Chicago White Sox vs Cleveland Guardians Prediction, 9/14/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Cleveland Guardians

Date: Sunday, September 14, 2025

Location: Progressive Field in Cleveland, OH

TV: CLEGuardians.TV

Odds/Point Spread: Chicago (+102) Cleveland (-122)

The Cleveland Guardians (75-71) host the Chicago White Sox (57-90) at Progressive Field on Sunday. The line on this matchup has Chicago at +102 and Cleveland is priced at -122. The over/under has been set at 8. The expected starting pitchers will be Yoendrys Gomez and Slade Cecconi.

The White Sox have tallied 228 doubles as a squad and have smacked 150 baseballs out of the park. Chicago is slugging .378 and have been called out on strikes 1,226 times, while taking a walk on 461 occasions. As a team, the Chicago White Sox are compiling 4.1 runs per outing, which puts them at 26th in the league. They have accumulated 577 RBI's and 1,153 hits this season, and their batting average is .236. They have earned 597 runs and have an on-base percentage of .305.

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Their strikeout to walk ratio is 2.11 and their pitching staff has a collective WHIP of 1.36. White Sox pitchers have allowed 166 home runs and 673 runs in total (21st in the league). Chicago has relinquished 1,211 hits (8.5 per 9 innings) and 604 earned runs. The White Sox have a team ERA of 4.22 so far this season (20th in baseball), and they have struck out 1,147 hitters. They have walked 544 opposing hitters and their FIP sits at 4.47 as a team on the year.

White Sox bullpen pitchers have gone to the mound with runners on 148 times and also have had 141 appearances in high leverage situations. The bullpen have 64 holds on the year (27th in baseball). The White Sox relief pitchers have a save percentage of 52.3% and have entered the game in 110 save situations. They have earned 23 saves so far this season and have blown 21 of 44 save chances. The relief pitchers have inherited 215 runners over the course of the season and 32.1% of them ended up crossing the plate. The White Sox have dispatched 479 relievers to the mound on the year.

The White Sox have turned 69.7% of balls in play into outs out of their 11,586 innings, which has them sitting 17th in pro baseball. The Chicago Cubs have earned 3,862 putouts this season, in addition to 1,168 assists and 95 errors. Their fielding percentage is currently at .981 which has them sitting 28th in professional baseball, and have accumulated 118 double plays.

Gomez (3-2 win-loss mark in his career) has a FIP of 4.64 and he has faced 275 hitters during his time in the majors. He has given up 56 hits (8.5 hits per nine innings) and has 33 walks. His ERA is 4.71 (31 ER's allowed) and his WHIP is 1.503. Gomez has pitched in 59 innings and has accounted for 59 punch outs so far in his career.

The Cleveland Guardians are sitting with an OBP of .296 as well as a batting average of .225 on the year. They have been called out on strikes on 1,209 instances (17th in baseball) and have accounted for 1,077 base hits. Cleveland has compiled 149 home runs for the season to go along with 550 runs batted in. The Guardians hold a slugging % of .369 and they average 3.90 runs per contest (27th in MLB). They have put up 213 two-baggers, while taking a walk 445 times and putting up 570 runs.

The Guardians hold a team WHIP of 1.301 and have a FIP of 4.10 as a unit so far this season. Their K/BB ratio is 8.40 (1,206 strikeouts against 495 bases on balls). They are currently ranked 14th in the league as a staff in total hits given up with 1,192. They have allowed 156 long balls and they allow 4.22 runs per 9 innings (11th in MLB). The Cleveland pitching staff have given up 608 runs this season while holding a team ERA of 3.86 (556 earned runs given up).

Cleveland bullpen pitchers hold an inherited score percentage of 33.5% out of 188 inherited runners. Their relief pitchers have come in 168 times in high leverage situations and on 135 occasions with runners on. With 160 save situations, the Guardians have accumulated 95 holds and 19 blown saves. They rank 4th in the league holding a save rate of 69.4%, and they have sent 479 bullpen pitchers onto the diamond for the year. Cleveland has called on bullpen pitchers to step onto the hill in 62 save chances and they have converted 43 saves.

The Cleveland Guardians have gotten 112 double plays and hold a fielding percentage of .983 (27th in MLB). The Guardians have recorded 1,204 assists, 89 errors and have a tally of 3,891 putouts so far this season. In 11,673 innings played, the Guardians hold a defensive efficiency of 69.6% (19th in professional baseball).

In his career, Cecconi has surrendered 234 hits while he has earned 178 K's in 219 innings pitched. He has given up a total of 127 earned runs while earning a WHIP of 1.296 and being the owner of a FIP of 5.1. He has a strikeout to walk ratio of 3.56 and he has gone up against 932 hitters thus far in his career. Cecconi (8-14 career win-loss mark) has earned a 5.22 earned run average while allowing 9.6 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (+102)

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