Chicago White Sox vs Detroit Tigers Prediction, 9/6/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Detroit Tigers

Date: Saturday, September 6, 2025

Location: Comerica Park in Detroit, MI

TV: FanDuel Sports Network Detroit

Odds/Point Spread: Chicago (+132) Detroit (-160)

The Chicago White Sox (52-88) are headed to Comerica Park on Saturday where they will take on the Detroit Tigers (81-60). The odds on this game have the White Sox at +132 while the Tigers are priced at -160. The over/under has been set at 9. The pitchers taking the mound are Martin Perez and Tarik Skubal.

Chicago has a slugging % of .376 and have struck out 1,165 times, while being walked on 439 occasions. They have accumulated 539 runs batted in and 1,091 base knocks so far this season, and their team batting average is at .234. The White Sox have earned 212 doubles as a unit and have hit 143 balls out of the stadium. They have racked up 558 runs scored while holding a team OBP of .303. As a team, the Chicago White Sox are recording 4.0 runs per contest, which has them at 26th in the league.

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The White Sox have compiled a team ERA of 4.20 for the year (19th in MLB), and the staff has struck out 1,081 hitters. White Sox pitchers have allowed 155 home runs in addition to 639 runs in total (20th in baseball). Their pitching staff has walked 519 opposing batters and their FIP comes in at 4.46 as a team on the campaign. Chicago has surrendered 1,157 hits (8.5 per 9 innings) and 572 earned runs. Their K/BB ratio is 2.08 and the pitching staff holds a collective WHIP of 1.37.

The White Sox bullpen have recorded a save percentage of 48.8% and have come into the game in 97 save situations. The relievers have inherited 200 base runners for the year and 32.5% of them earned a run for their team. White Sox pitchers have stepped onto the hill with runners on base 137 times as well as having 126 appearances in high leverage situations. The White Sox have sent 449 relief pitchers to the hill this year. The relievers have tallied 56 holds this season (28th in MLB). They have compiled 20 saves for the year and have not converted 21 out of their 41 chances to save the game.

The White Sox have turned 69.6% of balls hit into play into outs out of their 11,028 innings, which ranks them 18th in baseball. The Chicago Cubs have notched a total of 3,676 putouts over the course of the season, in addition to 1,121 assists and 91 errors. Their fielding rate is holding steady at .981 which is 28th in MLB, and have earned 112 double plays.

Perez has taken the mound for 1,616 frames and has tallied 1,148 punch outs during his pro baseball career. Perez (91-90 win-loss record in his career) sits with a FIP of 4.32 while facing 7,007 batters in the major leagues. His earned run average is 4.39 (788 earned runs allowed) and he has a WHIP of 1.435. He has allowed 1,736 base knocks (9.7 hits per nine innings) and has 583 walks.

Detroit is sitting with 177 home runs over the course of the season to go along with 653 runs batted in. They have 216 two-baggers, while taking a walk 440 times as well as putting up 680 runs. The Detroit Tigers have recorded an OBP of .320 as well as a team batting average of .251 so far this season. The Tigers have a team SLG% of .422 and they have an average of 4.82 runs per contest (8th in MLB). They have struck out on 1,242 instances (5th in baseball) and have a total of 1,191 base hits.

The Tigers hold a team WHIP of 1.237 with a FIP of 4.02 as a squad so far this year. They come in at 11th in MLB as a pitching staff in total hits surrendered with 1,132. The Detroit pitching staff have allowed 595 runs over the course of the season while having a team ERA of 3.89 (540 earned runs yielded). They have earned a K/BB ratio of 8.60 (1,190 strikeouts vs 414 walks). They have allowed 160 home runs and they give up 4.28 runs per 9 innings (12th in MLB).

Detroit relievers hold an inherited score rate of 27.1% out of their 210 inherited runners. Their relievers have stepped onto the hill 120 times in high leverage situations in addition to 152 occasions with runners on. With 123 save situations, the Tigers have 65 holds in addition to 18 blown saves. They rank 7th in MLB with a save rate of 66.7%, and they have sent 433 relief pitchers onto the field for the season. Detroit has called on relievers to step onto the hill in 54 save chances and they have earned 36 saves.

The Detroit Tigers have turned 114 double plays and have accounted for a fielding rate of .986 (18th in pro baseball). The Tigers have recorded 1,211 assists, 73 errors and have accumulated 3,752 putouts for the season. In 11,256 innings on the diamond, the Tigers have a defensive efficiency of 70.2% (11th in the majors).

During his MLB career, Skubal has allowed 597 hits while he has earned 864 strikeouts in 744 frames. He has surrendered 256 earned runs while holding a WHIP of 1.025 and a FIP of 3.0. He has a strikeout to walk ratio of 5.20 and he has faced 2,967 hitters so far in his pro baseball career. Skubal (53-35 career win-loss mark) is the owner of a 3.10 earned run average and has allowed 7.2 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Detroit (-160)

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