holding steady at .988 which has them sitting 7th in the majors, and they have turned 72 double plays.

Taillon has taken the mound for 1,197 innings and has tallied 1,045 punch outs in his pro baseball career. Taillon (78-58 career win-loss record) sits with a FIP of 3.88 while he has gone up against 4,976 batters in the majors. His ERA is 3.94 (524 ER's allowed) and his WHIP is 1.202. He has conceded 1,153 base knocks (8.7 hits per nine innings) with 286 free passes.

Houston has accumulated 86 home runs so far this season to go along with 322 RBIs. They have recorded 116 two-baggers, while getting a free base 235 times and scoring 338 runs. The Houston Astros hold a team on-base percentage of .321 in addition to a team batting average of .255 on the campaign. The Astros have a SLG% of .399 and they score 4.17 runs per contest (21st in MLB). They have struck out on 635 occasions (22nd in MLB) and have 691 base hits.

The Houston pitching staff have surrendered 288 runs on the season while holding an ERA of 3.41 (271 earned runs conceded). They have surrendered 84 home runs and they relinquish 3.62 runs per 9 innings (2nd in baseball). The Astros have a WHIP of 1.142 in addition to having a FIP of 3.51 as a staff on the campaign. Their strikeout to walk ratio is 10.00 (798 strikeouts vs 241 free passes). They have a ranking of 1st in baseball as a staff in total hits given up with 577.

Houston relievers hold an inherited score rate of 27.9% out of 86 inherited base runners. Their relief pitchers have taken the field 83 times in high leverage situations in addition to 59 occasions with runners on. With 84 save situations, the Astros have accrued 51 holds in addition to 9 blown saves. They are ranked 5th in baseball with a save percentage of 72.7%, and they have dispatched 249 relief pitchers to the hill for the season. Houston has called on bullpen pitchers to enter the game in 33 save opportunities and they have come away with 24 saves.

The Houston Astros have turned 51 double plays and have earned a fielding percentage of .986 (16th in pro baseball). The Astros have 614 assists, 38 errors and have accounted for 2,150 putouts this season. In their 6,450 innings played, the Astros have earned a defensive efficiency of 71.2% (7th in professional baseball).

In his career, Valdez has conceded 820 base hits while he has accumulated 968 strikeouts in 991 innings pitched. Valdez (76-45 career mark) is the owner of a 3.26 earned run average while conceding 7.4 hits per nine innings. He has given up 359 earned runs while holding a WHIP of 1.188 and a FIP of 3.2. He has a K/BB ratio of 2.70 and he has gone up against 4,095 batters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Houston (-152)

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